Genetic influences of lipoprotein metabolism on atherosclerosis and sepsis
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1. SAVE BC (www.savebc.ca) us a provincial study of families with extremely premature cardiovascular disease, aimed at identifying molecular causes of this condition and reducing the burden of premature cardiovascular disease.
2. Pharmacogenomics of adverse drug reactions. We are using human stem cells to study the pharmacogenetic mechanisms of specific adverse drug reactions. This work will lead to new approaches to identify patients at risk of suffering from adverse drug reactions, and the development of safer, more effective medications.
3. Inherited dyslipidemias. We have one of the largest and most established registries in Canada of patients with Familial Hypercholesterolemia, a common cause of premature CVD which is under-recognized and under-treated. We are investigating the use of genetic testing to improve the diagnosis of patients with this condition, and understand the determinants of cardiovascular disease risk in these patients.