Mohamed Bedaiwy

Professor

Research Classification

Research Interests

Endometriosis
Recurrent Pregnancy Loss
Infertility
Minimally Invasive Surgery

Relevant Degree Programs

Affiliations to Research Centres, Institutes & Clusters

 
 

Biography

My primary focus is in exploring molecular and genetic mechanisms explaining the cause of endometriosis. Endometriosis is a disease where the lining of the uterus is implanted in the abdomen. The exact cause of this disease is unknown. We are looking into specific changes in the genome of those patients that may explain the disease. As a result, specific targeted treatment could be developed for this devastating disease.

The other focus of our research is to look into mechanisms to improve on the in vitro conditions of human embryo development. We are also looking to optimize the current techniques used for embryo freezing.

In addition, we are looking into the safety aspects of doing minimally invasive surgery using robotics.

Research Methodology

Goal 3: Good Health and Wellbeing

Recruitment

Master's students
Doctoral students
Postdoctoral Fellows
2021

Endometriosis

Recurrent Pregnancy Loss

Infertility

Minimally Invasive Surgery

I am open to hosting Visiting International Research Students (non-degree, up to 12 months).
I am interested in hiring Co-op students for research placements.
I am interested in supervising students to conduct interdisciplinary research.

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Great Supervisor Week Mentions

Each year graduate students are encouraged to give kudos to their supervisors through social media and our website as part of #GreatSupervisorWeek. Below are students who mentioned this supervisor since the initiative was started in 2017.

 

I am so grateful to have Dr.Mohamed Bedaiwy as my supervisor. He is like a candle who has lit up my career path, so I can achieve my goals. He is my role model. He appreciates me on my every little progress/achievement. He does the best he can to make learning easier for me from his own experiences as a clinician. This is my last year but I really wish if I could get this wonderful opportunity to thank him every year for all the hard work he does not only for his students but also for his patients. My success is your blessing, Dr.Bedaiwy. I would always be thankful to you.

Sunaina Sharma (2019)

 

Graduate Student Supervision

Doctoral Student Supervision (Jan 2008 - Nov 2019)
The impact of lifestyle on the reproductive, metabolic, and psychological well-being of women with polycystic ovary syndrome (PCOS) (2019)

Introduction: Polycystic ovary syndrome (PCOS) affects the reproductive, metabolic, and psychological health of 6 to 18% of women worldwide. The impact of lifestyle is poorly understood in research and practice. This dissertation aims to elucidate how dietary intake, physical activity, and psychological well-being relate to the array of symptoms and characteristics of PCOS.Methods:Women diagnosed with PCOS were compared to women without PCOS with subfertility in four observational studies. Data collected included: dietary intake, physical activity, psychological well-being symptoms (depression, anxiety, stress, and quality of life), anthropometrics, metabolic and reproductive hormonal assays. A protocol for a randomized controlled trial involving a lifestyle intervention is presented.Results:Women with PCOS had similar caloric intake and physical activity as women without PCOS, despite being more overweight (P
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Master's Student Supervision (2010 - 2018)
Expression of HOXB4 in Endometrial Tissues from Women with or without Endometriosis (2016)

Endometriosis is a benign gynecological disease that affects up to 10% of women of reproductive age; however, the pathogenesis of endometriosis remains poorly understood. HOX genes encode transcription factors that play roles in regulating cell proliferation, differentiation, angiogenesis, adhesion and motility in adult tissues – key features of endometriosis. The aim of this study was to examine the localization of HOXB4, via immunohistochemistry (IHC), in both eutopic (EE) and ectopic endometrial tissues (deep infiltrating endometriosis (DIE) and endometriomas (Eoma)) from women with endometriosis and compare it to endometrial tissue from women with no history of endometriosis (EC). The localization of HOXB4 in these tissues was determined via immunohistochemistry (IHC) with a monoclonal HOXB4 antibody, where immunoreactivity was assessed by Histoscore (H-Score) method. HOXB4 protein was present in the endometrial glandular epithelial cells only. HOXB4 immunoreactivity in EC was significantly higher in the proliferative phase than in the secretory phase of the menstrual cycle; however, this difference was lost among the diseased groups (EE, Eoma and DIE). Interestingly, HOXB4 expression was significantly lower in the DIE lesions compared to matched eutopic endometrium and endometrioma /DIE lesions. After normalizing HOXB4 mRNA levels to endometrial epithelial cell content, consistent with IHC results, HOXB4 mRNA levels were significantly lower in the DIE groups when compared to EC and Eoma.On the whole, HOXB4 expression is reduced in DIE, but not endometrioma, and may be dysregulated in ectopic implants. During the menstrual cycle, the expression of HOXB4 in endometrial glandular epithelial cells is higher in the proliferative phase than the secretory phase in the normal eutopic endometrium. We here report for the first time the expression of HOXB4 localization and immunoreactivity not only in the normal eutopic endometrium but also in both eutopic and ectopic endometrial tissues in women with endometriosis.

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Publications

 
 

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