Mohamed Bedaiwy


Research Classification

Research Interests

Recurrent Pregnancy Loss
Minimally Invasive Surgery

Relevant Thesis-Based Degree Programs

Affiliations to Research Centres, Institutes & Clusters



My primary focus is in exploring molecular and genetic mechanisms explaining the cause of endometriosis. Endometriosis is a disease where the lining of the uterus is implanted in the abdomen. The exact cause of this disease is unknown. We are looking into specific changes in the genome of those patients that may explain the disease. As a result, specific targeted treatment could be developed for this devastating disease.

The other focus of our research is to look into mechanisms to improve on the in vitro conditions of human embryo development. We are also looking to optimize the current techniques used for embryo freezing.

In addition, we are looking into the safety aspects of doing minimally invasive surgery using robotics.

Research Methodology

Goal 3: Good Health and Wellbeing


Master's students
Doctoral students
Postdoctoral Fellows


Recurrent Pregnancy Loss


Minimally Invasive Surgery

I am open to hosting Visiting International Research Students (non-degree, up to 12 months).
I am interested in hiring Co-op students for research placements.
I am interested in supervising students to conduct interdisciplinary research.

Complete these steps before you reach out to a faculty member!

Check requirements
  • Familiarize yourself with program requirements. You want to learn as much as possible from the information available to you before you reach out to a faculty member. Be sure to visit the graduate degree program listing and program-specific websites.
  • Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. This is either indicated in the program profile under "Admission Information & Requirements" - "Prepare Application" - "Supervision" or on the program website.
Focus your search
  • Identify specific faculty members who are conducting research in your specific area of interest.
  • Establish that your research interests align with the faculty member’s research interests.
    • Read up on the faculty members in the program and the research being conducted in the department.
    • Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Be certain that their research is indeed what you are hoping to study.
Make a good impression
  • Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles.
    • Do not send non-specific, mass emails to everyone in the department hoping for a match.
    • Address the faculty members by name. Your contact should be genuine rather than generic.
  • Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. The supervision enquiry form guides you with targeted questions. Ensure to craft compelling answers to these questions.
  • Highlight your achievements and why you are a top student. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest.
  • Demonstrate that you are familiar with their research:
    • Convey the specific ways you are a good fit for the program.
    • Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting.
  • Be enthusiastic, but don’t overdo it.
Attend an information session

G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application.



These videos contain some general advice from faculty across UBC on finding and reaching out to a potential thesis supervisor.

Great Supervisor Week Mentions

Each year graduate students are encouraged to give kudos to their supervisors through social media and our website as part of #GreatSupervisorWeek. Below are students who mentioned this supervisor since the initiative was started in 2017.


I am so grateful to have Dr.Mohamed Bedaiwy as my supervisor. He is like a candle who has lit up my career path, so I can achieve my goals. He is my role model. He appreciates me on my every little progress/achievement. He does the best he can to make learning easier for me from his own experiences as a clinician. This is my last year but I really wish if I could get this wonderful opportunity to thank him every year for all the hard work he does not only for his students but also for his patients. My success is your blessing, Dr.Bedaiwy. I would always be thankful to you.

Sunaina Sharma (2019)


Graduate Student Supervision

Doctoral Student Supervision

Dissertations completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest dissertations.

The impact of lifestyle on the reproductive, metabolic, and psychological well-being of women with polycystic ovary syndrome (PCOS) (2019)

Introduction: Polycystic ovary syndrome (PCOS) affects the reproductive, metabolic, and psychological health of 6 to 18% of women worldwide. The impact of lifestyle is poorly understood in research and practice. This dissertation aims to elucidate how dietary intake, physical activity, and psychological well-being relate to the array of symptoms and characteristics of PCOS.Methods:Women diagnosed with PCOS were compared to women without PCOS with subfertility in four observational studies. Data collected included: dietary intake, physical activity, psychological well-being symptoms (depression, anxiety, stress, and quality of life), anthropometrics, metabolic and reproductive hormonal assays. A protocol for a randomized controlled trial involving a lifestyle intervention is presented.Results:Women with PCOS had similar caloric intake and physical activity as women without PCOS, despite being more overweight (P
View record

Master's Student Supervision

Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.

Outcomes following surgical management of pelvic pain: a prospective cohort study (2020)

The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.

View record

Unexplained recurrent pregnancy loss: demographic and clinical features (2020)

Unexplained recurrent pregnancy (uRPL) loss is a devastating and challenging condition for couples as well as clinicians. One of the greatest challenges is not being able to identify the baseline etiology of recurrent pregnancy losses (RPL) when all the routine and recommended investigations return normal or negative. Pregnancy losses that are not seen on the ultrasound or are confirmed only based on decreasing urine or serum beta-hCG’s are termed as non-visualized pregnancy losses (NVPLs). Routine evaluation of NVPLs is not recommended by the American Society for Reproductive Medicine (ASRM) guidelines. The first objective of my thesis was to evaluate how different types of miscarriages affect the rates of a successful pregnancy (ongoing pregnancy at or beyond 10 weeks gestation) among the uRPL group. The three different types of miscarriages include visualized pregnancy losses (VPL), NVPL, and a combination of both (mixed). The second objective was to assess the idea of stratifying uRPL women into Type 1 (age ≥35, NVPL) and Type 2 (age
View record

Effects of gonadotropin-releasing hormone receptor antagonists on ectopic human trophoblast cell invasion (2019)

Ectopic pregnancy (EP) is a life-threatening condition responsible for 6.5% of Canadian mothers’ death between 1993-2004. EP occurs when an embryo implants outside the uterine endometrium, commonly in the Fallopian tube (98%). Tubal EP often requires surgical intervention as a life-saving measure. Early and precise diagnosis allow many women to choose methotrexate, the only available medical option, for treatment. Methotrexate is effective in 70% of patients; however, they may require multiple treatments, suffer moderate-to-severe side effects, or experience sub-optimal responses. The remaining 30% fail to respond to the treatment.Gonadotropin-releasing hormone (GnRH) has an inducing effect on intrauterine placental cell invasion and human chorionic gonadotropin hormone (hCG) production. GnRH receptor (GnRH-R) antagonists have been used safely to treat endometriosis, chronic pelvic pain, and in the artificial fertilization techniques. For the first time, we separated primary trophoblast cells from tubal EP placentas. We validated their trophoblastic origin using trophoblast-validating markers. The preliminary findings showed that primary EP trophoblast cells express GnRH and GnRH receptor. Treating these cells with clinical GnRH-R antagonist, cetrorelix, suppressed their viability. We used primary trophoblast cells from tubal pregnancies, immortalized HTR-8/SVneo cell line, and placental villous explants established from the first-trimester human intrauterine placenta in this study. We investigated the effect of clinical GnRH-R antagonists, cetrorelix and ganirelix, on the invasion of different trophoblast models. Finding a safe, effective, and more tolerant medical treatment for tubal pregnancy will significantly improve women’s health and reduce healthcare-related costs.

View record

Parity and sliding sign in endometriosis-associated pain and infertility: two cross-sectional studies (2019)

Symptomatic women with endometriosis may present with chronic pelvic pain (CPP) and infertility. Endometriosis leads to CPP through chronic inflammation, continuous peripheral nerve stimulation, and enhancement of central sensitization. The relationship between pregnancy and endometriosis is complex. Pregnancy has been proposed as a possible risk for developing CPP. However, amenorrhea has been thought to be protective against endometriosis. For fertility, endometriosis causes infertility mainly through distortion of reproductive anatomy with endometrioma and pelvic adhesions. Although endometrioma can be diagnosed with transvaginal ultrasound and sliding sign can evaluate adhesions in the posterior uterine compartment, the only way to estimate the pregnancy rate is by calculating the endometriosis fertility index (EFI). EFI calculation during laparoscopy provides a score between 0 and 10 (10 is associated with the best fertility prognosis while a score of 0 associated with the poorest fertility prognosis). In this thesis, I conducted two cross-sectional studies using a prospectively collected registry. In the first study, I compared the severity of pelvic pain between three groups of women: a group of nulligravid women (n=686), a group of parous women (n=371), and a group of women with a history of miscarriage or abortion (n=129). I found a higher number of women in the parous group had severe CPP. The nulligravid group had a higher rate of severe dysmenorrhea. Ordinal regression with backward elimination methods showed a strong association between parity and severe CPP (AOR= 1.448, 95%CI=1.092–1.918, P=0.010). In the second study, I divided infertile endometriosis patients into two groups based on the sliding sign results. The sliding sign is considered negative when the sliding motion is not observed between the colon and cervix or uterus. I found that participants with a negative sliding sign (n=26) had significantly lower total EFI scores and a lower score for each surgical factor than patients with positive sliding sign (n=60). Logistic regression showed that an EFI score of
View record

Expression of HOXB4 in Endometrial Tissues from Women with or without Endometriosis (2016)

Endometriosis is a benign gynecological disease that affects up to 10% of women of reproductive age; however, the pathogenesis of endometriosis remains poorly understood. HOX genes encode transcription factors that play roles in regulating cell proliferation, differentiation, angiogenesis, adhesion and motility in adult tissues – key features of endometriosis. The aim of this study was to examine the localization of HOXB4, via immunohistochemistry (IHC), in both eutopic (EE) and ectopic endometrial tissues (deep infiltrating endometriosis (DIE) and endometriomas (Eoma)) from women with endometriosis and compare it to endometrial tissue from women with no history of endometriosis (EC). The localization of HOXB4 in these tissues was determined via immunohistochemistry (IHC) with a monoclonal HOXB4 antibody, where immunoreactivity was assessed by Histoscore (H-Score) method. HOXB4 protein was present in the endometrial glandular epithelial cells only. HOXB4 immunoreactivity in EC was significantly higher in the proliferative phase than in the secretory phase of the menstrual cycle; however, this difference was lost among the diseased groups (EE, Eoma and DIE). Interestingly, HOXB4 expression was significantly lower in the DIE lesions compared to matched eutopic endometrium and endometrioma /DIE lesions. After normalizing HOXB4 mRNA levels to endometrial epithelial cell content, consistent with IHC results, HOXB4 mRNA levels were significantly lower in the DIE groups when compared to EC and Eoma.On the whole, HOXB4 expression is reduced in DIE, but not endometrioma, and may be dysregulated in ectopic implants. During the menstrual cycle, the expression of HOXB4 in endometrial glandular epithelial cells is higher in the proliferative phase than the secretory phase in the normal eutopic endometrium. We here report for the first time the expression of HOXB4 localization and immunoreactivity not only in the normal eutopic endometrium but also in both eutopic and ectopic endometrial tissues in women with endometriosis.

View record



If this is your researcher profile you can log in to the Faculty & Staff portal to update your details and provide recruitment preferences.


Explore our wide range of course-based and research-based program options!