Kelly Marshall McNagny

Prospective Graduate Students / Postdocs

This faculty member is currently not actively recruiting graduate students or Postdoctoral Fellows, but might consider co-supervision together with another faculty member.


Research Interests

Stem Cells
Mouse models of human disease
Tissue degeneration/regeneration
innate immune response
kidney function

Relevant Degree Programs



Dr. Kelly McNagny obtained his Ph.D. in Cellular Immunology at the U. of Alabama at Birmingham in 1990. There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. He then moved to the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany where he performed his postdoctoral studies in the lab of Dr. Thomas Graf from 1991 to 1996. There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. He continued his studies at the EMBL as a semi-independent, Visiting Scientist from 1996 to 1998 prior to starting his own laboratory at The Biomedical Research Centre, at UBC where his currently a full professor in Medical Genetics and interim co-director of The BRC.

His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. Through gene knockout studies he has shown that these molecules act as a type of molecular “Teflon” to make cells more mobile and invasive and also facilitate chemotaxis. He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression.

Dr. McNagny has received a number of awards for his work at UBC including a CIHR Scholarship, a Michael Smith Foundation for Health Research Senior Scholarship and the 2002 Showell-Pfizer Junior Faculty Award from the American Association for Immunology. He is a member of the Stem Cell Network Centre of Excellence (past member of the Stem Cell Policy Committee and Research Management Committee and current Sub-chair of the Training and Education Committee), and a member of the AllerGen Network Centre of Excellence (Research Management Committee and Co-Chair of the Biomarkers Program).

Research Methodology

mouse models of inflammation
molecular biology
mutant mice
Flow cytometry
RNA sequencing


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Doctoral students
I am open to hosting Visiting International Research Students (non-degree, up to 12 months).

Graduate Student Supervision

Doctoral Student Supervision (2008-2018)
The role of ROR alpha and CD34 in mucosal inflammation and fibrosis (2017)

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. Type 2 immunity has long been associated with fibrotic scarring because of its role in wound healing and parasite-initiated tissue remodeling. Our objective was to examine two components of this inflammatory pathway that could potentially be modulated to limit fibrosis, namely RORα, a nuclear receptor required for ILC2 development, and CD34, a sialomucin involved in trafficking of eosinophils and mast cells to peripheral tissues. Using a model of infection-induced chronic gut inflammation, we demonstrate that Rora-deficient mice are protected from fibrosis; infected intestinal tissues displayed diminished pathology and attenuated collagen deposition. Although Rora is known for its role in ILC2s, we found that Salmonella-induced fibrosis was independent of eosinophils, STAT6 signaling and Th2 cytokines arguing that ILC2s are dispensable in this disease model. Instead, we observed reduced levels of ILC3- and T cell-derived IL-17A and IL-22 in infected tissues. Furthermore, using Rorasg/sg/Rag1-/- bone marrow chimeric mice, we found that restoring ILC function was sufficient to re-establish IL-17A and IL-22 production and a profibrotic phenotype. Our findings suggest that RORα-dependent ILC3 functions are pivotal in mediating gut fibrosis and they offer an avenue for therapeutic intervention in Crohn’s-like diseases. CD34 has been shown to drive lung inflammation and colitis by coordinating immune cell recruitment. However CD34 is also expressed by multiple non-hematopoietic subsets including endothelial and mesenchymal cells. To assess CD34 function in pulmonary repair, we induced lung injury by bleomycin administration. We found that Cd34-/- mice displayed severe weight loss and early mortality compared to WT controls. CD34-deficient animals developed severe interstitial edema and endothelial delamination, indicating impaired endothelial function. Chimeric Cd34-/- mice reconstituted with WT hematopoietic cells exhibited early mortality compared to WT mice reconstituted with Cd34-/- cells thus confirming this to be a non-hematopoietic defect. Lastly, CD34-deficient mice were more sensitive to lung damage caused by influenza infection, displaying greater weight loss and more extensive pulmonary remodeling. These results suggest that CD34 plays a protective role in maintaining vascular integrity in response to lung damage.

Role of group 2 innate lymphoid cells and SHIP-1 in mucosal immunity (2015)

Mucosal surfaces present an important barrier between the host and environment. Maintenance of barrier function requires intricate cross-talk between a diverse array of immune cells and the epithelia, acting synergistically to respond to harmful antigens and maintain tolerance to innocuous antigens. In this thesis I utilized an array of transgenic animals to explore the cellular and molecular mechanisms that initiate adaptive immune responses in the lung and gut mucosa.Recently, innate lymphoid cells have been characterized for their role in maintaining barrier immunity. Group 2 innate lymphoid cells (ILC2s) colonize the lung and provide a rapid source of IL-5 and IL-13 in a T and B cell independent manner in response to protease antigens. Using ILC2-deficient mice, I examined the role of these cells in mucosal inflammation using mouse models of allergic asthma and hypersensitivity pneumonitis (HP). ILC2s were critical in initiation of a Th2 response to locally, but not systemically delivered allergens and were completely dispensable for Th1 and Th17 dependent responses. The PI3K pathway plays an important role in regulating leukocyte activation, survival, migration and cytokine release. It is negatively regulated by the lipid phosphatase Ship1, and Ship1-/- mice develop a wide array of hematological disorders leading to a reduced lifespan. The severe phenotype associated with loss of Ship1 throughout the immune systems masks subtler roles it plays in specific leukocyte subsets. Using a conditional deletion approach, I examined the role of Ship1 in T cells, B cells and dendritic cells (DCs) in mouse models of allergic asthma and helminth infection. While loss of Ship1 in B cells did not influence susceptibility to a HDM model of allergic asthma, loss of Ship1 in either the T cells or DCs protected from disease development due to an immune skewing to a Th1 response. Additionally, loss of Ship1 in DCs rendered mice susceptible to infection with the intestinal helminth Trichuris muris, further highlighting this Th1 immune skewing.

The structural and functional importance of the CD34 family in lung function and vascular cell biology (2012)

Despite the widespread use of CD34-family sialomucins (CD34, podocalyxin (Podxl) andendoglycan) as vascular endothelial cell (EC) markers, there is remarkably little known oftheir role in vascular development and functions with the exception of vessel lumenformation in the developing mouse embryo (Podxl) and vessel patency during tumorangiogenesis and inflammation (CD34). Because germ-line deletion of Podxl in mice causesperinatal death, we generated mice that conditionally delete Podxl in vascular endothelialcells (PodxlΔEC mice) to study the role of podocalyxin in adult mouse vessels. AlthoughPodxlΔEC adult mice are viable and thrive, we discovered increased basal and inflammationinducedpulmonary vascular permeability. Furthermore, PodxlΔEC mouse adult lungs displayairspace enlargement with increased collagen deposition and exhibit a gene expressionprofile similar to regenerating lung. To study whether endothelial cell morphology influencesthe defective lung architecture and the vascular permeability phenotype in PodxlΔEC mice, weisolated primary vascular ECs from lung tissue. PodxlΔEC ECs display enhanced adhesion tofibronectin (FN) in a static adhesion assay. When plated on matrix-coated transwells,PodxlΔEC EC spread normally on FN but display defective spreading on laminin and collagenI. Thus, expression of Podxl in EC is required for normal lung architecture and function inadult mice and adhesion of EC to extracellular matrix components.Although its expression has not been well characterized, in humans, endoglycan expressionhas been reported in vascularized tissues. In mouse blood vessels, we showed that vascularsmooth muscle cells (vSMC), but not EC, express the highest levels of endoglycan. Using amouse aortic smooth muscle line (MOVAS-1) we found that forced expression ofendoglycan enhances basal but not platelet derived growth factor (PDGF)ββ-dependentvSMC migration in vitro. Further studies to understand the role of endoglycan in primaryvSMC showed that endoglycan is upregulated with differentiation to a contractile phenotype,but is not influenced by inflammatory stimuli or mitogenic factors. The findings of this thesis suggest that the CD34 family regulates vascular development andfunction with a role for podocalyxin in EC-matrix adhesion relevant to normal lung functionand a role for endoglycan in SMC differentiation and migration.

The role of podocalyxin and CD34 in mouse models of anemia, asthma, ulcerative colitis and tumor growth (2010)

No abstract available.

Mast cells : homeostatic regulation, activation, gene expression, surface antigens, and role in allergic disease (2009)

Overall, we aimed to discover more about mast cell physiology, focusing on their homeostatic regulation in vivo, their activation in vitro and in allergic disease, their gene expression patterns, and their surface antigens. In our first study, our objective was to establish the function of Src homology 2-containing inositol 5’-phosphatase (SHIPI), in mast cells in vivo. SHIP1 inhibits immune receptor signaling throughhydrolysis of the phosphatidylinositol-3 kinase (P13K) product Pl-3,4,5-P₃ ,forming P1-3,4-P₂. In mast cells, SHIPI represses FcεRI- and cytokine-mediated activation in vitro, but little is known regarding the function of SHIPI in mast cells in vivo, or the susceptibility of Shipl⁻/⁻ mice to mast cell-associated diseases. We found that ⁻ mice have systemic mast cell hyperplasia, increased serum levels of IL-6, TNF, and IL-5, and a heightened anaphylactic response. Further, by reconstituting mast cell-deficient mice with Ship1⁺/⁺ or Shipl⁻/⁻ mast cells, we found that the above defects were due to loss of SHIPI in mast cells. Additionally, we found that micereconstituted with Shipl⁻/⁻ mast cells suffered worse allergic asthma pathology than those reconstituted with Ship1⁺/⁺ mast cells. In summary, our data show that SHIPI represses allergic inflammation and mast cell hyperplasia in vivo, and that SHIPI exerts these effects specifically in mast cells. In our second study we compared Lin⁻Sca-1⁺c-kit⁺ (LSK) cells, which are highlyenriched for hematopoietic stem cells (HSC), and mast cells, using microarray expression analysis, and identified prion protein (PrPC) as a potentially novel marker of mast cells. Upon further investigation, we found that PrPC (1) is expressed on the surface of human and mouse mast cells, both in vitro and in vivo; (2) is not required for mast cell differentiation or tissue homeostasis; (3) is released by mast cells atsteady state and rapidly upon activation; and (4) is released in response to mast cell dependent allergic inflammation in vivo. Since mast cells are long-lived and known to traffic to the brain and central nervous system (CNS), our observations could have important implications for the transmission and pathology of prion diseases. Further, mast cells could be a unique system to investigate PrPc’s normal function.

Role of podocalyxin in hematopoiesis and cell migration (2008)

CD34 and its relatives, Podocalyxin and Endoglycan, comprise of a family ofsurface sialomucins expressed by hematopoietic stem/progenitor cells, and vascularendothelia. Recent data suggest that they serve as either pro- or anti-adhesion moleculesdepending on their cellular context and their post-translational modifications. We wereinterested in identifying Podocalyxin ligands and their cellular distribution andunderstanding the role of these factors in signaling, adhesion and migration. Using both alambda phage screen assay and mass spectrometry, we identified the Na⁺/H⁺ exchangerregulatory factor-i (NHERF-l) as a selective ligand for Podocalyxin and Endoglycan butnot for the closely related CD34. Furthermore, we showed that NHERF-1 is expressedby all, lineage⁻, Sca-1⁺ and c-kit⁺ (LSK) cells, which are known to express Podocalyxinand have long-term repopulating characteristics of hematopoietic stem cells. In addition,upon IL-3 stimulation of a factor dependent cell line (FDC-P 1) these proteins re-localizeand co-localize in an asymmetrical pattern. By using a lentiviral based shRNA system tosilence Podocalyxin and NHERF- i proteins, we observed that migration across stromalmonolayer towards a CXCL12 and SCF gradient is significantly impeded in cells thatlack Podocalyxin but not NHERF-1. Following in vitro stimulation with a combinationof CXCL12 and SCF we observed that Podocalyxin co-associates with CXCR4.Furthermore, cells lacking Podocalyxin have decreased phospho-AKT, a key signalingmolecule downstream of c-kit and CXCR4 receptors. Taken together, our data supportsthe conclusion that Podocalyxin co-association with CXCR4 modulates downstreamsignaling to efficiently regulate HSC homing.

Master's Student Supervision (2010-2017)
The role of podocalyxin in breast cancer progression and metasasis (2014)

No abstract available.

The role of SHIP1 in modulating disease severity in the K/BxN serum transfer model of rheumatoid arthritis (2011)

SHIP1 (SH2 domain containing inositol-5ʼ-phosphatase) is a negative regulator of thephosphatidylinositol-3 kinase (PI3K) pathway. SHIP1 is expressed in hematopoietic cells,and mediates its effect by hydrolyzing PIP₃, an important second messenger generated bythe PI3K pathway. In this way, SHIP attenuates a variety of signaling cascades includingthose mediating cell survival and proliferation. Due to its importance in regulating immunecell signaling, SHIP1 is an attractive therapeutic target.In this thesis, I explored the role of SHIP1 in the context of rheumatoid arthritis, anautoimmune inflammatory disease. To this end, I employed the K/BxN serum transfer modelof rheumatoid arthritis. This disease model is auto-antibody driven and lymphocyteindependent, and thus facilitates characterization of the effector phase of disease, a processthat relies on components of the innate immune system. Arthritis was dramaticallyexacerbated in global SHIP1 knock-out mice, as evidenced by changes in ankle thickness,clinical scoring and histological analysis. Heterozygous SHIP1 mice also displayedincreased disease severity in comparison to wild type litter mates, possibly due to anexpanded population of circulating neutrophils, that increases with age. Since naive globalSHIP1 knock-out mice exhibit a range of hematopoietic abnormalities, to elucidate the cellintrinsic contribution of SHIP1 ablation to the disease phenotype, I induced K/BxN mediatedarthritis in mice with lineage restricted deletion of SHIP1. Mice with a neutrophil/macrophage-restricted loss of SHIP1 (LysMcre), like global SHIP1 knock-out mice,displayed an alternatively activated ʻM2ʼ biased macrophage phenotype, and developedexacerbated disease. Neutrophil-restricted loss of SHIP1 (GEcre) was also sufficient toexacerbate disease and resulted in earlier disease onset. In order to identify how the loss ofSHIP1 in neutrophils results in heightened disease severity, I performed a series of in vitroexperiments utilizing polymorphonuclear leukocytes freshly isolated from bone marrow.While we cannot exclude that SHIP1 may be playing additional roles in neutrophil functions,I report that SHIP1 plays a role in attenuating responsiveness of neutrophils to GPCR andFcγR ligation, two families of receptors that are necessary for induction and amplification ofrheumatoid arthritis in the K/BxN serum transfer model.


  • IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection (2019)
    Bernard C. Lo and Samuel B. Shin and Diana Canals Hernaez and Ido Refaeli and Hong B. Yu and Verena Goebeler and Alissa Cait and William W. Mohn and Bruce A. Vallance and Kelly M. McNagny
    The Journal of Immunology ji1801308
  • Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner (2018)
    Abdulrahman M. Saadalla and Abu Osman and Michael F. Gurish and Kristen L. Dennis and Nichole R. Blatner and Abdulmohammad Pezeshki and Kelly M. McNagny and Hilde Cheroutre and Fotini Gounari and Khashayarsha Khazaie
    Proceedings of the National Academy of Sciences 115 (7) 1588--1592
  • Mast Cells in Human Health and Disease (2015)

    DeBruin, Erin J and Gold, Matthew and Lo, Bernard C and Snyder, Kimberly and Cait, Alissa and Lasic, Nikola and Lopez, Martin and McNagny, Kelly M and Hughes, Michael R
    Mast Cells 93--119

  • Measurement of Mast Cell Surface Molecules BY High-Throughput Immunophenotyping Using Transcription (HIT) (2015)

    Haddon, D James and Jarrell, Justin A and Hughes, Michael R and Snyder, Kimberly and McNagny, Kelly M and Kattah, Michael G and Utz, Paul J
    Mast Cells 381--400

  • Genes, the environment and personalized medicine (2014)
    Carlsten, Chris and Brauer, Michael and Brinkman, Fiona and Brook, Jeffrey and Daley, Denise and McNagny, Kelly and Pui, Mandy and Royce, Diana and Takaro, Tim and Denburg, Judah
    EMBO reports
  • Group 2 innate lymphoid cells Are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation (2014)
    Halim, Timotheus YF and Steer, Catherine A and Mathä, Laura and Gold, Matthew J and Martinez-Gonzalez, Itziar and McNagny, Kelly M and McKenzie, Andrew NJ and Takei, Fumio
    Immunity 40 (3) 425--435
  • Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, T< sub> H 2-inducing allergen exposures (2014)
    Gold, Matthew J and Antignano, Frann and Halim, Timotheus YF and Hirota, Jeremy A and Blanchet, Marie-Renee and Zaph, Colby and Takei, Fumio and McNagny, Kelly M
    Journal of Allergy and Clinical Immunology 133 (4) 1142--1148
  • ILC2+ DC= Th2, group 2 innate lymphoid cell derived IL-13 is essential for efficient T helper 2 cell differentiation in allergic lung inflammation.(HYP6P. 258) (2014)

    Halim, Timotheus and Steer, Catherine and Matha, Laura and Gold, Matthew and Martinez-Gonzalez, Itziar and McNagny, Kelly and McKenzie, Andrew and Takei, Fumio
    The Journal of Immunology 192 (1 Sup) 118--3

  • Impairing Eukaryotic Elongation Factor 2 Kinase (eEF2K) Activity Decreases Atherosclerotic Plaque Formation (2014)

    Zhang, Peng and Riazy, Maziar and Gold, Matthew and Tsai, Shu-Huei and McNagny, Kelly and Proud, Christopher and Duronio, Vincent
    Canadian Journal of Cardiology

  • Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation (2014)
    Zhang, P. and Riazy, M. and Gold, M. and Tsai, S. H. and McNagny, K. and Proud, C. and Duronio, V.
    Can J Cardiol 30 (12) 1684-8
  • Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation (2014)
    Antignano, Frann and Burrows, Kyle and Hughes, Michael R and Han, Jonathan M and Kron, Ken J and Penrod, Nadia M and Oudhoff, Menno J and Wang, Steven Kai Hao and Min, Paul H and Gold, Matthew J and others
    The Journal of clinical investigation 124 (5) 0--0
  • Mutant Mice and Animal Models of Airway Allergic Disease (2014)
    Blanchet, Marie-Renée and Gold, Matthew and McNagny, Kelly M
    Eosinophils 295--308
  • Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases (2014)

    Russell, Shannon L and Gold, Matthew J and Reynolds, Lisa A and Willing, Benjamin P and Dimitriu, Pedro and Thorson, Lisa and Redpath, Stephen A and Perona-Wright, Georgia and Blanchet, Marie-Renée and Mohn, William W and others
    Journal of Allergy and Clinical Immunology

  • Podocalyxin Regulates Murine Lung Vascular Permeability by Altering Endothelial Cell Adhesion (2014)

    Debruin, Erin J and Hughes, Michael R and Sina, Christina and Liu, Alex and Cait, Jessica and Jian, Zhiqi and Lopez, Martin and Lo, Bernard and Abraham, Thomas and McNagny, Kelly M
    PloS one 9 (10) e108881

  • The NLRP3 Inflammasome/IL-1RI Axis Mediates Innate Immune but Not Adaptive Immune Responses Following PM10 Exposure (2014)

    Hirota, Jeremy A and Gold, Matthew J and Hiebert, Paul R and Parkinson, Leigh G and Wee, Tracee and Smith, Dirk and Hansbro, Phil M and Carlsten, Chris and VanEeden, Stephan and Sin, Don D and others
    American journal of respiratory cell and molecular biology (ja)

  • A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue (2013)

    Scherberich, Arnaud and Di Di Maggio, Nunzia and McNagny, Kelly M
    World journal of stem cells 5 (1) 1

  • Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele (2013)

    Anderson, Nicole M and Javadi, Mojib and Berndl, Elizabeth and Berberovic, Zorana and Bailey, Monica L and Huang, Kai and Flenniken, Ann M and Osborne, Lucy R and Adamson, S Lee and Rossant, Janet and others
    PloS one 8 (9) e75472

  • Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury (2013)
    Hirota, Jeremy A and Hiebert, Paul R and Gold, Matt and Wu, Dan and Graydon, Colin and Smith, Jane Ann and Ask, Kjetil and McNagny, Kelly and Granville, David J and Knight, Darryl A
    American journal of respiratory cell and molecular biology 49 (3) 453--462
  • Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma (2013)

    Russell, Shannon L and Gold, Matthew J and Willing, Benjamin P and Thorson, Lisa and McNagny, Kelly M and Finlay, Brett B and others
    Gut Microbes 4 (2) 158--164

  • Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation (2013)
    Aloyouni, Sheka Yagub and Segeritz, Charis-Patricia and Sherrid, Ashley M and Gold, Matthew J and Loeffler, Daniela IM and Blanchet, Marie-Renée and Cai, Bing and Hirota, Jeremy and McNagny, Kelly M and Kollmann, Tobias R
    Allergy, Asthma & Immunology Research 6
  • Requirement for core 2 o-glycans for optimal resistance to helminth infection (2013)

    Mullaly, Sarah C and Oudhoff, Menno J and Min, Paul H and Burrows, Kyle and Antignano, Frann and Rattray, David G and Chenery, Alistair and McNagny, Kelly M and Ziltener, Hermann J and Zaph, Colby
    PloS one 8 (3) e60124

  • SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens (2013)

    Sham, Ho Pan and Yu, Emily Yi Shan and Gulen, Muhammet F and Bhinder, Ganive and Stahl, Martin and Chan, Justin M and Brewster, Lara and Morampudi, Vijay and Gibson, Deanna L and Hughes, Michael R and others
    PLoS pathogens 9 (8) e1003539

  • Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes (2012)
    Kodippili, Gayani C and Spector, Jeff and Hale, Jacob and Giger, Katie and Hughes, Michael R and McNagny, Kelly M and Birkenmeier, Connie and Peters, Luanne and Ritchie, Ken and Low, Philip S
    Journal of Biological Chemistry 287 (6) 4129--4138
  • Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens (2012)
    Anderson, Nicole M and Berberovic, Zorana and Berndl, Elizabeth and Bailey, Monica L and Flenniken, Ann M and Osborne, Lucy R and Adamson, S Lee and Rossant, Janet and Wang, Chen and Minden, Mark D and others
    Experimental hematology 40 (1) 48--60
  • Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma (2012)
    Russell, Shannon L and Gold, Matthew J and Hartmann, Martin and Willing, Benjamin P and Thorson, Lisa and Wlodarska, Marta and Gill, Navkiran and Blanchet, Marie-Renée and Mohn, William W and McNagny, Kelly M and others
    EMBO reports 13 (5) 440--447
  • IL-7R\$α\$ and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis (2012)

    Maltby, Steven and DeBruin, Erin J and Bennett, Jami and Gold, Matthew J and Tunis, Matthew C and Jian, Zhiqi and Marshall, Jean S and McNagny, Kelly M and others
    Allergy, Asthma \& Clinical Immunology 8 (1) 15

  • IL-7R$α$ and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis (2012)

    Maltby, Steven and DeBruin, Erin J and Bennett, Jami and Gold, Matthew J and Tunis, Matthew C and Jian, Zhiqi and Marshall, Jean S and McNagny, Kelly M and others
    Allergy, Asthma & Clinical Immunology 8 (1) 15

  • Mouse models to evaluate the function of genes associated with allergic airway disease (2012)
    Blanchet, Marie-Renee and Gold, Matthew J and McNagny, Kelly M
    Current opinion in allergy and clinical immunology 12 (5) 467--474
  • Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection (2012)
    Hadidi, S and Antignano, F and Hughes, MR and Wang, SKH and Snyder, K and Sammis, GM and Kerr, WG and McNagny, KM and Zaph, C
    Mucosal immunology
  • Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation (2012)
    Halim, Timotheus YF and MacLaren, Aric and Romanish, Mark T and Gold, Matthew J and McNagny, Kelly M and Takei, Fumio
    Immunity 37 (3) 463--474
  • The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma (2012)
    Cipollone, Jane A and Graves, Marcia L and Köbel, Martin and Kalloger, Steve E and Poon, Tak and Gilks, C Blake and McNagny, Kelly M and Roskelley, Calvin D
    Clinical & experimental metastasis 29 (3) 239--252
  • A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis (2011)
    Hughes, Michael R and Anderson, Nicole and Maltby, Steven and Wong, Justin and Berberovic, Zorana and Birkenmeier, Connie S and Haddon, D James and Garcha, Kamal and Flenniken, Ann and Osborne, Lucy R and others
    Experimental hematology 39 (3) 305--320
  • CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis (2011)
    Blanchet, Marie-Renée and Bennett, Jami L and Gold, Matthew J and Levantini, Elena and Tenen, Daniel G and Girard, Melissa and Cormier, Yvon and McNagny, Kelly M
    American journal of respiratory and critical care medicine 184 (6) 687--698
  • CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration (2011)
    Alfaro, Leslie Ann So and Dick, Sarah A and Siegel, Ashley L and Anonuevo, Adam S and McNagny, Kelly M and Megeney, Lynn A and Cornelison, Dawn DW and Rossi, Fabio
    Stem cells 29 (12) 2030--2041
  • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool (2011)
    Ajami, Bahareh and Bennett, Jami L and Krieger, Charles and McNagny, Kelly M and Rossi, Fabio MV
    Nature neuroscience 14 (9) 1142--1149
  • NUP98-HOXA10hd-expanded hematopoietic stem cells efficiently reconstitute bone marrow of mismatched recipients and induce tolerance (2011)
    Even, Y and Bennett, JL and Sekulovic, S and So, L and Yi, L and McNagny, K and Humphries, RK and Rossi, FMV
    Cell transplantation 20 (7) 1099--1108
  • Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration (2011)

    Maltby, Steven and Freeman, Spencer and Gold, Matthew J and Baker, Jennifer HE and Minchinton, Andrew I and Gold, Michael R and Roskelley, Calvin D and McNagny, Kelly M
    PloS one 6 (4) e18160

  • SHIP represses Th2 skewing by inhibiting IL-4 production from basophils (2011)
    Kuroda, Etsushi and Antignano, Frann and Ho, Victor W and Hughes, Michael R and Ruschmann, Jens and Lam, Vivian and Kawakami, Toshiaki and Kerr, William G and McNagny, Kelly M and Sly, Laura M and others
    The Journal of Immunology 186 (1) 323--332
  • Adhesion molecules in experimental peanut allergy (2010)

    Bennett, Jami and Maltby, Steven and Frohwerk, Erin and Jian, Kay and Merkens, Helen and Tunis, Mathew and McNagny, Kelly
    Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology 6 (Suppl) P10

  • CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis (2010)
    Maltby, Steven and Wohlfarth, Carolin and Gold, Matthew and Zbytnuik, Lori and Hughes, Michael R and McNagny, Kelly M
    The American journal of pathology 177 (3) 1244--1254
  • CD34 mediates intestinal inflammation in Salmonella-infected mice (2010)
    Grassl, Guntram A and Faustmann, Marco and Gill, Navkiran and Zbytnuik, Lori and Merkens, Helen and So, Leslie and Rossi, Fabio M and McNagny, Kelly M and Finlay, B Brett
    Cellular microbiology 12 (11) 1562--1575
  • Communication-The changing landscape of human--animal chimera research: A Canadian regulatory perspective (2010)
    Bordet, Sylvie and Bennett, Jami and Knoppers, Bartha Maria and McNagny, Kelly M
    Stem cell research 4 (1) 10--16
  • Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling (2010)
    Gibson, Deanna L and Montero, Marinieve and Ropeleski, Mark J and Bergstrom, Kirk SB and Ma, Caixia and Ghosh, Sanjoy and Merkens, Helen and Huang, Jingtian and MÃ¥nsson, Lisa E and Sham, Ho Pan and others
    Gastroenterology 139 (4) 1277--1288
  • Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability (2010)
    Blanchet, Marie-Renée and Gold, Matthew and Maltby, Steven and Bennett, Jami and Petri, Björn and Kubes, Paul and Lee, David M and McNagny, Kelly M
    The journal of immunology 184 (3) 1292--1299
  • Myh9 (Q1443L) Is a Novel Mouse Model of MYH9-Related Disorders. (2010)

    Anderson, Nicole M and Berndl, Elizabeth and Berberovic, Zorana and Reheman, Adili and Brown, Trecia A and Bailey, Monica L and Flenniken, Ann M and Osborne, Lucy R and Adamson, S Lee and Rossant, Janet and others
    Blood 116 (21) 1047--1048

  • Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation (2010)

    Vitureira, Nathalia and Andrés, Rosa and Pérez-Mart’\\inez, Esther and Mart’\\inez, Albert and Bribián, Ana and Blasi, Juan and Chelliah, Shierley and López-Doménech, Guillermo and De Castro, Fernando and Burgaya, Ferran and others
    PloS one 5 (8) e12003

  • The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma (2010)
    Naus, Silvia and Blanchet, Marie-Renée and Gossens, Klaus and Zaph, Colby and Bartsch, Jörg W and McNagny, Kelly M and Ziltener, Hermann J
    American journal of respiratory and critical care medicine 181 (12) 1318--1328
  • Allergy, Asthma \& Clinical Immunology (2009)

    Blanchet, Marie-Renee and McNagny, Kelly M

  • Allergy, Asthma & Clinical Immunology (2009)

    Blanchet, Marie-Renee and McNagny, Kelly M

  • Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis (2009)
    Bennett, Jami L and Blanchet, Marie-Renée and Zhao, Linlin and Zbytnuik, Lori and Antignano, Frann and Gold, Matthew and Kubes, Paul and McNagny, Kelly M
    The Journal of Immunology 182 (9) 5507--5514
  • CD34 is a key regulator of hematopoietic stem cell trafficking to bone marrow and mast cell progenitor trafficking in the periphery (2009)
    Nielsen, Julie S and McNagny, Kelly M
    Microcirculation 16 (6) 487--496
  • CD34 Mediates Dendritic Cell Trafficking in Hypersensitivity Pneumonitis. (2009)

    Bennett, Jami L and Blanchet, Marie Renee and Girard, Melissa and Cormier, Yvon and McNagny, Kelly M
    Am J Respir Crit Care Med 179 A4284

  • iPS cells: mapping the policy issues (2009)
    Zarzeczny, Amy and Scott, Christopher and Hyun, Insoo and Bennett, Jami and Chandler, Jennifer and Chargé, Sophie and Heine, Heather and Isasi, Rosario and Kato, Kazuto and Lovell-Badge, Robin and others
    Cell 139 (6) 1032--1037
  • Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation (2009)
    Maltby, Steven and Khazaie, Khashayarsha and McNagny, Kelly M
    Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1796 (1) 19--26
  • Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery (2009)
    Maltby, Steven and Hughes, Michael R and Zbytnuik, Lori and Paulson, Robert F and McNagny, Kelly M
    Experimental hematology 37 (1) 10--18
  • Prion protein expression and release by mast cells after activation (2009)

    Haddon, D James and Hughes, Michael R and Antignano, Frann and Westaway, David and Cashman, Neil R and McNagny, Kelly M
    Journal of Infectious Diseases 200 (5) 827--831

  • SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo (2009)

    Haddon, D James and Antignano, Frann and Hughes, Michael R and Blanchet, Marie-Renée and Zbytnuik, Lori and Krystal, Gerald and McNagny, Kelly M
    The Journal of Immunology 183 (1) 228--236

  • The molecular basis of vascular lumen formation in the developing mouse aorta (2009)

    Strilić, Boris and Kučera, Tomáš and Eglinger, Jan and Hughes, Michael R and McNagny, Kelly M and Tsukita, Sachiko and Dejana, Elisabetta and Ferrara, Napoleone and Lammert, Eckhard
    Developmental cell 17 (4) 505--515

  • The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas (2009)

    Lin, KBL and Tan, P and Freeman, SA and Lam, M and McNagny, KM and Gold, MR
    Oncogene 29 (4) 608--615

  • The role of podocalyxin in health and disease (2009)

    Nielsen, Julie S and McNagny, Kelly M
    Journal of the American Society of Nephrology 20 (8) 1669--1676

  • Novel functions of the CD34 family (2008)

    Nielsen, Julie S and McNagny, Kelly M
    Journal of Cell Science 121 (22) 3683--3692

  • The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1 (2008)

    Kelly, Margaret M and McNagny, Kelly and Williams, David L and van Rooijen, Nico and Maxwell, Lori and Gwozd, Carol and Mody, Christopher H and Kubes, Paul
    American journal of respiratory cell and molecular biology 38 (2) 227--238

  • CD34 facilitates the development of allergic asthma (2007)

    Blanchet, Marie-Renée and Maltby, Steven and Haddon, D James and Merkens, Helen and Zbytnuik, Lori and McNagny, Kelly M
    Blood 110 (6) 2005--2012

  • Influence of host irradiation on long-term engraftment by CD34-deficient hematopoietic stem cells (2007)

    Nielsen, Julie S and McNagny, Kelly M
    Blood 110 (3) 1076--1077

  • Mast cells are an essential hematopoietic component for polyp development (2007)

    Gounaris, Elias and Erdman, Susan E and Restaino, Clifford and Gurish, Michael F and Friend, Daniel S and Gounari, Fotini and Lee, David M and Zhang, Guoying and Glickman, Jonathan N and Shin, Kichul and others
    Proceedings of the National Academy of Sciences 104 (50) 19977--19982

  • The CD34-related molecule podocalyxin is a potent inducer of microvillus formation (2007)

    Nielsen, Julie S and Graves, Marcia L and Chelliah, Shierley and Vogl, A Wayne and Roskelley, Calvin D and McNagny, Kelly M
    PLoS One 2 (2) e237

  • Beyond mere markers (2006)

    Furness, Sebastian George Barton and McNagny, Kelly
    Immunologic research 34 (1) 13--32

  • Hematopoietic stem cells do not engraft with absolute efficiencies (2006)

    Camargo, Fernando D and Chambers, Stuart M and Drew, Erin and McNagny, Kelly M and Goodell, Margaret A
    Blood 107 (2) 501--507

  • Na+/H+ Exchanger Regulatory Factor-1 Is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins (2006)

    Tan, Poh C and Furness, Sebastian GB and Merkens, Helen and Lin, Shujun and McCoy, Marcia L and Roskelley, Calvin D and Kast, Jürgen and McNagny, Kelly M
    Stem Cells 24 (5) 1150--1161

  • CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution (2005)

    Drew, Erin and Merzaban, Jasmeen S and Seo, Wooseok and Ziltener, Hermann J and McNagny, Kelly M
    Immunity 22 (1) 43--57

  • CD34 expression by mast cells: of mice and men (2005)

    Drew, Erin and Huettner, Claudia S and Tenen, Daniel G and McNagny, Kelly M
    Blood 106 (5) 1885--1887

  • Pattern of expression of the podocalyxin gene in the mouse brain during development (2005)

    Vitureira, Nathalia and McNagny, Kelly and Soriano, Eduardo and Burgaya, Ferran
    Gene expression patterns 5 (3) 349--354

  • Platelets express functional Toll-like receptor-4 (2005)

    Andonegui, Graciela and Kerfoot, Steven M and McNagny, Kelly and Ebbert, Kirsten VJ and Patel, Kamala D and Kubes, Paul
    Blood 106 (7) 2417--2423

  • Podocalyxin A marker of blasts in acute leukemia (2005)

    Kelley, Todd W and Huntsman, David and McNagny, Kelly M and Roskelley, Calvin D and Hsix, Eric D
    American journal of clinical pathology 124 (1) 134--142

  • Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells (2005)

    Doyonnas, Regis and Nielsen, Julie S and Chelliah, Shierley and Drew, Erin and Hara, Takahiko and Miyajima, Atsushi and McNagny, Kelly M
    Blood 105 (11) 4170--4178

  • Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression (2004)

    Somasiri, Aruna and Nielsen, Julie S and Makretsov, Nikita and McCoy, Marcia L and Prentice, Leah and Gilks, C Blake and Chia, Stephen K and Gelmon, Karen A and Kershaw, David B and Huntsman, David G and others
    Cancer research 64 (15) 5068--5073

  • E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors (2003)

    McNagny, Kelly M and Graf, Thomas
    Blood 101 (3) 1103--1110

  • Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes (2002)

    Nielsen, Julie S and Doyonnas, Regis and McNagny, Kelly M
    Cells Tissues Organs 171 (1) 44--63

  • CD34 is a specific marker of mature murine mast cells (2002)

    Drew, Erin and Merkens, Helen and Chelliah, Shierley and Doyonnas, Regis and McNagny, Kelly M
    Experimental hematology 30 (10) 1211--1218

  • Making eosinophils through subtle shifts in transcription factor expression (2002)

    McNagny, Kelly and Graf, Thomas
    The Journal of experimental medicine 195 (11) F43--F47

  • The v-erbA oncogene blocks expression of alpha2/beta1 integrin a normal inhibitor of erythroid progenitor proliferation. (2002)

    Mey, Anne and Gandrillon, Olivier and McNagny, Kelly M and Clegg, Dennis O and Samarut, Jacques
    Oncogene 21 (18) 2864--2872

  • Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin (2001)

    Doyonnas, Regis and Kershaw, David B and Duhme, Christian and Merkens, Helen and Chelliah, Shierley and Graf, Thomas and McNagny, Kelly M
    The Journal of experimental medicine 194 (1) 13--28

  • Surface molecules involved in avian T-cell progenitor migration and differentiation (2000)

    Ody, Christiane and Alais, S and Corbel, C and McNagny, KM and Davison, TF and Vainio, O and Imhof, BA and Dunon, D
    Developmental immunology 7 (2-4) 267

  • Characterization of prethymic progenitors within the chicken embryo (1999)

    Lampisuo, Miia and Liippo, Jussi and Vainio, Olli and McNagny, Kelly M and Kulmala, Jarmo and Lassila, Olli
    International immunology 11 (1) 63--69

  • Distinct C/EBP functions are required for eosinophil lineage commitment and maturation (1998)

    Nerlov, Claus and McNagny, Kelly M and Döderlein, Gabriele and Kowenz-Leutz, Elisabeth and Graf, Thomas
    Genes & development 12 (15) 2413--2423

  • Regulation of eosinophil-specific gene expression by a C/EBP--Ets complex and GATA-1 (1998)

    McNagny, Kelly M and Sieweke, Michael H and Döderlein, Gabriele and Graf, Thomas and Nerlov, Claus
    The EMBO Journal 17 (13) 3669--3680

  • Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors (1997)

    McNagny, Kelly M and Pettersson, Inger and Rossi, Fabio and Flamme, Ingo and Shevchenko, Andrej and Mann, Matthias and Graf, Thomas
    The Journal of cell biology 138 (6) 1395--1407

  • Acute avian leukemia viruses as tools to study hematopoietic cell differentiation (1996)

    McNagny, KM and Graf, T 143--162

  • Excision of Ets by an inducible site-specific recombinase causes differentiation of Myb--Ets-transformed hematopoietic progenitors (1996)

    Rossi, Fabio and McNagny, Kelly M and Logie, Colin and Stewart, A Francis and Graf, Thomas
    Current Biology 6 (7) 866--872

  • HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. (1996)

    Vainio, O and Dunon, D and Aissi, F and Dangy, JP and McNagny, KM and Imhof, BA
    The Journal of cell biology 135 (6) 1655--1668

  • The eosinophil-specific cell surface antigen, EOS47, is a chicken homologue of the oncofetal antigen melanotransferrin (1996)

    McNagny, Kelly M and Rossi, Fabio and Smith, Graham and Graf, Thomas
    Blood 87 (4) 1343--1352

  • Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen (1995)

    Bradshaw, Amy D and McNagny, Kelly M and Gervin, Dennis B and Cann, Gordon M and Graf, Thomas and Clegg, Dennis O
    Development 121 (11) 3593--3602

  • v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors. (1995)

    Frampton, J and McNagny, K and Sieweke, M and Philip, A and Smith, G and Graf, T
    The EMBO journal 14 (12) 2866

  • A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets. (1994)

    Kraut, Norbert and Frampton, Jon and McNagny, Kelly M and Graf, Thomas
    Genes & development 8 (1) 33--44

  • Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies. (1992)

    McNagny, KM and Lim, F and Grieser, S and Graf, T
    Leukemia 6 (10) 975--984

  • Chicken “erythroid” cells transformed by the Gag-Myb-Ets-encoding E26 leukemia virus are multipotent (1992)

    Graf, Thomas and McNagny, Kelly and Brady, Gerard and Frampton, Jonathan
    Cell 70 (2) 201--213

  • Reticular cells in peripheral lymphoid tissues express the phosphatidylinositol-linked BP-3 antigen (1991)

    McNagny, Kelly M and Bucy, R Pat and Cooper, Max D
    European journal of immunology 21 (2) 509--515

  • BP-3 alloantigen. A cell surface glycoprotein that marks early B lineage cells and mature myeloid lineage cells in mice. (1988)

    McNAGNY, KELLY M and Cazenave, PIERRE-ANDRE and Cooper, MD
    The Journal of Immunology 141 (8) 2551--2556

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