Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Cutting and Puncture Mechanics of Soft Materials; Biological Membranes; Cytoskeletal Mechanics; Adhesion
Experience in Finite Element Analysis and Solid Mechanics
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ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
These videos contain some general advice from faculty across UBC on finding and reaching out to a potential thesis supervisor.
Graduate Student Supervision
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Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
This thesis explores bioadhesion at two scales. In many animals, adhesion plays a critical role to enable their traversal on inclined and inverted surfaces of varying chemistry. This is achieved through arrays of fibrils or micropillars found at the tips of these animals’ appendages. Synthetic mimics inspired by the design of these natural systems are actively developed, studied, and used in applications not limited to adhesion. A common limitation in these mimics is that adjacent micropillars tend to adhere to each other (self-adhere) by lateral van der Waals interactions, impeding on their intended function. Through mathematical modeling, our work demonstrates that slanting micropillars from their vertical arrangement permits them to be longer or more densely packed while avoiding self-adhesion. We derive a criterion to determine the critical angle above which slanting remains beneficial, providing developers of micropillar array devices with a tool to aid in their design. Our analysis further finds that the design of natural micropillar arrays in the ladybird beetle are close to optimal for packing or length, providing justification for the observed natural design. In cell biology, adhesion gives structure to organisms, enabling growth and proliferation. Furthermore, adhesion enables cells to contract against their surroundings, which has been identified as a key factor in cancer progression and metastasis. We developed an experimental platform to alter cellular concentrations of adenosine triphosphate (ATP) – the energetic currency of cells – and measure changes in their contractile response. Our work contributes to existing literature exploring nutritional approaches to cancer therapeutics but also quantifies general metabolic adaptation due to changes in nutrient levels. By processing cell images, we find that glucose deprived cells become less contractile than control cells. Through mathematical modeling, we additionally found that the glucose deprived are 36% less efficient during contraction (they perform 36% less work per ATP consumed). However, by interpolating between the response parameters of glucose deprived and control cells, we postulate that subject to low levels of glucose deprivation, cells maintain and even enhance their contractility and efficiency. Only beyond a critical level of glucose deprivation do both begin to diminish.
Two projects are included in the thesis. The two projects study different aspects of fracture and damage as the geometry changes. For Project 1, topology optimization is applied to optimize the fracture toughness of fibrillar adhesives towards initiated cracks. Project 1 applies to applications where the crack initiation is unavoidable and the crack initiation location is fixed. Multiple materials are considered. The objective is to minimize a weighted sum of the compliance and the J-integral, which ensures the load carrying ability and reduces the energy release rate at the crack tip. Three cases are analyzed in plane strain: double edge cracks in tension, single center crack in tension, and single edge crack in shear. With more weight put on reducing the J-integral, the load carrying structure is moved away from the crack. Highly similar results can be obtained for short cracks of different lengths. The methods are verified by: a benchmark topology optimization problem, benchmark J-integral computation problems, and the domain independence of the J-integral in topology optimization. For Project 2, deep indentation of hyperelastic materials in axisymmetry is simulated, which is important for predicting fracture. Frictionless contact and no-slip contact are considered. Four types of indenters are used. Effects of friction, indenter geometries and material constants on the potential crack shapes are studied. Among various types of finite elements, the 3-node triangular elements are chosen by analyzing the order of the numerical integration. The accuracy and the stability of the simulation are increased by modifying the traditional displacement conditions of contact to recover existing penetration. Using remeshing, the indentation can be extended to depth uncapable by commercial finite element software. The large deformation formulation is verified by comparing with the solution of Euler-Bernoulli beams in large bending. The hyperelastic formulation is verified by checking the energy conservation, as well as the agreement with linear elasticity when undeformed.
Fibrillar dry adhesives are state-of-the-art solutions for controllable and reversible attachments, inspired by nature from animals like the gecko. They depend on short-ranged intermolecular bonds, necessitating discrete attachment terminals with low elastic modulus in order to conform to the adhered material's surface roughness. At the same time, high stiffness grants resistance against interfacial crack growth and detachment under external loading. Nature provides us with a solution to this contentious requirement in the form of bi-material composite adhesives consisting of a soft tip confined by a much stiffer backing, significantly improving the adhesive performance. However, different detachment mechanisms introduced by this design and the adhesive strength corresponding to them have not been thoroughly investigated. We study the adhesive strength of an axisymmetric bi-material with a soft tip adhered to a rigid substrate subjected to normal loading, using linear elastic fracture mechanics. Two major detachment mechanisms are noticed: Crack propagation from the perimeter of the interface and from its center. Geometry and incompressibility of the adhesive layer determine the predominant detachment mode. For a geometrically confined tip under certain conditions, the maximum adhesive strength becomes independent of the crack size due to center crack stable propagation. This maximum adhesive strength is ultimately presented in the form of a power-law equation evidencing an increase in adhesive strength for thinner tips. Finally, we found a good agreement between our results and experiments.
- A New Characterization Procedure for Quasi-Linear Viscoelastic Materials Using Indentation Test: Validation with Finite Element and Experimental Results (2022)
Experimental Mechanics, 62 (6), 893-908
- A self-adhesion criterion for slanted micropillars (2022)
Extreme Mechanics Letters, 52
- Engineered nasal dry powder for the encapsulation of bioactive compounds (2022)
Drug Discovery Today, 27 (8), 2300-2308
- How friction and adhesion affect the mechanics of deep penetration in soft solids (2022)
Soft Matter, 18 (36), 6882-6887
- Mechanics of diffusion-mediated budding and implications for virus replication and infection (2022)
Journal of the Royal Society Interface, 19 (196)
- Space applications for gecko-inspired adhesives (2022)
Biomimicry for Aerospace: Technologies and Applications, 423-458
- The morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis (2022)
- Optimal Load Sharing in Bioinspired Fibrillar Adhesives: Asymptotic Solution (2021)
Journal of Applied Mechanics, Transactions ASME, 88 (3)
- Piercing soft solids: A mechanical theory for needle insertion (2021)
Journal of the Mechanics and Physics of Solids, 154
- Quasi-linear viscoelastic characterization of soft tissue-mimicking materials (2021)
Journal of Biomechanical Engineering, 143 (6)
- The role of interfacial curvature in controlling the detachment strength of bioinspired fibrillar adhesives (2021)
Mechanics of Materials, 160
- Theoretical limits in detachment strength for axisymmetric bi-material adhesives (2021)
Journal of Applied Mechanics, Transactions ASME, 88 (12)
- A study of energy dissipating mechanisms in orthogonal cutting of UD-CFRP composites (2019)
Composite Structures, 220, 460-472
- Contraction of polymer gels created by the activity of molecular motors (2019)
Soft Matter, 15 (22), 4467-4475
- Benefit of Backing-Layer Compliance in Fibrillar Adhesive Patches—Resistance to Peel Propagation in the Presence of Interfacial Misalignment (2018)
Advanced Materials Interfaces, 5 (15)
- Role of boundary conditions in determining cell alignment in response to stretch (2018)
Proceedings of the National Academy of Sciences of the United States of America, 115 (5), 986-991
- A Model for the Mullins Effect in Multinetwork Elastomers (2017)
Journal of Applied Mechanics, Transactions ASME, 84 (12)
- A swell toughening strategy for elastomers having surface cracks (2017)
Extreme Mechanics Letters, 10, 32-40
- A viscoelastic constitutive law for hydrogels (2017)
Meccanica, 52 (14), 3345-3355
- Latent heat saturation in microstructural evolution by severe plastic deformation (2016)
International Journal of Plasticity, 83, 74-89
- Load sharing in bioinspired fibrillar adhesives with backing layer interactions and interfacial misalignment (2016)
Journal of the Mechanics and Physics of Solids, 96, 428-444
- Continuous dynamic recrystallization during severe plastic deformation (2015)
Mechanics of Materials, 90, 148-156
- Anisotropic effective higher-order response of heterogeneous Cauchy elastic materials (2013)
Mechanics Research Communications, 54, 63-71
- Band-gap properties of prestressed structures (2013)
Springer Series in Materials Science, 166, 61-82
- Mindlin second-gradient elastic properties from dilute two-phase Cauchy-elastic composites Part II: Higher-order constitutive properties and application cases (2013)
International Journal of Solids and Structures, 50 (24), 4020-4029
- Mindlin second-gradient elastic properties from dilute two-phase Cauchy-elastic composites. Part I: Closed form expression for the effective higher-order constitutive tensor (2013)
International Journal of Solids and Structures, 50 (24), 4010-4019
- Controlling bandgap in electroactive polymer-based structures (2011)
IEEE/ASME Transactions on Mechatronics, 16 (1), 102-107
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