Mark Trinder
Doctor of Medicine and Doctor of Philosophy (MDPhD)
Research Topic
Genetic influences of lipoprotein metabolism on atherosclerosis and sepsis
Liam Brunham
Assistant Professor
Research Classification
Genetic Diseases
Cardiovascular Diseases
Lipid Disorders
Stem Cells and Organogenesis
Relevant Degree Programs
Research Methodology
Next generation sequencing
Genome editing
Induced pluripotent stem cells
Genome wide association studies
clinical trials
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1. SAVE BC (www.savebc.ca) us a provincial study of families with extremely premature cardiovascular disease, aimed at identifying molecular causes of this condition and reducing the burden of premature cardiovascular disease.
2. Pharmacogenomics of adverse drug reactions. We are using human stem cells to study the pharmacogenetic mechanisms of specific adverse drug reactions. This work will lead to new approaches to identify patients at risk of suffering from adverse drug reactions, and the development of safer, more effective medications.
3. Inherited dyslipidemias. We have one of the largest and most established registries in Canada of patients with Familial Hypercholesterolemia, a common cause of premature CVD which is under-recognized and under-treated. We are investigating the use of genetic testing to improve the diagnosis of patients with this condition, and understand the determinants of cardiovascular disease risk in these patients.
Current Students & Alumni
This is a small sample of students and/or alumni that have been supervised by this researcher. It is not meant as a comprehensive list.
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