Sanne Janssen
Postdoctoral Fellow
The interplay between epigenetic marks during early mouse development, specifically focussing on epigenetic reprogramming in the early embryo in the context of developmental disorders and syndromes.
Supervisor
Research Classification
Research Interests
Epigenomics
Research Methodology
ChIP-seq
RNA-seq
WGBS
CRISPR
KO mouse
Basic molecular biology techniques: cloning, (q)PCR, WB, IF, DNA/RNA extraction, cell culture (cancer cells and mESCs)
Research Centres, Clusters, Institutes
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Publications
- Interplay between chromatin marks in development and disease (2022)
Nature Reviews Genetics, - Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing (2021)
Nature Communications, - BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells (2020)
Cell Death Discovery, 6 (1) - BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cell lines (2019)
- Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice (2014)
Developmental Biology, - Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome (2013)
Human Molecular Genetics,
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