Anthony Traboulsee

Professor

Research Classification

Multiple Sclerosis
Imaging

Research Interests

multiple sclerosis
magnetic resonance imaging
neuromyelitls optica (NMO)

Relevant Degree Programs

 

Research Methodology

Medical physics
Computing science

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Master's students
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I support public scholarship, e.g. through the Public Scholars Initiative, and am available to supervise students and Postdocs interested in collaborating with external partners as part of their research.

Great Supervisor Week Mentions

Each year graduate students are encouraged to give kudos to their supervisors through social media and our website as part of #GreatSupervisorWeek. Below are students who mentioned this supervisor since the initiative was started in 2017.

 

I offer my heartfelt thanks to Drs. Shannon Kolind and Anthony Traboulsee, who have taught me more than I could ever have learned in a classroom. They have provided me with unconditional support and care, and encouraged critical thinking and professional growth. Even with their busy schedules, they regularly met with me to ensure that I was meeting my goals and had all necessary resources. I am very grateful for their mentorship, trust and guidance! #GreatSupervisor week at #UBC.

Lisa Eunyoung Lee (2018)

 

Graduate Student Supervision

Doctoral Student Supervision (Jan 2008 - May 2019)
Perspectives on the translational trajectory of novel biotechnologies for neurodegenerative disease (2018)

The translation of novel brain technologies from the bench to the bedside has been characterized by a tension between priorities to promote rapid access to experimental interventions and the utilitarian pursuit of their evaluation with rigorous and time-intensive research. Through three studies conducted within the scope of this dissertation, I focus on a central research question: What are the perspectives of stakeholders about the translation of novel biotechnologies for neurodegenerative disease?Harnessing the strength of pragmatic neuroethics, I address this research question using both qualitative and quantitative analyses. In the first study, I explore the perspectives of patients with multiple sclerosis (MS) about the unproven but highly publicized chronic cerebrospinal venous insufficiency (CCSVI) intervention and the impact of its controversial trajectory on stem cell research. I find that patients are disappointed about the divestment of funds from other areas of research to support CCSVI trials, but maintain enduring hopes for future neurotechnological advancements, including stem cell research. In the second study, I examine how the news media represent timeframes for research and development of stem cell interventions for MS and other neurodegenerative diseases. I find that news articles celebrate the benefits of stem cell research with little context of its caveats. In contrast to prior studies, however, I discover that they also conscientiously convey caution about stem cell tourism and describe a lengthy trajectory between research and clinical availability of therapeutics. In the third study, I explore the perspectives of patients with MS and clinicians responsible for their care about the pace of research and development for stem cell interventions. Here I describe the urgency that patients feel to access stem cell interventions and their desire to learn more about the research process. Clinicians suggest strategies for dialogue with their patients that can clarify translational timeframes and inform hopes. Overall, the findings bring together the voices of key stakeholders and support a commitment to socially minded translation of novel neurotechnologies for neurodegenerative disease.

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Master's Student Supervision (2010 - 2018)
Mechanisms of white matter in multiple sclerosis and neuromyelitis optica (2015)

Neuromyelitis optica (NMO) and multiple sclerosis (MS) both result in acute injury (i.e. attacks or relapses) to the central nervous system with focal demyelination and axonal loss that varies in severity along a spectrum. A variety of non-invasive structural imaging and functional tools can be used to investigate mechanisms of white matter injury and secondary axonal injury in MS and NMO. These include advanced magnetic resonance imaging (MRI) measures of myelin water fraction; optical coherence tomography (OCT) for retinal nerve fibre layer thickness and total macular volume; and transcranial magnetic stimulation (TMS) to determine cortical excitability and integrity of cortical spinal pathways.First, the relationship between a functional measure using TMS and a structural measure of myelin in the cortico-spinal tract was examined. Structural changes were found in the descending motor output pathway white matter in NMO along with abnormal TMS measures, suggesting that there is greater spinal cord involvement and more extensive axonal loss found in NMO compared to MS.Next, OCT was used as a measure of the anterior visual pathway and myelin water imaging of the posterior visual pathway; the effects of damage to one part of the visual system on the other was studied. Retrograde degeneration to the retina and anterograde degeneration to the optic radiations from the optic nerve was observed in both MS and NMO subjects with optic neuritis history. A correlation between the measures indicating that damage to one part may cause damage to another part of the visual pathway. Finally, damage was observed in optic pathway in MS patients without optic neuritis history suggesting that there is damage in the absence of lesions in the optic nerve.Finally, myelin water imaging was used to investigate if the disease burden of lesions regulate the level of damage to the normal appearing white matter (NAWM) tracts. The lack of correlation between disease burden of lesions and NAWM myelin water imaging in MS suggested that damage to the NAWM was mediated by processes independent of lesions.These techniques can be used to study and better understand demyelinating diseases such as MS and NMO.

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Pseudoatrophy of the brain in multiple sclerosis : the effect of therapy on T1 measures of brain water content (2010)

No abstract available.

 
 

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