Anna Blakney
Assistant Professor
Research Classification
Research Interests
Gene delivery
RNA
Biomaterials
Immunoengineering
Relevant Thesis-Based Degree Programs
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
Recruitment
Master's students
Doctoral students
Postdoctoral Fellows
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Publications
- Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach (2022)
Molecular Pharmaceutics, - Voices in Molecular Pharmaceutics: Meet Dr. Anna Blakney, an Engineer Who Seeks To Develop the Next Generation of Gene Therapies (2022)
Molecular Pharmaceutics, - An Update on Self-Amplifying mRNA Vaccine Development (2021)
Vaccines, - Design-of-Experiments In Vitro Transcription Yield Optimization of Self-Amplifying RNA (2021)
- Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants (2021)
Journal of Controlled Release, 330, 1250-1261 - Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants (2021)
Biomaterials, 273, 120806 - Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice (2021)
Nature Communications, 12 (1) - Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA (2021)
Molecular Therapy, - Next-generation COVID-19 vaccines: here come the proteins (2021)
The Lancet, 397 (10275), 643-645 - Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines (2021)
Journal of Controlled Release, 338, 201-210 - Quality by design modelling to support rapid RNA vaccine production against emerging infectious diseases (2021)
npj Vaccines, 6 (1) - The next generation of RNA vaccines: self-amplifying RNA (2021)
The Biochemist, 43 (4), 14--17 - An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection (2020)
Polymer Chemistry, - Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer (2020)
ACS Nano, 14 (5), 5711--5727 - Mannosylated Poly(ethylene imine) Copolymers Enhance saRNA Uptake and Expression in Human Skin Explants (2020)
Biomacromolecules, 21 (6), 2482--2492 - Neutrophils Enable Local and Non-Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart (2020)
Advanced Materials, 32 (48) - Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA (2020)
Journal of Materials Chemistry B, - Precisely targeted gene delivery in human skin using supramolecular cationic glycopolymers (2020)
Polymer Chemistry, - Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice (2020)
Nature Communications, 11 (1) - Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients (2020)
bioRxiv, - The In Vitro, Ex Vivo, and In Vivo Effect of Polymer Hydrophobicity on Charge-Reversible Vectors for Self-Amplifying RNA (2020)
Biomacromolecules, 21 (8), 3242--3253 - Channelling the future of liposome generation (2019)
EBR - European Biopharmaceutical Review, 2019 (Janua), 66-68 - Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA (2019)
Journal of Controlled Release, 304, 65-74 - Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA (2019)
Gene Therapy, 26 (9), 363--372 - The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants (2019)
ACS Nano, 13 (5), 5920--5930 - Microbial composition predicts genital tract inflammation and persistent bacterial vaginosis in South African adolescent females (2018)
Infection and Immunity, 86 (1) - One Size Does Not Fit All: The Effect of Chain Length and Charge Density of Poly(ethylene imine) Based Copolymers on Delivery of pDNA, mRNA, and RepRNA Polyplexes (2018)
Biomacromolecules, 19 (7), 2870-2879 - Structural Components for Amplification of Positive and Negative Strand VEEV Splitzicons (2018)
Frontiers in Molecular Biosciences, 5 - Application of electrospun fibers for female reproductive health (2017)
Drug Delivery and Translational Research, 7 (6), 796-804 - In vitro-ex vivo correlations between a cell-laden hydrogel and mucosal tissue for screening composite delivery systems (2017)
Drug Delivery, 24 (1), 582-590 - Nanoparticle-releasing nanofiber composites for enhanced in vivo vaginal retention (2017)
Biomaterials, 144, 1-16 - Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants (2016)
Vaccine, 34 (32), 3702-3709 - Erratum: Corrigendum to “Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC–MS/MS assay” (Journal of Chromatography B: Analytical Technologies in the Biomedical and (2016)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1039, 88 - In pursuit of functional electrospun materials for clinical applications in humans (2016)
Therapeutic Delivery, 7 (6), 387-409 - Rapidly Biodegrading PLGA-Polyurethane Fibers for Sustained Release of Physicochemically Diverse Drugs (2016)
ACS Biomaterials Science and Engineering, 2 (9), 1595-1607 - Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay (2016)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1025, 110-118 - Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants (2015)
Vaccine, 33 (38), 4782-4789 - Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels (2015)
Biomaterials, 41, 79-88 - Interactions of Stem Cells and Components of the Extracellular Matrix (2015)
Stem Cell Nanoengineering, , 35-45 - Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics (2015)
Biomaterials, 41, 26-36 - Nanoparticle-Based ARV Drug Combinations for Synergistic Inhibition of Cell-Free and Cell-Cell HIV Transmission (2015)
Molecular Pharmaceutics, 12 (12), 4363-4374 - Reply to Thysen et al (2015)
Journal of Infectious Diseases, 212 (8), 1342-1343 - Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures (2014)
International Journal of Nanomedicine, 9 (1), 2967-2978 - Intramyocardial injection of a synthetic hydrogel with delivery of bFGF and IGF1 in a rat model of ischemic cardiomyopathy (2014)
Biomacromolecules, 15 (1), 1-11 - Electrospun fibers for vaginal anti-HIV drug delivery (2013)
Antiviral Research, 100 (SUPPL) - Understanding the host response to cell-laden poly(ethylene glycol)-based hydrogels (2013)
Biomaterials, 34 (4), 952-964 - Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to p (2012)
Journal of Biomedical Materials Research - Part A, 100 A (6), 1375-1386 - Temporal progression of the host response to implanted poly(ethylene glycol)-based hydrogels (2011)
Journal of Biomedical Materials Research - Part A, 96 A (4), 621-631
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