Maria Elishaev
Doctor of Philosophy in Pathology and Laboratory Medicine (PhD)
Research Topic
Efferocytosis function in atherosclerotic lesions
Ying Wang
Assistant Professor
Research Classification
Research Interests
atherosclerosis
Diabetic cardiomyopathy
Vascular biology
Spatial 'Omics'
Drug repurposing and therapeutic design
Disease modeling
Digital Pathology
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Endotyping biobank human specimens
Multiplex imaging-spatial proteomics
Spatial gene expression
Single-cell and bulk RNA sequencing
Ex vivo tissue and primary cell culture
Lineage tracing and transgenic in vivo models
bioinformatics
Computational modeling
Recruitment
Master's students
Doctoral students
2024
2025
1. Finding therapeutic targets to remove diseased cells in the atherosclerotic lesions
2. Drug repurposing for atherosclerotic disease
3. Developing spatial and single-cell endotyping technologies for cardiovascular tissues
Current opportunities: https://www.hli.ubc.ca/careers/
Complete these steps before you reach out to a faculty member!
Check requirements
- Familiarize yourself with program requirements. You want to learn as much as possible from the information available to you before you reach out to a faculty member. Be sure to visit the graduate degree program listing and program-specific websites.
- Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. This is either indicated in the program profile under "Admission Information & Requirements" - "Prepare Application" - "Supervision" or on the program website.
Focus your search
- Identify specific faculty members who are conducting research in your specific area of interest.
- Establish that your research interests align with the faculty member’s research interests.
- Read up on the faculty members in the program and the research being conducted in the department.
- Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Be certain that their research is indeed what you are hoping to study.
Make a good impression
- Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles.
- Do not send non-specific, mass emails to everyone in the department hoping for a match.
- Address the faculty members by name. Your contact should be genuine rather than generic.
- Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. The supervision enquiry form guides you with targeted questions. Ensure to craft compelling answers to these questions.
- Highlight your achievements and why you are a top student. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest.
- Demonstrate that you are familiar with their research:
- Convey the specific ways you are a good fit for the program.
- Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting.
- Be enthusiastic, but don’t overdo it.
Attend an information session
G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application.
ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
These videos contain some general advice from faculty across UBC on finding and reaching out to a potential thesis supervisor.
Publications
- Proefferocytic therapy promotes transforming growth factor-β signaling and prevents aneurysm formation (2018)
Circulation, 137 (7), 750-753 - Intrinsic and extrinsic regulation of cardiac lipoprotein lipase following diabetes (2015)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1851 (2), 163-171 - Endothelial cell heparanase taken up by cardiomyocytes regulates lipoprotein lipase transfer to the coronary lumen after diabetes (2014)
Diabetes, 63 (8), 2643-2655 - Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1 (2014)
American Journal of Physiology - Endocrinology and Metabolism, 306 (11) - A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice (2013)
Hepatology, 57 (2), 543-554 - Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes (2013)
Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (5), 894-902 - Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase (2013)
Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (12), 2830-2838 - Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1 (2012)
Journal of Molecular and Cellular Cardiology, 53 (5), 677-686 - Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells (2012)
Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (2), 406-414 - Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy (2012)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1821 (5), 800-808 - Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1-iNOS-CD36 pathway (2011)
Free Radical Biology and Medicine, 51 (2), 352-363 - Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly (2011)
Diabetes, 60 (8), 2041-2050 - Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization (2010)
Cardiovascular Research, 87 (1), 127-136 - The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis (2010)
Endocrinology, 151 (5), 2306-2318
Current Students & Alumni
This is a small sample of students and/or alumni that have been supervised by this researcher. It is not meant as a comprehensive list.
If this is your researcher profile you can log in to the Faculty & Staff portal to update your details and provide recruitment preferences.