Life Sciences Institute

The translational research and development activities at the LSI are having a large impact on Human Health and Wellness. Researchers at the LSI have been responsible for bringing targeted new drugs to the market and into clinical trials. Teams are also focused on impacting healthcare by changing the way it is practiced through the implementation of molecular based technologies to better predict health and disease.


Affiliated UBC Faculty & Postdocs

Name Role Research Interests
Abraham, Ninan Faculty (G+PS eligible/member) Mammals, pathogens, genetic analysis, proper cell funtion, development, maintenance and proper functioning of T- and B-cells
Accili, Eric Faculty (G+PS eligible/member) molecular mechanisms responsible for cellular pacemaking behavior
Allan, Douglas Faculty (G+PS eligible/member) Nervous system
Auld, Vanessa Faculty (G+PS eligible/member) Cell, Neurogenesis and Gliogenesis, Developmental Genetics, Molecular Genetics, Development, nervous system, permeability barriers, glia, Cell Biology, Genetics, in vivo imaging, epithelia
Av-Gay, Yossef Faculty (G+PS eligible/member) Infectious Diseases, Microbiology, drug discovery, Macrophage biology, Tuberculosis
Bamji, Shernaz Faculty (G+PS eligible/member) synapse biology, primary neuronal cultures, transgenic mouse models, neurodevelopmental disease
Bromme, Dieter Faculty (G+PS eligible/member) Lysosomal proteases, centre for blood research
Brooks, Donald Faculty (G+PS eligible/member) microgravity research (space station, etc); diagnostic testing device; Centre for Blood Research; biomaterials, Organic chem, blood research
Brown, Carolyn Janet Faculty (G+PS eligible/member) Gene Regulation and Expression, Chromosomes: Structure / Organization, Applied Genetics, Epigenetic control of gene expression, X-chromosome inactivation, Long non-coding RNAs, XIST RNA, Genes escaping X-chromosome inactivation, DNA methylation
Cembrowski, Mark Steven Faculty (G+PS eligible/member) Mechanisms of memory in the brain, Anxiety, Big Data, Bioinformatics, Cell types, Computation, CRISPR-Cas9, Fear, Genetics, modeling, Neural circuits, neuroscience, Neuroscience of memory, PTSD, RNAseq
Clee, Susanne Michelle Faculty (G+PS eligible/member) Obesity and diabetes are world-wide epidemics
Conway, Edward Faculty (G+PS eligible/member) Translational research, blood, hemostasis-thrombosis, transfusion, coagulation, hematology, transgenic mice, vascular biology, endothelial, immunity, bleeding, thrombosis, arthritis, Coagulation, innate immunity, endothelial medicine, inflammation, cardiovascular disease
Crowe, Sean Faculty (G+PS eligible/member) Geobiology, biogeochemistry, microbial evolution
Cullis, Pieter Faculty (G+PS eligible/member) Molecular biology for therapeutic purposes, lipids, immunological drugs
Devine, Dana Virginia Faculty (G+PS eligible/member) Biochemistry, blood regulation, platelet biology
Duong, Franck Faculty (G+PS eligible/member) Membrane protein, nanodiscs, ligand-receptor interactions, cell membranes, lipids, soluble proteins, porin, iron intake
Eltis, Lindsay Faculty (G+PS eligible/member) Microbiology, Enzymes and Proteins, Metabolism (Living Organisms), Bacterial catabolism of steroids and lignin, Mycobacterium tuberculosis, biocatalyst development
Fedida, David Faculty (G+PS eligible/member) How the heart generates, maintains and regulates electrical activity, Anesthesiology
Fernandez, Rachel Faculty (G+PS eligible/member) Bordetella pertusis, whooping cough, lipopolysaccharide
Francia, Valentina Postdoctoral Fellow Development of Drug Delivery Systems, Nucleic Acids, Pharmacokinetics, molecular biology, drug delivery, Biological Mechanisms
Gaynor, Erin Faculty (G+PS eligible/member) Molecular mechanisms of pathogenesis, foodborne human pathogen, Campylobacter jejuni
Gold, Michael Faculty (G+PS eligible/member) understanding cell signaling, morphology, trafficking, and effector function of immune cells and tumour cells
Gordon, Michael Faculty (G+PS eligible/member) Neuronal Systems, neuroscience, Neural circuits, Sensory systems, Feeding, Taste, Gustation, Drosophila, Chemosensation
Hallam, Steven Faculty (G+PS eligible/member) methanogenesis, methane oxidation, methyl coenzyme M reductase, metagenomics, environmental microbiology, genomics, proteomics, microbial ecology, systems biology, archaea, energy, bioinformatics, Microbial communities, construction and interpretation of environmental genomic libraries, generation of computational tools and workflows for taxonomic and functional binning, population genome assembly, and comparative community analysis, development and functional screens to interrogate environmental genomic libraries for bioactive small molecules and biocatalysis
Harder, Kenneth Faculty (G+PS eligible/member) Host-pathogen, tumours, infection, immunity, atherosclerosis, role of macrophages in inflammation
Horwitz, Marc Faculty (G+PS eligible/member) Mechanisms of viral-induced immune disease in a variety of complex chronic disorders
Howe, LeAnn Faculty (G+PS eligible/member) Gene regulation, Epigenetics, chromatin
Jan, Eric Faculty (G+PS eligible/member) Virus, Nucleic Acids, Proteomics, Virology, Antiviral innate immunity, translation, Protein synthesis, RNA, RNA structure function, tRNA, ribosome, RNA virus, protease, molecular biology, picornavirus, Innate immunity, coronavirus, enterovirus, SARS, coxsackievirus, virus host interactions
Jean, Francois Faculty (G+PS eligible/member) Viral Infections, Virus, Virus (Living Organisms), Antivirals, Cell Therapy of Infectious and Immune Diseases, Bioactive Molecules, Infectious Diseases, Molecular virology, Host-virus interactions, Cellular proprotein convertases, Emerging human viruses, Mosquito-borne viruses, Dengue virus, Zika virus, West Nile virus, Influenza A virus, Antiviral agents, Natural products as antiviral agents, Broad-based antiviral therapeutics, Lipid-modulating drugs, Human microRNAs, Therapeutic microRNA, Viral and cellular biomarkers, Molecular diagnostics for detecting viral infection, Circulating exosomes, Exosomal microRNAs
Johnson, Pauline Faculty (G+PS eligible/member) Diseases of the Immune System, Immunology, Inflammation, Immune-cancer interactions, Innate immunity, Macrophages and myeloid cells
Johnson, James Faculty (G+PS eligible/member) diabetes, hormones, cell biology, signal transduction, apoptosis or programmed cell death, heart failure, heart disease, calcium signalling, pancreatic cancer, obesity, longevity, imaging, Causes of type 1 and type 2 diabetes at a molecular level discovery of genes and associated gene networks linked to diabetes risk and by known risk factors that predispose individuals to diabetes
Kieffer, Tim Faculty (G+PS eligible/member) Diabetes
Kim, Hugh Faculty (G+PS eligible/member) platelet biochemistry
Kizhakkedathu, Jayachandran Faculty (G+PS eligible/member) Polymers, Biomaterials, Blood Coagulation, Macromolecular Therapeutics, Iron Chelators, Thrombosis, Cell-surface Engineering, Proteomics Tools, Implants and Medical Devices
Kopp, Janel Faculty (G+PS eligible/member) Pancreas, Pancreatic cancer, Pancreatic development, Modeling cancer
Lefebvre, Louis Faculty (G+PS eligible/member) Developmental Genetics, Gene Regulation and Expression, Genomics, Molecular Genetics, Transgenic Model, Embryonic Development, mouse developmental genetics, developmental epigenetics, genomic imprinting, placental biology, germ cell biology
Loewen, Christopher Faculty (G+PS eligible/member) Membranes and Organelles, Lipid Signalling, Lipid Traffic, Membrane Contact Sites, Genetic Networks, Systems Biology, Super Resolution Microscopy, Cell polarity, Endoplasmic Reticulum, Golgi, Membrane Diffusion Barriers, Cell Biology, Autism, Amyotrophic Lateral Sclerosis (ALS), Cancer Cell Metabolism
Lorincz, Matthew Faculty (G+PS eligible/member) Developmental Genetics, Genomics, Epigenetics, chromatin, Development, Epigenomics, Gene regulation
Matsuuchi, Linda Faculty (G+PS eligible/member) Cell signaling of specific membrane receptors, combining aspects of Cell Biology, Immunology , Biochemistry and Molecular Biology
McIntosh, Lawrence Faculty (G+PS eligible/member) Protein structure-dynamics-function, Regulation of gene expression, Signal transduction, Cancer, Enzyme mechanisms
Mizumoto, Kota Faculty (G+PS eligible/member) Cell and Developmental Biology
Mohn, William Faculty (G+PS eligible/member) pollutant biodegradation, pollutant bioremediation, biological treatment of forest industry effluents and wastes, microbial ecology, environmental biotechnology, forest soil microbial ecology, tuberculosis, microbial genomics, Microbial ecology
Molday, Robert Faculty (G+PS eligible/member) Proteins, cell structure, lipids, drug discovery, gene therapy
Moore, Edwin D Faculty (G+PS eligible/member) Cardiovascular
Moukhles, Hakima Faculty (G+PS eligible/member) Muscle cells
Murphy, Michael Faculty (G+PS eligible/member) Microbiology, Functional and Structural Proteomics, Biological and Biochemical Mechanisms, Microbial metal metabolism, Bacterial pathogenesis, Alternatives to antibiotics
Nabi, Ivan Robert Faculty (G+PS eligible/member) Intracellular signaling during neurite outgrowth and sprouting, Identification of small molecules that stimulate neurite outgrowth and regeneration, Examination of the role of semaphorins during embryonic development
O'Connor, Timothy Faculty (G+PS eligible/member) Identification of small molecules that stimulate neurite outgrowth and regeneration Examination of the role of semaphorins during embryonic development
Osborne, Lisa Faculty (G+PS eligible/member) influence that the bacteria that live on and in our intestines, lungs and skin have on human health; understanding how the host recognizes the diverse species that reside in the gut - from microscopic viruses to large, multicellular helminthic worms - and tailors an immune response of the appropriate scope and magnitude necessary to achieve homeostasis
Overall, Christopher Mark Faculty (G+PS eligible/member) Blood research, antiviral immunity