Relevant Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Single-cell profiling over millions of cells (transcriptomics, epigenomics, proteomics) provides an unprecedented opportunity to dissect fundamental mechanisms of human biology and disease etiology. However, single-cell data's quality (missing values) and sample size (#subjects) pose a significant technical challenge, and state-of-the-art methodology tends to remain in a traditional biostatistical framework. As data sets are shared via a public database/repository, we have no shortage of data and computation power but suffer from the lack of creativity. Therefore, I am looking for a biology-oriented dry lab scientist willing to create and tackle high-risk, high-return projects in close collaboration with computational/statistical people. Here are potential directions, but not limited to:
- Joint analysis of single-cell measurements with bulk (tissue-level) data, such as GTEx and ENCODE projects
- Single-cell cell-cell network community detection incorporating gene-gene, protein-protein interactions
- Ascertainment of the interplay between germline and somatic mutations within cancers and across different complex disorders
- Deep learning of pleiotropic map to reveal novel contributions of cell types and states in the UK Biobank data
- Dynamic expression QTL analysis incorporating cell-cell communications in Brain and Cancer
- Single-cell dissection of polygenic risk score matrix to reveal a map of pleiotropy and polygenicity
- Identifying the effects of trans-factors (e.g., metabolic changes, hormonal perturbation, sex chromosomes) and their interplay with cis-regulatory mechanisms in complex disorders
- Strong education backgrounds in fundamental biology, genetics, and systems biology
- A proficient writer/speaker who loves to communicate with other students and collaborators
- Literacy in genomics technology and experience in a sequencing analysis pipeline
- Fluent in data analysis language, e.g., R and Python (beyond R Studio and Jupyter notebook)
- Working knowledge of a UNIX-like environment (e.g., Linux, Mac OS)
- Fluent in script languages, e.g., AWK, BASH, Makefile, Snakemake, etc.
Complete these steps before you reach out to a faculty member!
- Familiarize yourself with program requirements. You want to learn as much as possible from the information available to you before you reach out to a faculty member. Be sure to visit the graduate degree program listing and program-specific websites.
- Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. This is either indicated in the program profile under "Admission Information & Requirements" - "Prepare Application" - "Supervision" or on the program website.
- Identify specific faculty members who are conducting research in your specific area of interest.
- Establish that your research interests align with the faculty member’s research interests.
- Read up on the faculty members in the program and the research being conducted in the department.
- Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Be certain that their research is indeed what you are hoping to study.
- Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles.
- Do not send non-specific, mass emails to everyone in the department hoping for a match.
- Address the faculty members by name. Your contact should be genuine rather than generic.
- Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. The supervision enquiry form guides you with targeted questions. Ensure to craft compelling answers to these questions.
- Highlight your achievements and why you are a top student. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest.
- Demonstrate that you are familiar with their research:
- Convey the specific ways you are a good fit for the program.
- Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting.
- Be enthusiastic, but don’t overdo it.
G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application.