Relevant Thesis-Based Degree Programs
Metabolites directly reflect genetic, physiological, and environmental changes and can provide a reliable readout for therapeutic effectiveness. Pharmacometabolomics refers to the study of measuring metabolite changes in response to drug therapy. In the assessment of cancer, metabolites excreted from tumors can be measured by routine non-invasive sampling of plasma and urine. Projects in the Velenosi lab use state-of-the-art technologies including metabolomics, lipidomics and stable-isotope tracing, focusing on two major research streams:
- Developing computational methods for improving mass spectrometry-based metabolomics, lipidomics and stable isotope tracing.
- Applying these techniques to cutting-edge cancer models, including patient derived xenografts, to identify and characterize metabolic biomarkers and therapeutic targets that can improve therapies for cancer patients.
Complete these steps before you reach out to a faculty member!
- Familiarize yourself with program requirements. You want to learn as much as possible from the information available to you before you reach out to a faculty member. Be sure to visit the graduate degree program listing and program-specific websites.
- Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. This is either indicated in the program profile under "Admission Information & Requirements" - "Prepare Application" - "Supervision" or on the program website.
- Identify specific faculty members who are conducting research in your specific area of interest.
- Establish that your research interests align with the faculty member’s research interests.
- Read up on the faculty members in the program and the research being conducted in the department.
- Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Be certain that their research is indeed what you are hoping to study.
- Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles.
- Do not send non-specific, mass emails to everyone in the department hoping for a match.
- Address the faculty members by name. Your contact should be genuine rather than generic.
- Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. The supervision enquiry form guides you with targeted questions. Ensure to craft compelling answers to these questions.
- Highlight your achievements and why you are a top student. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest.
- Demonstrate that you are familiar with their research:
- Convey the specific ways you are a good fit for the program.
- Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting.
- Be enthusiastic, but don’t overdo it.
G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application.
ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
These videos contain some general advice from faculty across UBC on finding and reaching out to a potential thesis supervisor.
- Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells (2022)
- Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer (2022)
- Postprandial plasma lipidomics reveal specific alteration of hepatic-derived diacylglycerols in non-alcoholic fatty liver disease. (2022)
- Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. (2020)
- Abstract 4366: Characterization of diacetylspermine as a metabolic urinary biomarker in breast cancer using patient-derived xenografts (2019)
Molecular and Cellular Biology / Genetics,
- Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications (2019)
Journal of Renal Nutrition, 29 (1), 55-64
- The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats (2019)
Pharmacology Research and Perspectives, 7 (3)
- Untargeted metabolomics reveals N, N, N-trimethyl-L-alanyl-L-proline betaine (TMAP) as a novel biomarker of kidney function (2019)
Scientific Reports, 9 (1)
- Extrahepatic PPAR modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice (2018)
Journal of Lipid Research, 59 (11), 2140-2152
- Mediterranean diet score: Associations with metabolic products of the intestinal microbiome, carotid plaque burden, and renal function (2018)
Nutrients, 10 (6)
- Metabolic products of the intestinal microbiome and extremes of atherosclerosis (2018)
Atherosclerosis, 273, 91-97
- β-blocker dialyzability in maintenance hemodialysis patients a randomized clinical trial (2018)
Clinical Journal of the American Society of Nephrology, 13 (4), 604-611
- Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats (2016)
Scientific Reports, 6
- Untargeted plasma and tissue metabolomics in rats with chronic kidney disease given AST-120 (2016)
Scientific Reports, 6
- Effect of CKD and dialysis modality on exposure to drugs cleared by nonrenal mechanisms (2015)
American Journal of Kidney Diseases, 65 (4), 574-582
- Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease (2015)
British Journal of Pharmacology, 172 (1), 201-213
- CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation (2014)
Molecular and Cellular Biochemistry, 394 (1-2), 237-246
- Decreased nuclear receptor activity and epigenetic modulation associates with down-regulation of hepatic drug-metabolizing enzymes in chronic kidney disease (2014)
FASEB Journal, 28 (12), 5388-5397
- Enzymatic and non-enzymatic mechanisms of dimesna metabolism (2014)
Amino Acids, 47 (3), 511--523
- N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes (2014)
Cardiovascular Diabetology, 13 (1)
- Pharmacokinetic considerations in chronic kidney disease and patients requiring dialysis (2014)
Expert Opinion on Drug Metabolism & Toxicology, 10 (8), 1131--1143
- Protein restoration in low-birth-weight rat offspring derived from maternal low-protein diet leads to elevated hepatic CYP3A and CYP2C11 activity in adulthood (2014)
Drug Metabolism and Disposition, 42 (2), 221-228
- Down-regulation of hepatic CYP3A and CYP2C mediated metabolism in rats with moderate chronic kidney disease (2012)
Drug Metabolism and Disposition, 40 (8), 1508-1514
- In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna (2012)
Journal of Clinical Pharmacology, 52 (4), 530-542
- Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model (2012)
International Journal of Cancer, 132 (4), 967-977