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Graduate Student Supervision
Doctoral Student Supervision (2008-2018)
Cardiac malformations affect approximately 1% of human newborns and a large number of these are due to defects in the heart valves and septum. It has been suggested that cardiac valve diseases, which make up about one third of all cardiovascular defects, arise from underlying developmental malformations that occur during embryogenesis. Interestingly, the development of the heart valves (cardiac cushions) and tissues that form cartilage templates (such as the limb) share a number of key TFs, such as TWIST1, SOX9, and NFATC1 suggesting that they have similar transcriptional programs. It has been proposed that regulatory networks involved in cartilage formation, are also active during valve development and disease. The transcription factor SOX9 has an essential role in heart valve and cartilage formation and its loss leads to major congenital abnormalities in the embryo. Regardless of this critical role, little is known about how SOX9 regulates heart valve development or its transcriptional targets. Therefore, to identify transcriptional targets of SOX9 and elucidate the role of SOX9 in the developing valves, we have used ChIP-Seq on the E12.5 atrioventricular canal (heart valves) and limb buds. Comparisons of SOX9DNA-binding regions among tissues revealed both context-dependent and context–independent SOX9 interacting regions. Context-independent SOX9 binding suggests that SOX9 may play a role in regulating proliferation-associated genes across many tissues. Generation of two endothelial specific Sox9 mutants uncovers two potential roles for SOX9 in heart valve formation: first in the initial formation of valve mesenchyme and later in the survival and differentiation of valve mesenchyme. Analysis of tissue-specific SOX9-DNA binding regions with gene expression profiles from Sox9 mutant heart valves indicates that SOX9 directly regulates a collection of transcription factors known to be important for heart development. Taken together, this study identified that SOX9 controls transcriptional hierarchies involved in proliferation across tissues and heart valve differentiation. SOX9 transcriptional targets identified in this data could be used as predictive factors of heart valve disease, or as targets for new therapeutic strategies for disease and congenital defects.
No abstract available.
Malformations of the cardiovascular system are the most common type of birth defect in humans, affecting predominantly the formation of valves and septa. While many studies have addressed the role of specific genes during valve and septa formation, a global understanding is still largely incomplete. To address this deficit we have undertaken a genome-wide transcriptional profiling of the developing heart in the mouse. We generated and analyzed 19 Serial Analysis of Gene Expression (SAGE) libraries representing different regions of the mouse heart at multiple stages of embryonic development.We speculated that genes important for heart valve development would be differentially expressed in the valve forming regions, and have dynamic temporal expression patterns. We used our dataset to identify a novel list of valve enriched genes. Using k-means cluster analysis we also uncovered 14 distinct temporal gene expression patterns in the developing valves. Unique temporal expression patterns were found to be enriched for specific signalling pathway members and functional categories such as signal transduction, transcription factor activity, proliferation and apoptosis. The most highly expressed transcription factor within the developing valves was found to be Twist1. Analysis of gene expression changes in the Twist1 null developing valves revealed a novel phenotype consistent with a role of TWIST1 in controlling differentiation of mesenchymal cells following their transformation from endothelium in the mouse. Our data suggests that TWIST1 directly activates valve specific and cell motility gene expression in the atrio-ventricular canal, while suppressing expression of valve maturation markers. This work provides the first comprehensive temporal and spatial gene expression dataset for heart development during formation of the heart valves. It is a valuable resource for the elucidation of the molecular mechanisms underlying heart development.
No abstract available.
Master's Student Supervision (2010-2017)
Development and maintenance of the hepatic phenotype is a tightly controlled process regulated by both master regulatory transcription factors and signaling pathways. Perturbations in these transcriptional networks are frequently seen in diseases such as liver cancer. The Hippo signaling pathway has been implicated in regulation of liver size and dysregulation of this pathway contributes to tumorigenesis. The primary mechanism of action of the Hippo pathway is to inhibit nuclear localization of the transcriptional co-regulator YAP, and thereby preventing YAP from binding to the TEAD family of transcription factors. Although it has been established that YAP plays a role in promoting cell proliferation, how it regulates its transcriptional targets in the liver have yet to be well-characterized. In this study, I show that YAP-overexpression in the adult mouse liver results in a shift from a mature hepatocyte to a hepatic progenitor-like gene expression pattern. Comparison of differentially expressed genes by RNA-seq revealed downregulation of hepatocyte metabolism genes and re-expression of hepatoblast genes, including Glypican-3 (Gpc3). Analysis of ChIP-seq data from both mouse liver and the human hepatoma cell line, HepG2, identified putative Gpc3 enhancers regulated by TEAD and HNF4a. I interrogated these regions using luciferase assays and identified important TEAD and HNF4a binding motifs necessary for transcriptional regulation. In addition, pathway analysis identified enrichment of the ERBB signaling pathway in the YAP-overexpressing liver. Examination of individual ERBB receptors identified upregulation of Her2 (Erbb2), which is normally enriched in hepatoblasts compared to hepatocytes. Analysis of HepG2 ChIP-seq data revealed a TEAD peak at the HER2 promoter. Using luciferase assays, I identified an important TEAD binding site contributing to transcriptional activity. Functionally, I found YAP to regulate EGF-induced HepG2 cell proliferation and PI3K-AKT signaling. This work explored novel mechanisms of gene regulation by YAP in the liver., I found that YAP activation results in re-expression of hepatic progenitor genes such as Gpc3 and Her2. Furthermore, I found the ERBB signaling pathway to be an important growth mediator downstream of YAP.
Apela, a novel gene identified by our laboratory, is expressed in mouse definitive endoderm, neural tube, and mouse embryonic stem cells (mESCs). In humans, APELA is expressed in embryonic stem cells, induced adult pluripotent stem cells (iPSCs) as well as adult kidney and prostate. APELA peptide signals through the G-protein coupled receptor, the APJ receptor, to regulate zebrafish definitive endoderm migration and cardiac development. Interestingly, the mRNA of Apela can mediate p53-dependent mESCs cell apoptosis. These findings suggest that Apela can functions as a peptide or as a lncRNA. Signaling pathways that are critical during embryogenesis are also important in cancer development and progression. However, thus far, whether APELA exerts any biological functions that regulate cancer progression is completely unknown. In this study, analysis of the cancer genome atlas (TCGA) RNA sequencing datasets reveals that APELA mRNA is expressed in different human cancer including in ovarian cancer. Real-time quantitative PCR analyses of clinical human ovarian cancer samples show that APELA mRNA levels are higher in ovarian clear cell carcinoma (OCCC), than other subtypes. Using a CRISPR/Cas9-mediated knockout approach, I have demonstrated that APELA knockout suppresses cell growth in the ovarian clear cell carcinoma cell line, OVISE. Decreased cell growth induced by APELA knockout can be partially attenuated by treating cells with recombinant human APELA protein. In addition, flow cytometry analyses show that APELA knockout induces G2/M phase arrest in OVISE cells. Western blot results show that the phosphorylation levels of ERK1/2, AKT, and cyclin B1 expression levels are significantly down-regulated in the APELA deficient OVISE cells. Moreover, our results indicate that in the APELA knockout cells, decreased cell growth is dependent on the expression of wildtype p53. Unexpectedly, knockout APELA does not affect cell growth in Ewing sarcoma cell line A673, which has high expression of APELA at mRNA level. Interestingly, the APJ receptor is expressed in A673 cells but not in OVISE cells, which strongly suggests that APELA can exert its function through APJ-independent pathway in OVISE cells. In summary, our study demonstrates that APLEA may be an important factor that mediates the progression of OCCC.
- Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development (2015)
Sanders, S.S. and Hou, J. and Sutton, L.M. and Garside, V.C. and Mui, K.K.N. and Singaraja, R.R. and Hayden, M.R. and Hoodless, P.A.
Developmental Biology 397 (2) 257-266
- MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation (2015)
Pon, J.R. and Wong, J. and Saberi, S. and Alder, O. and Moksa, M. and Grace Cheng, S.-W. and Morin, G.B. and Hoodless, P.A. and Hirst, M. and Marra, M.A.
Nature Communications 6
- SOX9 modulates the expression of key transcription factors required for heart valve development (2015)
Garside, V.C. and Cullum, R. and Alder, O. and Lu, D.Y. and Werff, R.V. and Bilenky, M. and Zhao, Y. and Jones, S.J.M. and Marra, M.A. and Underhill, T.M. and Hoodless, P.A.
Development (Cambridge) 142 (24) 4340-4350
- A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion (2014)
Chang, A.C.Y. and Garside, V.C. and Fournier, M. and Smrz, J. and Vrljicak, P. and Umlandt, P. and Fuller, M. and Robertson, G. and Zhao, Y. and Tam, A. and Jones, S.J.M. and Marra, M.A. and Hoodless, P.A. and Karsan, A.
Developmental Dynamics 243 (7) 894-905
- A regulatory network controls nephrocan expression and midgut patterning (2014)
Hou, J. and Wei, W. and Saund, R.S. and Xiang, P. and Cunningham, T.J. and Yi, Y. and Alder, O. and Lu, D.Y.D. and Savory, J.G.A. and Krentz, N.A.J. and Montpetit, R. and Cullum, R. and Hofs, N. and Lohnes, D. and Humphries, R.K. and Yamanaka, Y. and Duester, G. and Saijoh, Y. and Hoodless, P.A.
Development (Cambridge) 141 (19) 3772-3781
- Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components (2014)
Ye, X. and Zhang, H.M. and Qiu, Y. and Hanson, P.J. and Hemida, M.G. and Wei, W. and Hoodless, P.A. and Chu, F. and Yang, D.
PLoS Pathogens 10 (4)
- Delineating MEIS1 cis-regulatory elements active in hematopoietic cells (2014)
Xiang, P. and Wei, W. and Lo, C. and Rosten, P. and Hou, J. and Hoodless, P.A. and Bilenky, M. and Bonifer, C. and Cockerill, P.N. and Kirkpatrick, A. and Gottgens, B. and Hirst, M. and Humphries, K.R.
Leukemia 28 (2) 433-436
- Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation (2014)
Alder, O. and Cullum, R. and Lee, S. and Kan, A.C. and Wei, W. and Yi, Y. and Garside, V.C. and Bilenky, M. and Griffith, M. and Morrissy, A. and Robertson, G.A. and Thiessen, N. and Zhao, Y. and Chen, Q. and Pan, D. and Jones, S.J.M. and Marra, M.A. and Hoodless, P.A.
Cell Reports 9 (1) 261-271
- IFPA Meeting 2013 Workshop Report II: Use of 'omics' in understanding placental development, bioinformatics tools for gene expression analysis, planning and coordination of a placenta research network, placental imaging, evolutionary approaches to underst (2014)
Ackerman IV, W.E. and Adamson, L. and Carter, A.M. and Collins, S. and Cox, B. and Elliot, M.G. and Ermini, L. and Gruslin, A. and Hoodless, P.A. and Huang, J. and Kniss, D.A. and McGowen, M.R. and Post, M. and Rice, G. and Robinson, W. and Sadovsky, Y. and Salafia, C. and Salomon, C. and Sled, J.G. and Todros, T. and Wildman, D.E. and Zamudio, S. and Lash, G.E.
Placenta 35 (SUPPL)
- Barnacle: Detecting and characterizing tandem duplications and fusions in transcriptome assemblies (2013)
Swanson, L. and Robertson, G. and Mungall, K.L. and Butterfield, Y.S. and Chiu, R. and Corbett, R.D. and Docking, T.R. and Hogge, D. and Jackman, S.D. and Moore, R.A. and Mungall, A.J. and Nip, K.M. and Parker, J.D.K. and Qian, J.Q. and Raymond, A. and Sung, S. and Tam, A. and Thiessen, N. and Varhol, R. and Wang, S. and Yorukoglu, D. and Zhao, Y. and Hoodless, P.A. and Sahinalp, S.C. and Karsan, A. and Birol, I.
BMC Genomics 14 (1)
- Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development (2013)
Garside, V.C. and Chang, A.C. and Karsan, A. and Hoodless, P.A.
Cellular and Molecular Life Sciences 70 (16) 2899-2917
- Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling (2013)
Wei, W. and Hou, J. and Alder, O. and Ye, X. and Lee, S. and Cullum, R. and Chu, A. and Zhao, Y. and Warner, S.M. and Knight, D.A. and Yang, D. and Jones, S.J.M. and Marra, M.A. and Hoodless, P.A.
Hepatology 57 (6) 2491-2501
- Identification and analysis of murine pancreatic islet enhancers (2013)
Tennant, B.R. and Robertson, A.G. and Kramer, M. and Li, L. and Zhang, X. and Beach, M. and Thiessen, N. and Chiu, R. and Mungall, K. and Whiting, C.J. and Sabatini, P.V. and Kim, A. and Gottardo, R. and Marra, M.A. and Lynn, F.C. and Jones, S.J.M. and Hoodless, P.A. and Hoffman, B.G.
Diabetologia 56 (3) 542-552
- Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease (2012)
Hitz, M.-P. and Lemieux-Perreault, L.-P. and Marshall, C. and Feroz-Zada, Y. and Davies, R. and Yang, S.W. and Lionel, A.C. and D'Amours, G. and Lemyre, E. and Cullum, R. and Bigras, J.-L. and Thibeault, M. and Chetaille, P. and Montpetit, A. and Khairy, P. and Overduin, B. and Klaassen, S. and Hoodless, P. and Nemer, M. and Stewart, A.F.R. and Boerkoel, C. and Scherer, S.W. and Richter, A. and Dube, M.-P. and Andelfinger, G.
PLoS Genetics 8 (9)
- The TG-interacting factor TGIF1 regulates stress-induced proinflammatory phenotype of endothelial cells (2012)
Hneino, M. and Blirando, K. and Buard, V. and Tarlet, G. and Benderitter, M. and Hoodless, P. and Fran?ois, A. and Milliat, F.
Journal of Biological Chemistry 287 (46) 38913-38921
- The TGF-β/smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a smad signaling pathway (2012)
Hneino, M. and Fran?ois, A. and Buard, V. and Tarlet, G. and Abderrahmani, R. and Blirando, K. and Hoodless, P.A. and Benderitter, M. and Milliat, F.
PLoS ONE 7 (5)
- The Transcription Factor Encyclopedia (2012)
Yusuf, D. and Butland, S.L. and Swanson, M.I. and Bolotin, E. and Ticoll, A. and Cheung, W.A. and Zhang, X.Y.C. and Dickman, C.T.D. and Fulton, D.L. and Lim, J.S. and Schnabl, J.M. and Ramos, O.H.P. and Vasseur-Cognet, M. and de Leeuw, C.N. and Simpson, E.M. and Ryffel, G.U. and Lam, E.W-F. and Kist, R. and Wilson, M.S.C. and Marco-Ferreres, R. and Brosens, J.J. and Beccari, L.L. and Bovolenta, P. and Benayoun, B.A. and Monteiro, L.J. and Schwenen, H.D.C. and Grontved,
- Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse (2012)
Vrljicak, P. and Cullum, R. and Xu, E. and Chang, A.C.Y. and Wederell, E.D. and Bilenky, M. and Jones, S.J.M. and Marra, M.A. and Karsan, A. and Hoodless, P.A.
PLoS ONE 7 (7)
- Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase (2011)
Chang, A. and Fu, Y. and Garside, V. and Niessen, K. and Chang, L. and Fuller, M. and Setiadi, A. and Smrz, J. and Kyle, A. and Minchinton, A. and Marra, M. and Hoodless, P. and Karsan, A.
Developmental Cell 21 (2) 288-300
- The next generation: Using new sequencing technologies to analyse gene regulation (2011)
Cullum, R. and Alder, O. and Hoodless, P.A.
Respirology 16 (2) 210-222
- De novo assembly and analysis of RNA-seq data (2010)
Robertson, G. and Schein, J. and Chiu, R. and Corbett, R. and Field, M. and Jackman, S.D. and Mungall, K. and Lee, S. and Okada, H.M. and Qian, J.Q. and Griffith, M. and Raymond, A. and Thiessen, N. and Cezard, T. and Butterfield, Y.S. and Newsome, R. and Chan, S.K. and She, R. and Varhol, R. and Kamoh, B. and Prabhu, A.-L. and Tam, A. and Zhao, Y. and Moore, R.A. and Hirst, M. and Marra, M.A. and Jones, S.J.M. and Hoodless, P.A. and Birol, I.
Nature Methods 7 (11) 909-912
- Expression of two novel transcripts in the mouse definitive endoderm (2010)
Hassan, A.S. and Hou, J. and Wei, W. and Hoodless, P.A.
Gene Expression Patterns 10 (2-3) 127-134
- Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm (2010)
McKnight, K.D. and Hou, J. and Hoodless, P.A.
Developmental Biology 337 (2) 471-481
- Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal (2010)
Vrljicak, P. and Chang, A.C.Y. and Morozova, O. and Wederell, E.D. and Niessen, K. and Marra, M.A. and Karsan, A. and Hoodless, P.A.
Physiological Genomics 40 (3) 150-157
- Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver (2010)
Hoffman, B.G. and Robertson, G. and Zavaglia, B. and Beach, M. and Cullum, R. and Lee, S. and Soukhatcheva, G. and Li, L. and Wederell, E.D. and Thiessen, N. and Bilenky, M. and Cezard, T. and Tam, A. and Kamoh, B. and Birol, I. and Dai, D. and Zhao, Y. and Hirst, M. and Verchere, C.B. and Helgason, C.D. and Marra, M.A. and Jones, S.J.M. and Hoodless, P.A.
Genome Research 20 (8) 1037-1051
- Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding (2008)
Robertson, A.G. and Bilenky, M. and Tam, A. and Zhao, Y. and Zeng, T. and Thiessen, N. and Cezard, T. and Fejes, A.P. and Wederell, E.D. and Cullum, R. and Euskirchen, G. and Krzywinski, M. and Birol, I. and Snyder, M. and Hoodless, P.A. and Hirst, M. and Marra, M.A. and Jones, S.J.M.
Genome Research 18 (12) 1906-1917
- Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing (2008)
Wederell, E.D. and Bilenky, M. and Cullum, R. and Thiessen, N. and Dagpinar, M. and Delaney, A. and Varhol, R. and Zhao, Y. and Zeng, T. and Bernier, B. and Ingham, M. and Hirst, M. and Robertson, G. and Marra, M.A. and Jones, S. and Hoodless, P.A.
Nucleic Acids Research 36 (14) 4549-4564
- Identification of transcripts with enriched expression in the developing and adult pancreas (2008)
Hoffman, B.G. and Zavaglia, B. and Witzsche, J. and Ruiz de Algara, T. and Beach, M. and Hoodless, P.A. and Jones, S.J.M. and Marra, M.A. and Helgason, C.D.
Genome Biology 9 (6)
- Slug is a direct Notch target required for initiation of cardiac cushion cellularization (2008)
Niessen, K. and Fu, Y. and Chang, L. and Hoodless, P.A. and McFadden, D. and Karsan, A.
Journal of Cell Biology 182 (2) 315-325
- A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007)
Hou, J. and Charters, A.M. and Lee, S.C. and Zhao, Y. and Wu, M.K. and Jones, S.J.M. and Marra, M.A. and Hoodless, P.A.
BMC Developmental Biology 7
- Dynamic expression of Thyrotropin-releasing hormone in the mouse definitive endoderm (2007)
McKnight, K.D. and Hou, J. and Hoodless, P.A.
Developmental Dynamics 236 (10) 2909-2917
- Dynamics of expression of growth differentiation factor 15 in normal and PIN development in the mouse (2007)
Noorali, S. and Kurita, T. and Woolcock, B. and De Algara, T.R. and Lo, M. and Paralkar, V. and Hoodless, P. and Vielkind, J.
Differentiation 75 (4) 325-336
- Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties (2007)
Bowie, M.B. and Kent, D.G. and Dykstra, B. and McKnight, K.D. and McCaffrey, L. and Hoodless, P.A. and Eaves, C.J.
Proceedings of the National Academy of Sciences of the United States of America 104 (14) 5878-5882
- Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines (2007)
Khattra, J. and Delaney, A.D. and Zhao, Y. and Siddiqui, A. and Asano, J. and McDonald, H. and Pandoh, P. and Dhalla, N. and Prabhu, A.-L. and Kevin, M. and Lee, S. and Ally, A. and Tam, A. and Sa, D. and Rogers, S. and Charest, D. and Stott, J. and Zuyderduyn, S. and Varhol, R. and Eaves, C. and Jones, S. and Holt, R. and Hirst, M. and Hoodless, P.A. and Marra, M.A.
Genome Research 17 (1) 108-116
- Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling (2006)
Mar, L. and Hoodless, P.A.
Molecular and Cellular Biology 26 (11) 4302-4310
- Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect (2006)
Bowie, M.B. and McKnight, K.D. and Kent, D.G. and McCaffrey, L. and Hoodless, P.A. and Eaves, C.J.
Journal of Clinical Investigation 116 (10) 2808-2816
- Hippi is essential for node cilia assembly and Sonic hedgehog signaling (2006)
Houde, C. and Dickinson, R.J. and Houtzager, V.M. and Cullum, R. and Montpetit, R. and Metzler, M. and Simpson, E.M. and Roy, S. and Hayden, M.R. and Hoodless, P.A. and Nicholson, D.W.
Developmental Biology 300 (2) 523-533
- A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells (2005)
Siddiqui, A.S. and Khattra, J. and Delaney, A.D. and Zhao, Y. and Astell, C. and Asano, J. and Babakaiff, R. and Barber, S. and Beland, J. and Bohacec, S. and Brown-John, M. and Chand, S. and Charest, D. and Charters, A.M. and Cullum, R. and Dhalla, N. and Featherstone, R. and Gerhard, D.S. and Hoffman, B. and Holt, R.A. and Hou, J. and Kuo, B.Y.-L. and Lee, L.L.C. and Lee, S. and Leung, D. and Ma, K. and Matsuo, C. and Mayo, M. and McDonald, H. and Prabhu, A.-I. an
Proceedings of the National Academy of Sciences of the United States of America 102 (51) 18485-18490
- Notch Activation Results in Phenotypic and Functional Changes Consistent with Endothelial-to-Mesenchymal Transformation (2004)
Noseda, M. and McLean, G. and Niessen, K. and Chang, L. and Pollet, I. and Montpetit, R. and Shahidi, R. and Dorovini-Zis, K. and Li, L. and Beckstead, B. and Durand, R.E. and Hoodless, P.A. and Karsan, A.
Circulation Research 94 (7) 910-917
- FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse (2001)
Hoodless, P.A. and Pye, M. and Chazaud, C. and Labbe, E. and Attisano, L. and Rossant, J. and Wrana, J.L.
Genes and Development 15 (10) 1257-1271
- Formation of the definitive endoderm in mouse is a Smad2-dependent process (2000)
Tremblay, K.D. and Hoodless, P.A. and Bikoff, E.K. and Robertson, E.J.
Development 127 (14) 3079-3090
- Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling (2000)
Sirard, C. and Sammy, K. and Mirtsos, C. and Tadich, P. and Hoodless, P.A. and Itie, A. and Maxson, R. and Wrana, J.L. and Mak, T.W.
Journal of Biological Chemistry 275 (3) 2063-2070
- Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus (1999)
Hoodless, P.A. and Tsukazaki, T. and Nishimatsu, S.-I. and Attisano, L. and Wrana, J.L. and Thomsent, G.H.
Developmental Biology 207 (2) 364-379
- Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2 (1998)
Labbe, E. and Silvestri, C. and Hoodless, P.A. and Wrana, J.L. and Attisano, L.
Molecular Cell 2 (1) 109-120
- Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo (1998)
Waldrip, W.R. and Bikoff, E.K. and Hoodless, P.A. and Wrana, J.L. and Robertson, E.J.
Cell 92 (6) 797-808
- Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 (1998)
Macias-Silva, M. and Hoodless, P.A. and Tang, S.J. and Buchwald, M. and Wrana, J.L.
Journal of Biological Chemistry 273 (40) 25628-25636
- The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development (1998)
Tang, S.J. and Hoodless, P.A. and Lu, Z. and Breitman, M.L. and McInnes, R.R. and Wrana, J.L. and Buchwald, M.
Development 125 (10) 1877-1887
- Inhibitory control of neural differentiation in mammalian cells (1997)
Hoodless, P.A. and Hemmati-Brivanlou, A.
Development Genes and Evolution 207 (1) 19-28
- Mechanism and function of signaling by the TGFβ superfamily (1997)
Hoodless, P.A. and Wrana, J.L.
Current Topics in Microbiology and Immunology 228 235-272
- Mothers against decapentaplegic-related protein 2 expression in avian granulosa cells is up-regulated by transforming growth factor β during ovarian follicular development (1997)
Li, M. and Li, J. and Hoodless, P.A. and Tzukazaki, T. and Wrana, J.L. and Attisano, L. and Tsang, B.K.
Endocrinology 138 (9) 3659-3665
- Phosphorylation of MADR2 by the TGF-B receptor on both serines 465 and 467 is required for association with DPC4 and TGF-B signaling (1997)
Macias-Sitva, M. and Abdollah, S. and Hoodless, P.A. and Tsukaxak, T. and Havashi, J.H. and Attisano, L. and Wrana, J.L.
FASEB Journal 11 (9)
- MADR1, a MAD-related protein that functions in BMP2 signaling pathways (1996)
Hoodless, P.A. and Haerry, T. and Abdollah, S. and Stapleton, M. and O'Connor, M.B. and Attisano, L. and Wrana, J.L.
Cell 85 (4) 489-500
- MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling (1996)
Macias-Silva, M. and Abdollah, S. and Hoodless, P.A. and Pirone, R. and Attisano, L. and Wrana, J.L.
Cell 87 (7) 1215-1224
- MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma (1996)
Eppert, K. and Scherer, S.W. and Ozcelik, H. and Pirone, R. and Hoodless, P. and Kim, H. and Tsui, L.-C. and Bapat, B. and Gallinger, S. and Andrulis, I.L. and Thomsen, G.H. and Wrana, J.L. and Attisano, L.
Cell 86 (4) 543-552
- Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst (1994)
Duncan, S.A. and Manova, K. and Chen, W.S. and Hoodless, P. and Weinstein, D.C. and Bachvarova, R.F. and Darnell Jr., J.E.
Proceedings of the National Academy of Sciences of the United States of America 91 (16) 7598-7602
- The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo (1994)
Weinstein, D.C. and Ruiz i Altaba, A. and Chen, W.S. and Hoodless, P. and Prezioso, V.R. and Jessell, T.M. and Darnell Jr., J.E.
Cell 78 (4) 575-588
- Characterization of liver-enriched proteins binding to a developmentally demethylated site flanking the avian apoVLDLII gene (1992)
Hoodless, P.A. and Ryan, A.K. and Schrader, T.J. and Deeley, R.G.
DNA and Cell Biology 11 (10) 755-765
- Developmental regulation of specific protein interactions with an enhancerlike binding site far upstream from the avian very-low-density apolipoprotein II gene (1990)
Hoodless, P.A. and Roy, R.N. and Ryan, A.K. and Hache, R.J.G. and Vasa, M.Z. and Deeley, R.G.
Molecular and Cellular Biology 10 (1) 154-164