Maria Elishaev
Doctor of Philosophy in Pathology and Laboratory Medicine (PhD)
Research Topic
Efferocytosis function in atherosclerotic lesions
Ying Wang
Assistant Professor
Research Classification
Research Interests
atherosclerosis
Diabetic cardiomyopathy
Vascular biology
Spatial 'Omics'
Drug repurposing and therapeutic design
Disease modeling
Digital Pathology
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Endotyping biobank human specimens
Multiplex imaging-spatial proteomics
Spatial gene expression
Single-cell and bulk RNA sequencing
Ex vivo tissue and primary cell culture
Lineage tracing and transgenic in vivo models
bioinformatics
Computational modeling
Recruitment
Master's students
Doctoral students
2024
2025
1. Finding therapeutic targets to remove diseased cells in the atherosclerotic lesions
2. Drug repurposing for atherosclerotic disease
3. Developing spatial and single-cell endotyping technologies for cardiovascular tissues
Current opportunities: https://www.hli.ubc.ca/careers/
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ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
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Publications
- Proefferocytic therapy promotes transforming growth factor-β signaling and prevents aneurysm formation (2018)
Circulation, 137 (7), 750-753 - Intrinsic and extrinsic regulation of cardiac lipoprotein lipase following diabetes (2015)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1851 (2), 163-171 - Endothelial cell heparanase taken up by cardiomyocytes regulates lipoprotein lipase transfer to the coronary lumen after diabetes (2014)
Diabetes, 63 (8), 2643-2655 - Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1 (2014)
American Journal of Physiology - Endocrinology and Metabolism, 306 (11) - A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice (2013)
Hepatology, 57 (2), 543-554 - Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes (2013)
Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (5), 894-902 - Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase (2013)
Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (12), 2830-2838 - Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1 (2012)
Journal of Molecular and Cellular Cardiology, 53 (5), 677-686 - Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells (2012)
Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (2), 406-414 - Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy (2012)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1821 (5), 800-808 - Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1-iNOS-CD36 pathway (2011)
Free Radical Biology and Medicine, 51 (2), 352-363 - Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly (2011)
Diabetes, 60 (8), 2041-2050 - Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization (2010)
Cardiovascular Research, 87 (1), 127-136 - The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis (2010)
Endocrinology, 151 (5), 2306-2318
Current Students & Alumni
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