Alexander Weber
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Neonatal Brain Imaging
Rett Syndrome
Fractal Analysis of fMRI Signals
Cerebrovascular Health
Cerebral Metabolic Rate of Oxygen (CMRO2) Mapping by Combining Quantitative Susceptibility Mapping (QSM) and Quantitative Blood Oxygenation Level Dependent Imaging (qBOLD)
Concussions / Mild Traumatic Brain Injuries
Using Advanced MRI Techniques FLAIR2 and QSM to Identify and Classify Focal Cortical Dysplasia (FCD)
My ideal candidate is someone with experience programming (python, linux/bash, git, matlab, R), a multidisciplinary interest and background, curious, driven, humble, and good communication/interpersonal skills.
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Background: Preterm birth is associated with a higher rate of brain injury and neurodevelopmental delays in children. The brain is dependent on oxidative metabolism of glucose to meet its significant energy requirements. Understanding the cerebral metabolic rate of oxygen (CMRO₂) and how it is affected by ventilation in the neonatal population is crucial to the advancement of neonatal medicine. This study aims to assess the feasibility of quantifying CMRO₂ and cerebral blood flow (CBF) using magnetic resonance imaging (MRI) in preterm infants at term equivalent age (TEA) and to determine how various ventilatory support may affect CMRO₂. We hypothesized that increased time on mechanical ventilation would be negatively associated with CMRO2 and CBF levels in preterm neonates at TEA.Methods: Very preterm neonates (n=19) born
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Interrupted brain maturation from preterm birth increases the consequences of altered functional development (
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Publications
- Fractal-Based Analysis of fMRI BOLD Signal During Naturalistic Viewing Conditions (2022)
Frontiers in Physiology, 12 - Monofractal analysis of functional magnetic resonance imaging: An introductory review (2022)
Human Brain Mapping, 43 (8), 2693-2706 - Quantitative susceptibility mapping of venous vessels in neonates with perinatal asphyxia (2021)
American Journal of Neuroradiology, 42 (7), 1327-1333 - Myelin water imaging and R 2 * mapping in neonates: Investigating R 2 * dependence on myelin and fibre orientation in whole brain white matter (2019)
NMR in Biomedicine, 33 (3) - Quantitative Analysis of Punctate White Matter Lesions in Neonates Using Quantitative Susceptibility Mapping and R2* Relaxation. (2019)
AJNR. American journal of neuroradiology, - Pathological Insights From Quantitative Susceptibility Mapping and Diffusion Tensor Imaging in Ice Hockey Players Pre and Post-concussion. (2018)
Frontiers in neurology, - Imaging the Role of Myelin in Concussion. (2017)
Neuroimaging clinics of North America, - A preliminary study of functional connectivity of medication naïve children with obsessive-compulsive disorder. (2014)
Progress in neuro-psychopharmacology & biological psychiatry, - Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive-compulsive disorder. (2014)
Psychiatry research, - A preliminary study on the effects of acute ethanol ingestion on default mode network and temporal fractal properties of the brain. (2013)
Magma (New York, N.Y.), - Metabolite measurements in the caudate nucleus, anterior cingulate cortex and hippocampus among patients with mitochondrial disorders: a case-control study using proton magnetic resonance spectroscopy. (2013)
CMAJ open, - N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release. (2010)
Nature neuroscience, - PDLIM5 is not a neuronal CaV2.2 adaptor protein. (2009)
Nature neuroscience,
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