Michael Anglesio

Assistant Professor

Research Interests

Cancer of the Reproductive System
Host-Tumour Interaction
Cancer Diagnosis and Detection
animal models of endometriosis and cancer
Cancer prevention
early detection biomarkers
endometriosis associated cancers
gene-expression and transcriptomics
ovarian cancer etiology

Relevant Degree Programs

Affiliations to Research Centres, Institutes & Clusters

Research Options

I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.

Research Methodology

molecular biology
Animal models
Next generation sequencing
laser capture microdissection
in vitro models of cancer


Postdoctoral Fellows
Any time / year round

I am currently recruiting for a post-doctoral fellow to join a dynamic and growing research team. Project area will be research into genomic and microenvironment links between chronic cancer precursors (endometriosis and/or uterine hyperplasia) and frank carcinomas that arise from these precursor lesions (endometrial carcinoma, clear cell or endometrioid ovarian carcinoma).

Prospective students and post docs with independent/external funding may send their applications along with their research interests only if this aligns to current projects in the lab, please do not send application for projects unrelated to listed laboratory projects. For clarification: my research does not involve assisted reproductive technologies, fertility, or midwifery.

International and/or visiting student will be considered only from research groups where I have an active collaboration.

Ideal post-doctoral candidate shoud have at minimum at PhD with experience in gynecological cancer research and/or uterine derived pathologies (e.g. hyperplasia, endometriosis, and similar). Knowledge in biomarker discovery and development including outcomes analysis is beneficial. Experience using bioinformatics/sequencing based tools and working knowledge of cancer immunology is a major asset.

Candidates should work well both within a team environment and independently, be able to collaborate, mentor and supervise junior trainees. Candidates that are able to bring new knowledge and application to the group are desirable. In the context of our research programs this may include microbiome research, proteomics, and epigenomics.

I support public scholarship, e.g. through the Public Scholars Initiative, and am available to supervise students and Postdocs interested in collaborating with external partners as part of their research.
I am open to hosting Visiting International Research Students (non-degree, up to 12 months).
I am interested in hiring Co-op students for research placements.
I am interested in supervising students to conduct interdisciplinary research.

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Postdoctoral Fellows

Great Supervisor Week Mentions

Each year graduate students are encouraged to give kudos to their supervisors through social media and our website as part of #GreatSupervisorWeek. Below are students who mentioned this supervisor since the initiative was started in 2017.


Thank you to one of my co-supervisors @M_Anglesio for his guidance on my research project and patience in introducing me to the genetics of endometriosis #GreatSupervisor #UBC @UBC


Graduate Student Supervision

Master's Student Supervision (2010 - 2020)
Identifying and targeting markers of de-novo and acquired MEK-inhibitor resistance in low-grade serous ovarian carcinoma (2020)

No abstract available.

Somatic cancer-driver mutations in endometriosis: implications beyond malignancy (2018)

Introduction: Endometriosis is a chronic, inflammatory gynecological disease characterized by the ectopic growth of endometrial-like tissue. Previous studies have established endometriosis as the precursor to clear cell and endometrioid ovarian carcinomas. The presence of somatic driver mutations in endometriosis is believed to represent early events in transformation, however our group has recently described the presence of such mutations in nearly one-quarter of cases of deep infiltrating endometriosis (DE) – a form of endometriosis that rarely progresses to malignancy. These mutations may play a fundamental role in the pathogenesis of endometriosis outside of the context of cancer, however it is unclear whether they occur in other forms of endometriosis or the eutopic endometrium – the likely tissue of origin for endometriosis. The purpose of my study is to: 1) analyze and compare the mutational profiles of DE and incisional (iatrogenic; IE) endometriosis and 2) characterize somatic cancer-drivers that exist in the eutopic endometrium and determine whether the presence of such mutations reflect the aging of this tissue.Methods: I macrodissected endometriosis tissue from women with IE or DE. Extracted DNA was analyzed by targeted sequencing and mutations were orthogonally validated by droplet digital PCR. PTEN and ARID1A immunohistochemistry was also performed for each specimen. Using the same protocol, I also analyzed hysterectomy and endometrial biopsy specimens obtained from cancer-free women.Results: Overall, we detected the presence of somatic alterations in 27.5% and 36.1% of IE and DE cases respectively. These events affected canonical components of RAS/MAPK or PI3K-Akt signaling pathways. Furthermore, over 50% of cancer-free women also harboured similar somatic alterations in their eutopic endometrial tissue. The presence of somatic cancer-drivers in the eutopic endometrium are likely regional and are correlated with age (p = 0.048).Conclusions: My findings are consistent with a uterine origin of endometriosis. Somatic cancer-driver alterations are commonly found in both endometriosis and the eutopic endometrium of cancer-free women and may reflect the accumulation of DNA damage over time. These somatic alterations alone are insufficient for malignant transformation and should be interpreted with caution in the early diagnosis of gynecologic malignancies given their common occurrence in cancer-free women.

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