Olga Radivojevic
Master of Science in Rehabilitation Sciences (MSc)
Research Topic
The effects of breathing route on sensory, physiological and performance outcomes during exercise
Jordan Guenette
Professor
Research Classification
Research Interests
Clinical exercise physiology
Cardiorespiratory physiology
Mechanisms and management of breathlessness and exercise intolerance
Chronic respiratory diseases
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Cardiopulmonary exercise testing
Near Infrared Spectroscopy
Respiratory muscle electromyography
Respiratory mechanics
Respiratory and limb muscle fatigue using magnetic stimulation
Dyspnea evaluation using multiple scales
Recruitment
Master's students
Doctoral students
Postdoctoral Fellows
Any time / year round
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Dissertations completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest dissertations.
Impact of air pollution on exercise responses, dyspnea, and respiratory health in adults with and without chronic obstructive pulmonary disease (2023)
Problem: Little is known about which demographic and pulmonary function characteristics are associated with exertional dyspnea and whether or not acute exposure to traffic-related air pollution (TRAP) impacts dyspnea, pulmonary function, and exercise responses in older adults with and without chronic obstructive pulmonary disease (COPD). Methods: Study 1: We investigated the association between exertional dyspnea and select outcome measures in a random population sample (n=844) of healthy controls, at-risk smokers, and COPD (Chapter 2). Study 2: We investigated the acute effects of TRAP versus filtered air on a wide range of outcomes in healthy controls (n=11) and ex-smokers with (n=9) or without (n=9) mild-to-moderate COPD. Data from study 2 was divided into three chapters. Study 3: The association between short-term increases in ambient air pollution with rescue inhaler use, sleep duration, and physical activity was tested in COPD using remote monitoring technology (RMT) (Chapter 6).Results: Study 1 demonstrated that exertional dyspnea is significantly associated with sex, forced expiratory volume in 1 second, COPD Assessment Test score, and Medical Research Council Dyspnea score, but not lung diffusion capacity for carbon monoxide in healthy individuals, at-risk smokers, and COPD (Chapter 2). Study 2 showed that TRAP did not affect routine measures of pulmonary function in any group (Chapter 3) or impulse oscillometry-derived data, except total airway resistance at 5Hz (R₅) in healthy never smokers (Chapter 4). TRAP had a deleterious effect on exercise endurance, absolute operating lung volumes, and exertional dyspnea in healthy controls but not in ex-smokers with and without COPD (Chapter 5). Lastly, in Study 3 we showed that RMT could be useful to track inhaler use, sleep, and physical activity during periods of increased ambient air pollution in COPD (Chapter 6). Conclusion: This thesis demonstrates that exertional dyspnea is associated with disease severity and burden in COPD and that TRAP negatively impacts dyspnea, exercise endurance, and select ventilatory responses in healthy older adults but not ex-smokers with and without COPD. We also demonstrated that RMT can be useful for monitoring inhaler use, sleep, and physical activity in individuals with COPD during periods of increased air pollution.
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Sex differences in voluntary activation of the diaphragm (2022)
Purpose: Three studies were performed to examine how voluntary activation of the diaphragm changes after fatiguing tasks in young, healthy males and females. The change in diaphragm voluntary activation (D-VA) was also compared to the change in contractile function, assessed by the change in transdiaphragmatic twitch pressure (P¬DI,TW).Methods: Study 1 (Chapter 2) investigated the within- and between-session reliability of D-VA using cervical magnetic stimulation (CMS) to evoke twitches. Study 2 (Chapter 3) examined changes in D-VA after high intensity, whole-body exercise between sexes. Study 3 (Chapter 4) examined changes in D-VA after inspiratory pressure threshold loading (IPTL) between sexes.Conclusions: CMS can be used to reliably assess D-VA, measured via intraclass correlation coefficients (ICC) both within- (ICC: 0.76) and between-session (ICC: 0.88). After exercise, D-VA decreased in males and females. The decrease in D-VA was greater in males compared to females (87.4±10.8 vs 95.4±4.9%basline, respectively, p=0.036). The magnitude of the decrease in D-VA was less than the decrease in PDI,TW (Males: 70.3±12.4, Females: 85.2±16.7%baseline, p=0.024). After IPTL, both males and females showed a decrease in D-VA and PDI,TW. While males showed a greater decrease in PDI,TW (73.3±12.1 vs 87.1±15.0%baseline, respectively, p=0.016) compared to females, the decrease in D-VA was similar between sexes (88.2±10.5 vs 91.4±7.6%baseline, respectively, p=0.432). After IPTL, the decrease in PDI,TW correlated with the total respiratory work performed whereas the decrease in D-VA correlated with time until task failure. The magnitude of the decrease in PDI,TW was greater than the decrease in D-VA after IPTL. Collectively, the results of this thesis suggest that there are sex differences in the change in D-VA after exercise but not IPTL. This thesis provides a foundation for future work to investigate how diaphragm fatigability can affect exercise performance in humans.
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Physiological mechanisms of dyspnoea in patients with fibrotic interstitial lung disease and the role of hyperoxia as an exercise intervention (2018)
Problem: Dyspnoea is a common and debilitating symptom in patients with fibrotic interstitial lung disease (ILD). Unfortunately, there are no therapies that consistently reduce exertional dyspnoea in this population. Hyperoxia is a potential intervention to acutely address many of the pathophysiological mechanisms thought to be associated with dyspnoea and exercise intolerance in fibrotic ILD. However, additional research is needed to clarify the role and specific physiological and perceptual effects of hyperoxia during exercise in these patients.Methods: Study 1: Twenty fibrotic ILD patients performed two symptom limited constant work-rate cycle exercise tests at 75% of peak work-rate while breathing room air or hyperoxia, in randomized order. Ventilatory responses as well as both the intensity and qualitative dimensions of dyspnoea were measured throughout exercise. Study 2: Fourteen patients with fibrotic ILD completed an incremental cycle exercise test while breathing room air and two constant work-rate cycle exercise tests while breathing room air or hyperoxia. Diaphragmatic electromyography (EMGdi), a surrogate of neural respiratory drive (NRD), was measured with an oesophageal catheter. Neuromechanical uncoupling (NMU) was calculated as the ratio between EMGdi (% max) and tidal volume (% vital capacity). Dyspnoea intensity was recorded throughout exercise. Study 3: Sixteen patients with fibrotic ILD performed incremental and constant work-rate cycle exercise tests while breathing room air until exhaustion, wherein dyspnoea quality was evaluated throughout exercise. Conclusions: Study 1 demonstrated that hyperoxia results in clinically significant improvements in exercise tolerance, dyspnoea intensity, and dyspnoea quality. Study 2 found that dyspnoea intensity was more strongly associated with estimates of NRD than NMU during normoxic incremental cycling. However, improvements in dyspnoea intensity with hyperoxia were more strongly correlated with NMU than NRD. Study 3 showed increased work/effort was the dominant descriptor of dyspnoea throughout incremental and constant work-rate cycle exercise, but there was an increase in the selection of unsatisfied inspiration once further tidal volume expansion was constrained. Collectively, these results may contribute to the development and enhancement of symptom management in patients with ILD. In the context of rehabilitation, this may translate into improvements in patient outcomes from exercise training programs.
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Master's Student Supervision
Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
Sex differences in exercise-induced arterial hypoxaemia and pulmonary oedema development following high intensity exercise in elite endurance athletes (2024)
Introduction: Elite female endurance athletes may be more susceptible to pulmonary limitations during exercise, such as exercise-induced arterial hypoxaemia (EIAH) when compared to males. Physiological mechanisms underlying EIAH in females are not fully understood, but may be related to pulmonary oedema development. This study examined pulmonary oedema and EIAH in male and female endurance athletes in a real-world environment.Methods: Twenty participants (10M vs. 10F; V̇ O₂: 68±8 vs. 52±5 ml∙kgˉ¹∙minˉ¹) performed spirometry and a maximal incremental cardiopulmonary exercise test on a treadmill (visit 1) followed by a maximal time trial on the Grouse Grind ® trail (2.9km, 800m elevation gain) in North Vancouver (visit 2). Only nineteen participants completed visit 2 (nine females) due to seasonal closures of the Grouse Grind ® trail. Pulmonary oedema was assessed 10 minutes following exercise using handheld lung ultrasound. Oxygen saturation (SpO₂), an index of EIAH, was recorded using finger pulse oximetry.Results: Average exercise duration and heart rate during the maximal time trial were 33.2±4.9min and 171±10bpm, and 39.3±3.4min and 174±8bpm for males and females respectively. The majority of participants developed EIAH at peak exercise (Mild: M:1, F:3; Moderate: M:7, F:2; Severe: M:2, F:4) with no sex differences in SpO₂ (M: 89±6% vs. F: 90±2%, respectively, p=0.30). There were no differences in post-exercise pulmonary oedema assessed using ultrasound b-line scores between males and females (0.9±1.1 vs. 1.9±2.2, respectively, p=0.60).Conclusion: Our findings suggest that a maximal time trial did not result in the development of pulmonary oedema in either male or female participants, while both sexes demonstrated similar development of EIAH at peak exercise. These findings add to our understanding of the physiological responses to exercise between sexes and highlights a need to investigate alternative mechanisms underlying previously documented sex differences in EIAH.
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Face masks during exercise : investigating sex differences in the multidimensional components of dyspnea (2023)
Introduction: Despite consistent evidence that face masks (FM) increase dyspnea (i.e., breathlessness), very few studies have examined whether dyspnea and other physiological responses to FMs during exercise differ on the basis of sex. Accordingly, the purpose of this study was to evaluate sex differences in the multidimensional components of dyspnea, exercise performance and other physiological responses when wearing a FM during a maximal incremental exercise in healthy young males and females.Methods: In a randomized cross-over design, thirty-two healthy individuals (n=16 females, 23 ± 3 years) completed two testing sessions separated by ≥48 h. Each visit included a maximal incremental cycling test where visits 1 & 2 were randomized to either FM or control condition. Dyspnea intensity and unpleasantness were assessed using the modified 0-10 category-ratio (CR) Borg scale and the Multidimensional Dyspnea Profile was administered immediately following exercise. Diaphragmatic electromyography (EMGdi), esophageal pressure swings (Peso), and transdiaphragmatic pressure swings (Pdi) were measured via a specialized catheter to estimate neural respiratory drive and respiratory muscle pressures, respectively. Heat perception was measured using the Frank Comfort scale and a skin probe was used to measure facial temperature.Results: There were no differences in exercise duration between FM and control in males (20.3±4.3 vs. 20.9±4.2 min, p=0.13) whereas there was a significant reduction in females (13.2±3.5 vs. 13.8±3.3 min, p=0.006). At peak exercise, males exhibited significantly higher ratings of dyspnea unpleasantness and Peso in the FM condition with an increase of 2.1 Borg 0-10 units (95% CI [0.6, 3.6], p=0.01) and 4.3 cmH₂O (95% CI [0.6, 8.1], p=0.001), respectively. Both sexes experienced significantly higher facial temperatures at specified submaximal work rates (all p
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Effects of face masks on the multiple dimensions and neurophysiological mechanisms of exertional dyspnea (2022)
Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, public health officials have widely adopted the use of face masks (FM) to limit the spread of infection. Despite consistent evidence that FMs increase dyspnea (i.e., breathlessness), no studies have examined the multidimensional components of dyspnea or the physiological mechanisms of dyspnea with FMs. Methods: In a randomized cross-over design, sixteen healthy individuals (n=9 females, 25±3 y) completed three testing sessions separated by ≥48 h. Each visit included a maximal incremental cycling test where visits 2 & 3 were randomized to either FM or control condition. Dyspnea intensity and unpleasantness were assessed using the 0-10 Borg scale and the Multidimensional Dyspnea Profile (MDP) was administered immediately following exercise. Crural diaphragmatic electromyography (EMGdi), esophageal pressure (Peso), and transdiaphragmatic pressure (Pdi) were measured via a specialized catheter to estimate neural respiratory drive and respiratory muscle pressures respectively. Results: Dyspnea unpleasantness was significantly greater with the FM at the highest equivalent submaximal work rate (HESWR) (2.5±2.0 vs. 1.5±1.5 Borg 0-10 units, P=0.01) and at peak exercise (7.8±2.1 vs. 5.9±3.4 Borg 0-10 units, P=0.01) with no differences in dyspnea intensity ratings throughout exercise compared to control. There were also significant increases in the sensory quality of “smothering/air hunger” (P=0.01) and the emotional response of “anxiousness” (P=0.04) in the FM condition. There were significant increases in EMGdi (P=0.001) and esophageal pressure swings (P=0.006) at the HESWR but no differences in heart rate, peripheral oxygen saturation or breathing frequency throughout exercise with FMs compared to control. Conclusions: Our findings suggest that FMs negatively impact the affective domain of dyspnea during exercise and increase neural respiratory drive and respiratory muscle effort requirements during exercise, although the impact on other cardiopulmonary responses are minimal.
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The effect of diaphragm fatigue on the multidimensional components of dyspnea and diaphragm EMG during exercise (2019)
Purpose: To determine the effect diaphragm fatigue (DF) has on the multidimensional components of dyspnea and diaphragm EMG (EMGdi) during exercise.Methods: Sixteen healthy males (age=27, V̇O2Max=45.8 ± 9.8) underwent three study visits. Visit 1 comprised of an incremental cycle exercise test to determine maximal work rate. The following two visits involved a constant work rate (CWR) exercise test at an intensity equal to their gas exchange threshold (GET) plus 60% of the delta between GET and peak. One of the two CWR exercise tests was performed following pressure threshold loading (PTL) to induce DF, while the other served as a control. PTL involved inspiring to 60% of maximum transdiaphragmatic pressure (Pdi) to overcome a weighted load in order to initiate inspiration. DF was assessed by measuring transdiaphragmatic pressure in response to cervical magnetic stimulation of the phrenic nerves. Pdi and EMGdi were both assessed by the same esophageal balloon catheter. Breathing intensity, unpleasantness and leg discomfort ratings were assessed with the modified 0-10 category ratio Borg scale. Participants were also asked to select applicable breathing sensations during and after exercise. Peak dyspnea responses were assed via the Multidimensional Dyspnea Profile (MDP). Results: Exercise performance decreased by 1.7 minutes in the pre-fatigue condition compared to control (p=0.04). There were no changes in breathing intensity and leg discomfort (p>0.05) throughout exercise. Breathing unpleasantness increased in the pre-fatigue condition by 0.2 (p=0.09), 0.6 (p=0.04), and 0.6 (p=0.04) units at all three of the dyspnea measurement points achieved by every participant during exercise. One additional time point achieved by fifteen of the sixteen participants increased by 0.9 units (p=0.03). There were no differences in EMGdi. EMGdi significantly correlated with intensity and unpleasantness ratings in both conditions (all p
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Effects of cycling cadence on respiratory and haemodynamic responses in trained cyclists (2018)
The physiological consequences of cycling cadence selection are poorly understood. Purpose: To determine the impact of cadence on cardiorespiratory and metabolic parameters; perceptual responses; power of breathing (Pb); electromyography of the diaphragm (EMGdi) and leg muscles; and microvascular leg blood flow. Methods: Eleven trained cyclists (10M:1F; age=27±6yrs; V̇O2max=60.8±3.7ml·kg-¹·min-¹) completed four 6-min constant-load cycling trials at 10% below their gas exchange threshold (63±5% peak power) while pedaling at 60rpm, 90rpm, 120rpm, and a freely chosen cadence (FCC, 94.3±6.9 rpm), in randomized order, on an electromagnetically braked cycle ergometer. Ventilatory and metabolic parameters were measured using a commercially available metabolic cart. An oesophageal electrode balloon catheter was used to assess Pb and EMGdi. Surface EMG was placed on four leg muscles predominant in cycling. Blood flow index (BFI) was determined on the same muscles of the contralateral limb using near-infrared spectroscopy and indocyanine green. Perceptual responses were measured using the modified 0-10 category ratio Borg scale. Results: With each increase in cadence there was a corresponding increase in V̇O2 (all pairwise comparisons p0.05). Conclusion: Relative blood flow appears to be closely linked with metabolic activity of the muscle, which was significantly elevated during the highest cadence condition. In combination with the substantial rise in respiratory variables and the Pb, cadence may represent the balance between peripheral and central stressors.
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The Effects of Inspiratory Muscle Training on Physiological and Sensory Responses to Exercise in Healthy Males (2016)
Inspiratory muscle training (IMT) is an efficacious intervention to reduce dyspnoea in health and disease. Growing evidence also suggests that IMT can improve whole body exercise performance. However, the physiological mechanisms for these improvements are not well understood. We sought to examine the effects of IMT on dyspnoea, respiratory muscle electromyography (EMG), and respiratory and locomotor oxygenation to examine potential mechanisms of action for any IMT-related improvements in dyspnoea and exercise performance. 25 recreationally active healthy men completed two maximal incremental cycle exercise tests separated by 5 weeks of randomly assigned pressure threshold IMT or sham control training (SC). The IMT group (n = 12) performed 30 inspiratory efforts twice daily against a 30 repetition maximum intensity. The SC (n = 13) group performed a daily bout of 60 inspiratory efforts against 10% maximal inspiratory pressure (MIP), with no weekly adjustments. EMG electrodes on the sternocleidomastoid (SCM) and scalene muscles measured changes in muscle activity, and near-infrared spectroscopy (NIRS) optodes on the SCM, parasternal intercostals, 7th intercostal space, and vastus lateralis muscle measured changes in oxygenated and deoxygenated haemoglobin during each exercise test. Dyspnoea was measured throughout exercise using the modified Borg scale. Finally, a subset of participants (IMT: n = 11; SC: n = 11) were instrumented with a multi-pair oesophageal electrode catheter containing two balloons, to measure diaphragm EMG and respiratory pressures. IMT significantly improved MIP (pre: -138±45 vs. post: -160±43, cm H₂O, p
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Publications
- Multidimensional assessment of exertional dyspnea in young healthy males and females who select unsatisfied inspiration at peak exercise (2025)
Journal of Applied Physiology, 138 (1), 73-88 - Sex differences in exercise-induced arterial hypoxemia and pulmonary edema following high-intensity exercise in highly trained endurance athletes (2025)
Physiological Reports, 13 (1) - Sex differences in the physiological and perceptual responses to face masks during exercise (2025)
Journal of Applied Physiology, 138 (4), 926-938 - The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: Protocol for a prospective, observational cohort study (2025)
BMJ Open, 15 (3) - Dysanapsis is not associated with exertional dyspnoea in healthy male and female never-smokers aged 40 years and older (2024)
Applied Physiology, Nutrition and Metabolism, 49 (2), 223-235 - Mexican Hispanics show significant improvement in lung function approximately 1 year after having severe COVID-19 (2024)
Experimental Physiology, 109 (12), 2147-2157 - Physiological Factors Associated with Unsatisfied Inspiration at Peak Exercise in Healthy Adults (2024)
Medicine and Science in Sports and Exercise, 56 (8), 1488-1494 - Sex-differences in COPD: from biological mechanisms to therapeutic considerations (2024)
Frontiers in Medicine, 11 - The effects of endurance training on muscle oxygen desaturation during incremental exercise tests: a systematic review and meta-analysis (2024)
Frontiers in Sports and Active Living, 6 - The metabolic cost of breathing for exercise ventilations: effects of age and sex (2024)
Journal of Applied Physiology, 137 (2), 329-342 - Translating the Interplay of Cognition and Physical Performance in COPD and Interstitial Lung Disease: Meeting Report and Literature Review (2024)
Chest, 166 (4), 721-732 - Comparing the reliability of muscle oxygen saturation with common performance and physiological markers across cycling exercise intensity (2023)
Frontiers in Sports and Active Living, 5 - Effects of Face Masks on the Multiple Dimensions and Neurophysiological Mechanisms of Exertional Dyspnea (2023)
Medicine and Science in Sports and Exercise, 55 (3), 450-461 - Effects of hypoxia on exercise-induced diaphragm fatigue in healthy males and females (2023)
Physiological Reports, 11 (2) - Exercise responses and mental health symptoms in COVID-19 survivors with dyspnoea (2023)
ERJ Open Research, 9 (3) - Inflammation associated with lung function abnormalities in COVID-19 survivors (2023)
BMC Pulmonary Medicine, 23 (1) - International guideline recommendations and eligibility criteria for home oxygen therapy (2023)
The Lancet Respiratory Medicine, 11 (5), 402-405 - The effect of proportional assist ventilation on the electrical activity of the human diaphragm during exercise (2023)
Experimental Physiology, 108 (2), 296-306 - The effect of severe intensity bouts on muscle oxygen saturation responses in trained cyclists (2023)
Frontiers in Sports and Active Living, 5 - The Lancet COPD Commission: broader questions remain (2023)
The Lancet, 401 (10388), 1568-1569 - Voluntary activation of the diaphragm after inspiratory pressure threshold loading (2023)
Physiological Reports, 11 (2) - Association of BMI with pulmonary function, functional capacity, symptoms, and quality of life in ILD (2022)
Respiratory Medicine, 195 - Cardiorespiratory physiology, exertional symptoms, and psychological burden in post-COVID-19 fatigue (2022)
Respiratory Physiology and Neurobiology, 302 - Characterization and determinants of sleep measured by self-report and wrist actigraphy in patients with interstitial lung disease (2022)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 6 (2), 88-96 - Comparing the Respiratory Compensation Point With Muscle Oxygen Saturation in Locomotor and Non-locomotor Muscles Using Wearable NIRS Spectroscopy During Whole-Body Exercise (2022)
Frontiers in Physiology, 13 - Costs of oxygen therapy for interstitial lung disease and chronic obstructive pulmonary disease: A retrospective study from a universal healthcare system (2022)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 6 (6), 351-358 - Effects of the Elevation Training Mask® 2.0 on dyspnea and respiratory muscle mechanics, electromyography, and fatigue during exhaustive cycling in healthy humans (2022)
Journal of Science and Medicine in Sport, 25 (2), 167-172 - Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial (2022)
Chest, 161 (3), 662-675 - Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease Results from the CanCOLD Study (2022)
American Journal of Respiratory and Critical Care Medicine, 205 (12), 1391-1402 - Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation (2022)
Orphanet Journal of Rare Diseases, 17 (1) - Phenotyping Cardiopulmonary Exercise Limitations in Chronic Obstructive Pulmonary Disease (2022)
Frontiers in Physiology, 13 - Predictors of Expiratory Flow Limitation during Exercise in Healthy Males and Females (2022)
Medicine and Science in Sports and Exercise, 54 (9), 1428-1436 - Sex Differences in Diaphragm Voluntary Activation after Exercise (2022)
Medicine and Science in Sports and Exercise, 54 (7), 1167-1175 - Using Cardiopulmonary Exercise Testing to Understand Dyspnea and Exercise Intolerance in Respiratory Disease (2022)
Chest, 161 (6), 1505-1516 - Case Studies in Physiology: Cardiopulmonary exercise testing and inspiratory muscle training in a 59-year-old, 4 years after an extrapleural pneumonectomy (2021)
Journal of Applied Physiology, 131 (6), 1701-1707 - Effects of the Turbine™ on Ventilatory and Sensory Responses to Incremental Cycling (2021)
Medicine and Science in Sports and Exercise, 53 (1), 192-199 - Face Masks and the Cardiorespiratory Response to Physical Activity in Health and Disease (2021)
Annals of the American Thoracic Society, 18 (3), 399-407 - Impact of ageing and pregnancy on the minute ventilation/ carbon dioxide production response to exercise (2021)
European Respiratory Review, 30 (161) - Incorporating remote patient monitoring in virtual pulmonary rehabilitation programs (2021)
Canadian Journal of Respiratory Therapy, 57, 83-89 - Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold in Canadian Adults 40 to 80 Years of Age (2021)
Chest, 159 (5), 1922-1933 - Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease (2021)
Respiratory Medicine, 186 - Predictors of reduced 6-minute walk distance after COVID-19: a cohort study in Mexico (2021)
Pulmonology, 27 (6), 563-565 - Pulmonary function and functional capacity in COVID-19 survivors with persistent dyspnoea (2021)
Respiratory Physiology and Neurobiology, 288 - Reliability of diaphragm voluntary activation measurements in healthy adults (2021)
Applied Physiology, Nutrition and Metabolism, 46 (3), 247-256 - Reply to Beltrami (2021)
Experimental Physiology, 106 (3), 791-792 - Ventilatory responses to constant load exercise following the inhalation of a short-acting ß2-agonist in a laboratory-controlled diesel exhaust exposure study in individuals with exercise-induced bronchoconstriction (2021)
Environment International, 146 - A multidimensional assessment of dyspnoea in healthy adults during exercise (2020)
European Journal of Applied Physiology, 120 (11), 2533-2545 - Cardiopulmonary Exercise Testing in Patients With Interstitial Lung Disease (2020)
Frontiers in Physiology, 11 - Evaluation of the Vibe Actigraph in Patients with Chronic Obstructive Pulmonary Disease: A Pilot Study (2020)
IEEE Journal of Translational Engineering in Health and Medicine, 8 - Near-infrared spectroscopy measures of sternocleidomastoid blood flow during exercise and hyperpnoea (2020)
Experimental Physiology, 105 (12), 2226-2237 - Normative Peak Cardiopulmonary Exercise Test Responses in Canadian Adults Aged ≥40 Years (2020)
Chest, 158 (6), 2532-2545 - Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis (2020)
Chest, 158 (2), 479-490 - Scalene and sternocleidomastoid activation during normoxic and hypoxic incremental inspiratory loading (2020)
Physiological Reports, 8 (14) - Self-initiated lifestyle interventions lead to potential insight into an effective, alternative, non-surgical therapy for mitochondrial disease associated multiple symmetric lipomatosis (2020)
Mitochondrion, 52, 183-189 - Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis (2020)
Respiratory Research, 21 (1) - The effect of diaphragm fatigue on the multidimensional components of dyspnoea and diaphragm electromyography during exercise in healthy males (2020)
Journal of Physiology, 598 (15), 3223-3237 - Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth (2019)
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 317 (4), R588-R596 - Ankle Joint and Rearfoot Biomechanics During Toe-In and Toe-Out Walking in People With Medial Compartment Knee Osteoarthritis (2019)
PM and R, 11 (5), 503-511 - ERS statement on respiratory muscle testing at rest and during exercise (2019)
European Respiratory Journal, 53 (6) - Exercise Pathophysiology in Interstitial Lung Disease (2019)
Clinics in Chest Medicine, 40 (2), 405-420 - Impact of Psychological Deficits and Pain on Physical Activity of Patients with Interstitial Lung Disease (2019)
Lung, 197 (4), 415-425 - Manipulation of mechanical ventilatory constraint during moderate intensity exercise does not influence dyspnoea in healthy older men and women (2019)
Journal of Physiology, 597 (5), 1383-1399 - Minimal important difference for physical activity and validity of the international physical activity questionnaire in interstitial lung disease (2019)
Annals of the American Thoracic Society, 16 (1), 107-115 - Modelling the effects of age and sex on the resistive and viscoelastic components of the work of breathing during exercise (2019)
Experimental Physiology, 104 (11), 1737-1745 - Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease (2019)
Respiratory Physiology and Neurobiology, 266, 1-8 - Reply to: Assessment of ‘neural respiratory drive’ from the parasternal intercostal muscles (2019)
Respiratory Physiology and Neurobiology, 259, 173-175 - Supplemental oxygen for the management of dyspnea in interstitial lung disease (2019)
Current Opinion in Supportive and Palliative Care, 13 (3), 174-178 - The Impact of Cycling Cadence on Respiratory and Hemodynamic Responses to Exercise (2019)
Medicine and Science in Sports and Exercise, 51 (8), 1727-1735 - Ventilatory and sensory responses to incremental exercise in adults with a fontan circulation (2019)
American Journal of Physiology - Heart and Circulatory Physiology, 316 (2), H335-H344 - A Comparison of Pain, Fatigue, Dyspnea and their Impact on Quality of Life in Pulmonary Rehabilitation Participants with Chronic Obstructive Pulmonary Disease (2018)
COPD: Journal of Chronic Obstructive Pulmonary Disease, 15 (1), 65-72 - Contralateral limb foot rotation during unilateral toe-in or toe-out walking in people with knee osteoarthritis (2018)
Gait and Posture, 62, 132-134 - Effect of diaphragm fatigue on subsequent exercise tolerance in healthy men and women (2018)
Journal of Applied Physiology, 125 (6), 1987-1996 - Effects of Age and Sex on Inspiratory Muscle Activation Patterns during Exercise (2018)
Medicine and Science in Sports and Exercise, 50 (9), 1882-1891 - Exertional hypoxemia is more severe in fibrotic interstitial lung disease than in COPD (2018)
Respirology, 23 (4), 392-398 - Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease (2018)
European Respiratory Journal, 51 (1) - Pathophysiological mechanisms of exertional breathlessness in chronic obstructive pulmonary disease and interstitial lung disease (2018)
Current Opinion in Supportive and Palliative Care, 12 (3), 237-245 - Patterns of cardiopulmonary response to exercise in copd (2018)
ERS Monograph, 2018 (9781849840965), 107-127 - Patterns of cardiopulmonary response to exercise in fibrotic ILD (2018)
ERS Monograph, 2018 (9781849840965), 128-145 - Physical activity measurement accuracy in advanced chronic lung disease (2018)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2 (1), 9-18 - Sex differences in diaphragmatic fatigue: the cardiovascular response to inspiratory resistance (2018)
Journal of Physiology, 596 (17), 4017-4032 - Sex differences in respiratory muscle activation patterns during high-intensity exercise in healthy humans (2018)
Respiratory Physiology and Neurobiology, 247, 57-60 - The effects of age and sex on mechanical ventilatory constraint and dyspnea during exercise in healthy humans (2018)
Journal of Applied Physiology, 124 (4), 1092-1106 - Toe-in and toe-out walking require different lower limb neuromuscular patterns in people with knee osteoarthritis (2018)
Journal of Biomechanics, 76, 112-118 - Comorbidities That Cause Pain and the Contributors to Pain in Individuals With Chronic Obstructive Pulmonary Disease (2017)
Archives of Physical Medicine and Rehabilitation, 98 (8), 1535-1543 - Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease (2017)
European Respiratory Journal, 49 (5) - Effects of inspiratory muscle training on respiratory muscle electromyography and dyspnea during exercise in healthy men (2017)
Journal of Applied Physiology, 122 (5), 1267-1275 - Is parasternal intercostal EMG an accurate surrogate of respiratory neural drive and biomarker of dyspnea during cycle exercise testing? (2017)
Respiratory Physiology and Neurobiology, 242, 40-44 - Respiratory Mechanical and Cardiorespiratory Consequences of Cycling with Aerobars (2017)
Medicine and Science in Sports and Exercise, 49 (12), 2578-2584 - Resting Physiological Correlates of Reduced Exercise Capacity in Smokers with Mild Airway Obstruction (2017)
COPD: Journal of Chronic Obstructive Pulmonary Disease, 14 (3), 267-275 - Supplemental oxygen and dypsnoea in interstitial lung disease: Absence of evidence is not evidence of absence (2017)
European Respiratory Review, 26 (145) - Supplemental oxygen in interstitial lung disease: An art in need of science (2017)
Annals of the American Thoracic Society, 14 (9), 1373-1377 - Association between exercise-induced change in body composition and change in cardiometabolic risk factors in postmenopausal South Asian women (2016)
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 41 (9), 931-937 - Diaphragm recruitment increases during a bout of targeted inspiratory muscle training (2016)
Medicine and Science in Sports and Exercise, 48 (6), 1179-1186 - Effect of acute hypoxia on inspiratory muscle oxygenation during incremental inspiratory loading in healthy adults (2016)
European Journal of Applied Physiology, 116 (4), 841-850 - High oxygen delivery to preserve exercise capacity in patients with idiopathic pulmonary fibrosis treated with nintedanib methodology of the HOPE-IPF study (2016)
Annals of the American Thoracic Society, 13 (9), 1640-1647 - Mechanisms of exertional dyspnoea in symptomatic smokers without COPD (2016)
European Respiratory Journal, 48 (3), 694-705 - Qualitative dimensions of exertional dyspnea in adults with cystic fibrosis (2016)
Journal of Applied Physiology, 121 (2), 449-456 - Reply to Topalovic and Janssens. Re: Quantifying the shape of the maximal expiratory flow-volume curve to address flow limitation (2016)
Respiratory Physiology and Neurobiology, 227, 68 - Respiratory muscle endurance after training in athletes and non-athletes: A systematic review and meta-analysis (2016)
Physical Therapy in Sport, 17, 76-86 - Cardiorespiratory and sensory responses to exercise in adults with mild cystic fibrosis (2015)
Journal of Applied Physiology, 119 (11), 1289-1296 - Cardiorespiratory and sensory responses to exercise in well-controlled asthmatics (2015)
Journal of Asthma, 52 (6), 576-582 - Combined effects of mild-to-moderate obesity and asthma on physiological and sensory responses to exercise (2015)
Respiratory Medicine, 109 (11), 1397-1403 - Controlled-frequency breath swimming improves swimming performance and running economy (2015)
Scandinavian Journal of Medicine and Science in Sports, 25 (1), 16-24 - Effect of age-related ventilatory inefficiency on respiratory sensation during exercise (2015)
Respiratory Physiology and Neurobiology, 205, 129-139 - Physiologic characterization of the chronic bronchitis phenotype in GOLD Grade IB COPD (2015)
Chest, 147 (5), 1235-1245 - Physiological mechanisms of dyspnea relief following ivacaftor in cystic fibrosis: A case report (2015)
Respiratory Physiology and Neurobiology, 205, 105-108 - Pulmonary gas exchange abnormalities in mild chronic obstructive pulmonary disease: Implications for dyspnea and exercise intolerance (2015)
American Journal of Respiratory and Critical Care Medicine, 191 (12), 1384-1394 - Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD (2015)
Respiratory Physiology and Neurobiology, 219, 30-35 - Sex differences in running performance: Lessons learned from the ultramarathon (2015)
Journal of Applied Physiology, 118 (10), 1326 - Sex differences in the intensity and qualitative dimensions of exertional dyspnea in physically active young adults (2015)
Journal of Applied Physiology, 119 (9), 998-1006 - The association between cardiorespiratory fitness and abdominal adiposity in postmenopausal, physically inactive South Asian women (2015)
Preventive Medicine Reports, 2, 783-787 - Aging and sex differences (2014)
Dyspnea: Mechanisms, Measurement, and Management, Third Edition, 25-37 - Differences in respiratory muscle activity during cycling and walking do not influence dyspnea perception in obese patients with COPD (2014)
Journal of Applied Physiology, 117 (11), 1292-1301 - Does exercise test modality influence dyspnoea perception in obese patients with COPD? (2014)
European Respiratory Journal, 43 (6), 1621-1630 - Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD (2014)
European Respiratory Journal, 44 (5), 1177-1187 - New insights into the pathophysiology of mild chronic obstructive pulmonary disease (2014)
Canadian Respiratory Journal, 21 (1), 25-27 - Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014)
International Journal of COPD, 9, 187-201 - Does the respiratory system limit exercise in mild chronic obstructive pulmonary disease? (2013)
American Journal of Respiratory and Critical Care Medicine, 187 (12), 1315-1323 - Effect of fluticasone/salmeterol combination on dyspnea and respiratory mechanics in mild-to-moderate COPD (2013)
Respiratory Medicine, 107 (5), 708-716 - Impact of pulmonary rehabilitation on the major dimensions of dyspnea in COPD (2013)
COPD: Journal of Chronic Obstructive Pulmonary Disease, 10 (4), 425-435 - Inspiratory capacity during exercise: Measurement, analysis, and interpretation (2013)
Pulmonary Medicine - Can an 86-year-old woman with advanced lung disease be a world class athlete? (2012)
Respiratory Physiology and Neurobiology, 181 (2), 162-166 - Components of the COPD assessment test (CAT) associated with a diagnosis of COPD in a random population sample (2012)
COPD: Journal of Chronic Obstructive Pulmonary Disease, 9 (2), 175-183 - Decline of resting inspiratory capacity in COPD: The impact on breathing pattern, dyspnea, and ventilatory capacity during exercise (2012)
Chest, 141 (3), 753-762 - Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD? (2012)
European Respiratory Journal, 40 (2), 322-329 - Effects of an aging pulmonary system on expiratory flow limitation and dyspnoea during exercise in healthy women (2012)
European Journal of Applied Physiology, 112 (6), 2195-2204 - From the authors (2012)
European Respiratory Journal, 39 (3), 792 - Limitations of respiratory muscle and vastus lateralis blood flow during continuous exercise (2012)
Respiratory Physiology and Neurobiology, 181 (3), 302-307 - New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients (2012)
Expert Review of Respiratory Medicine, 6 (6), 651-662 - Respiratory consequences of mild-to-moderate obesity: Impact on exercise performance in health and in chronic obstructive pulmonary disease (2012)
Pulmonary Medicine - Response (2012)
Chest, 141 (2), 569 - Response (2012)
Medicine and Science in Sports and Exercise, 44 (6), 1195 - The effects of normobaric hypoxia and hypobaric hypoxia on exercise-induced pulmonary edema (2012)
Journal of Applied Physiology, 112 (10), 1789 - Blood flow index using near-infrared spectroscopy and indocyanine green as a minimally invasive tool to assess respiratory muscle blood flow in humans (2011)
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 300 (4) - Determinants of expiratory flow limitation in healthy women during exercise. (2011)
Medicine and science in sports and exercise, 43 (9), 1666-1674 - Diaphragm fatigue after submaximal exercise with chest wall restriction (2011)
Medicine and Science in Sports and Exercise, 43 (3), 416-424 - Effect of adjunct fluticasone propionate on airway physiology during rest and exercise in COPD (2011)
Respiratory Medicine, 105 (12), 1836-1845 - Effects of BMI on static lung volumes in patients with airway obstruction (2011)
Chest, 140 (2), 461-468 - Is the men's marathon world record 25 years behind the women's record? (2011)
Journal of Applied Physiology, 110 (1), 285 - Mechanisms of dyspnoea relief following radiation treatment in a patient with severe COPD (2011)
European Respiratory Journal, 38 (3), 728-730 - Sex differences in exertional dyspnea in patients with mild COPD: Physiological mechanisms (2011)
Respiratory Physiology and Neurobiology, 177 (3), 218-227 - Sternocleidomastoid muscle deoxygenation in response to incremental inspiratory threshold loading measured by near infrared spectroscopy (2011)
Respiratory Physiology and Neurobiology, 178 (2), 202-209 - The role of pharmacotherapy in mild to moderate chronic obstructive pulmonary disease (2011)
Therapeutic Advances in Respiratory Disease, 5 (4), 245-254 - Effect of thoracic gas compression and bronchodilation on the assessment of expiratory flow limitation during exercise in healthy humans (2010)
Respiratory Physiology and Neurobiology, 170 (3), 279-286 - Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sickness (2010)
European Journal of Emergency Medicine, 17 (2), 119-122 - Pulmonary edema in athletes: Methodology or meaningful physiology? (2010)
Journal of Applied Physiology, 109 (4), 1277-1278 - Respiratory function and the obesity paradox (2010)
Current Opinion in Clinical Nutrition and Metabolic Care, 13 (6), 618-624 - Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes (2010)
Journal of Applied Physiology, 109 (1), 35-46 - Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers (2009)
Journal of Applied Physiology, 107 (5), 1622-1628 - Sex differences in the resistive and elastic work of breathing during exercise in endurance-trained athletes (2009)
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 297 (1) - Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue in trained cyclists (2008)
Journal of Physiology, 586 (22), 5575-5587 - Human respiratory muscle blood flow measured by near-infrared spectroscopy and indocyanine green (2008)
Journal of Applied Physiology, 104 (4), 1202-1210 - Mechanics of breathing during exercise in men and women: Sex versus body size differences? (2008)
Exercise and Sport Sciences Reviews, 36 (3), 128-134 - The contribution of intrapulmonary shunts to the alveolar-to-arterial oxygen difference during exercise is very small (2008)
Journal of Physiology, 586 (9), 2381-2391 - Exercise-induced arterial hypoxaemia in active young women (2007)
Applied Physiology, Nutrition and Metabolism, 32 (6), 1263-1273 - Influence of cadence, power output and hypoxia on the joint moment distribution during cycling (2007)
European Journal of Applied Physiology, 102 (1), 11-18 - Inspiratory muscle training attenuates the human respiratory muscle metaboreflex (2007)
Journal of Physiology, 584 (3), 1019-1028 - Intense hypoxic cycle exercise does not alter lung density in competitive male cyclists (2007)
European Journal of Applied Physiology, 99 (6), 623-631 - Lung density is not altered following intense normobaric hypoxic interval training in competitive female cyclists (2007)
Journal of Applied Physiology, 103 (3), 875-882 - Physiological consequences of a high work of breathing during heavy exercise in humans (2007)
Journal of Science and Medicine in Sport, 10 (6), 341-350 - Respiratory mechanics during exercise in endurance-trained men and women (2007)
Journal of Physiology, 581 (3), 1309-1322 - Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity (2006)
Journal of Applied Physiology, 100 (4), 1204-1209 - Measurement of exercise ventilation by a portable respiratory inductive plethysmograph (2006)
Respiratory Physiology and Neurobiology, 154 (3), 389-395 - No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai purnima festival at 4380 m (2006)
High Altitude Medicine and Biology, 7 (4), 281-289 - Variable effects of respiratory muscle training on cycle exercise performance in men and women (2006)
Applied Physiology, Nutrition and Metabolism, 31 (2), 159-166 - Acute hypoxic ventilatory response and exercise-induced arterial hypoxemia in men and women (2004)
Respiratory Physiology and Neurobiology, 143 (1), 37-48 - Sex differences in respiratory exercise physiology (2004)
Sports Medicine, 34 (9), 567-579
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St. Paul's Hospital
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