Centre for Heart Lung Innovation

The Centre for Heart Lung Innovation (HLI) housed within Providence Health Care's St. Paul's Hospital in the heart of downtown Vancouver, British Columbia, Canada. The HLI (previously the James Hogg Research Centre) is a University of British Columbia (UBC) Senate-approved centre of cardiovascular, pulmonary, and critical care expertise.

Our research activities and programs have grown rapidly since the establishment of the fledgling pulmonary laboratory in 1977 when Dr. Jim Hogg, along with Dr. Peter Paré and Lisa Baile were recruited to St. Paul's Hospital to open the Pulmonary Research Laboratory.  Expansion of the focus to include cardiovascular and critical care research occurred in the late 1980’s and early 1990’s with the recruitment of Drs. Mike Allard, Keith Walley, Jim Russell, and Bruce McManus. The growing laboratory was renamed the McDonald Research Laboratories (MRL) when the Cardiovascular Research Laboratory (1993) and the Atherosclerosis Specialty Laboratories (1995) joined the research environment.


Affiliated UBC Faculty & Postdocs

Name Role Research Interests
Allard, Michael Faculty (G+PS eligible/member) Control of energy metabolism in normal and pathologic hearts; Physiologic and Pathologic Cardiac hypertrophy; Contribution of Metabolism to myocardial dysfunction after ischemia and reperfusion, especially in the setting of cardiac hypertrophy; Cardiovascular Pathology
Bernatchez, Pascal Faculty (G+PS eligible/member) Cardiovascular Diseases; Cardiovascular System; Genetic Diseases; Hypertension; Atherosclerosis; Angiogenesis; Muscular Diseases; Neuromuscular Diseases; Lipid/Lipoprotein analysis; Lipid Disorders; Pharmacokinetics; Cell Signaling and Infectious and Immune Diseases; angiogenesis; endothelium; nitric oxide; muscular dystrophy; atherosclerosis; endothelial dysfunction; lipoproteins; Marfan syndrome; vascular disease; Inflammation
Boyd, John Faculty (G+PS eligible/member) The cross-application of techniques from cardiovascular physiology and immunology has resulted in exciting discoveries, including proving for the first time that stimulation of Toll-Like Receptors expressed by cardiac myocytes resulted in cardiac contractile dysfunction
Brunham, Liam Faculty (G+PS eligible/member) Medical, health and life sciences; Lipids; Genetics; Pharmacogenomics; Cardiovascular diseases
Camp, Patricia Faculty (G+PS eligible/member) Rehabilitation; Environment and Respiratory Diseases; Native Health; Rehabilitation Care and Services; Chronic Obstructive Pulmonary Disease; Mobility; Health Care Technologies; Telemedicine; pulmonary rehabilitation; health services delivery; chronic obstructive pulmonary disease; Indigneous health; Mixed methods; Knowledge translation; Physical Activity; E-health
Carlsten, Christopher Faculty (G+PS eligible/member) Environment and Respiratory Diseases
Choi, Ka-Yee Grace Postdoctoral Fellow Cell Signaling and Infectious and Immune Diseases; Immune Mediators: Cytokines and Chemokines; Diseases of the Immune System; Antibiotics and Resistance; Host defence peptides; Multi-drug resistant organisms; Antibiotic resistance; Immune modulation; Chronic respiratory infectious diseases; Cystic fibrosis; Air liquid interface (ALI) model
Daley, Denise Faculty (G+PS eligible/member) Complex Trait Genetics; Genetic Diseases; Asthma; Susceptibility Genes; Genetics of Aging; genetic epidemiology; statistical genetics; Epigenetics; gene-gene and gene-environment interactions
Dorscheid, Delbert Richard Faculty (G+PS eligible/member) Asthma, Inflammatory Respiratory Diseases, Respiratory System
Francis, Gordon Faculty (G+PS eligible/member) lipoproteins; Cholesterol metabolism; Cardiovascular risk factors; Prevention of cardiovascular disease and diabetes; High density lipoproteins (HDL)
Guenette, Jordan Faculty (G+PS eligible/member) Respiratory diseases; Other biological sciences; Clinical exercise physiology; Cardiorespiratory physiology; Mechanisms and management of breathlessness and exercise intolerance; Chronic respiratory diseases
Hackett, Tillie-Louise Faculty (G+PS eligible/member) Molecular determinants of COPD, small airway obstruction, angiotensin signalling, defective airway epithelial differentiation in asthma, human lung cell repository
Krahn, Andrew Faculty (G+PS eligible/member) management of cardiac arrhythmias; investigation of genetic causes of arrhythmias, causes of loss of consciousness and implantable arrhythmia device monitoring
Leipsic, Jonathon Faculty (G+PS eligible/member) Diagnostic performance and radiation reduction as well as CT to guide minimally invasive valve intervention
Luo, Honglin Faculty (G+PS eligible/member) Viral Infections; Cardiomyopathy; Lung Cancer; Central Nervous System Inflammatory Diseases; Protein quality control in cardiac remodeling; Oncolytic virus for lung cancer therapy; Enteroviral infection and neurodegeneration; RNA viruses
McNagny, Kelly Marshall Faculty (G+PS eligible/member) Cellular immunology; Regenerative medicine (including stem cells and tissue engineering); Stem Cells; Immunology; Inflammation; Mouse models of human disease; Tissue degeneration/regeneration; Cancer; innate immune response; kidney function; Biologics and therapeutics
Ng, Raymond Tak-yan Faculty (G+PS eligible/member) Data mining and analysis, health informatics, text summarization, text mining
Quon, Bradley Faculty (G+PS eligible/member) Cystic Fibrosis; Epidemiology; Respiratory System; Proteomics; Immune Mediators: Cytokines and Chemokines; biomarker discovery and development; clinical epidemiology; health care economics; medication adherence
Russell, James Faculty (G+PS eligible/member) old world, Iron Age, Celtic, classical Greek, Roman and Byzantine art, archaeology, architecture, ancient Roman daily life and culture;Roman military organization early Christianity; magic in antiquity; Greek and Roman inscriptions and coins; Scottish and Irish archaeology; old world and classical architecture, archaeology and culture with emphasis on Western Europe and Middle East; Celtic (especially Ireland and Scotland); Greek and Roman, classical and Byzantine; Latin, Greek, Lallans and lowland Scots; Scottish literature; Robert Burns; Scottish poetry generally; ancient through early Islam, especially Turkey; Eastern Europe, New therapy for sepsis (severe infection), septic shock and acute lung injury, role of genetics of the inflammatory response in the critically ill
Ryerson, Christopher Faculty (G+PS eligible/member) Interstitial lung disease, idiopathic pulmonary fibrosis, combined pulmonary fibrosis and emphysema, dyspnea, pulmonary rehabilitation, symptom management, health care databases.
Sadatsafavi, Mohsen Faculty (G+PS eligible/member) Respiratory diseases; Epidemiology (except nutritional and veterinary epidemiology); Epidemiology; Biostatistics; Respiratory Research
Sandford, Andrew Faculty (G+PS eligible/member) genetic basis of asthma and has extended his studies to include the genetics of chronic obstructive pulmonary disease (COPD) and peanut allergy as well as the genetic basis of pulmonary disease severity in cystic fibrosis; potential effects on gene function of genetic variants associated with these disease outcomes
Schellenberg, R Robert Faculty (G+PS eligible/member) asthma and allergic inflammation with primary interests in the mechanisms of excessive airway narrowing of asthmatic tissues and the modulation of chemotaxis and apoptosis (programmed cell death) of basophils and eosinophils; unique modulation of basophils versus eosinophils in terms of the chemokines inducing migration, the proteases involved in this process, and the cytokines leading to prolonged survival by inhibition of apoptosis.
Seow, Chun Yong Faculty (G+PS eligible/member) Biological and Biochemical Mechanisms; Asthma; Muscle; Respiratory System; Physiology; Airway smooth muscle; Contraction mechanism
Sin, Donald Faculty (G+PS eligible/member) CODP (Chronic Obstructive Pulmonary Disease)
Tebbutt, Scott Faculty (G+PS eligible/member) Genomics and Proteomics; Asthma; Heart Transplantation; Complex Trait Genetics; Fungal Infections; Occupational Lung Diseases; Dual organism molecular interaction (fungal spores & human airway epithelium); Early and late reactions in allergic asthma and rhinitis; Diagnostics of acute heart rejection; Neonatal vaccine immunogenicity; Systems biology, biomarkers & bioinformatics
Van Eeden, Stephanus Faculty (G+PS eligible/member) Mechanisms of lung inflammation, particularly, lung inflammation caused by infection, cigarette smoking and air pollution
Walley, Keith Faculty (G+PS eligible/member) Organ failure during sepsis
Yang, Decheng Faculty (G+PS eligible/member) Cardiovascular and pulmonary, infectious diseases, host gene responses to viral infections