Abisola Kehinde
Doctor of Philosophy in Biochemistry and Molecular Biology (PhD)
Research Topic
Understanding the metabolic consequences of the systemic alanine depletion in pancreatic ductal adenocarcinoma
Seth Parker
Assistant Professor
Research Classification
Research Interests
Metabolomics
mass spectrometry
Childhood disease
Cancer
Solute carriers
Metabolism
Mitochondria
Stable-isotope tracing
Functional assay development
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Mass Spectrometry
Stable-isotope tracing
Metabolomics
Recruitment
Doctoral students
Postdoctoral Fellows
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Publications
- Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11. (2021)
Proceedings of the National Academy of Sciences of the United States of America, - Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in Ewing sarcoma. (2021)
Cancer discovery, - Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters. (2021)
Nature communications, - Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism. (2021)
Metabolites, - Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. (2020)
Nature, - Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. (2020)
Methods in molecular biology (Clifton, N.J.), - Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling. (2020)
Cancer & metabolism, - Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. (2020)
Cell reports, - Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer. (2020)
Cancer discovery, - KRAS4A directly regulates hexokinase 1. (2019)
Nature, - Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease. (2018)
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, - Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. (2017)
Cancer research, - Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics. (2016)
Molecular cell, - Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. (2016)
Cell reports, - Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016)
Nature medicine, - LKB1 promotes metabolic flexibility in response to energy stress. (2016)
Metabolic engineering, - Reductive carboxylation supports redox homeostasis during anchorage-independent growth. (2016)
Nature, - Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. (2015)
Nature communications, - Metabolic consequences of oncogenic IDH mutations. (2015)
Pharmacology & therapeutics, - IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. (2014)
Cancer research, - Regulation of substrate utilization by the mitochondrial pyruvate carrier. (2014)
Molecular cell, - Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. (2014)
Molecular cell, - Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. (2013)
Nature, - Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. (2012)
Journal of biomolecular screening, - Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). (2012)
PloS one,
Current Students & Alumni
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Membership Status
Member of G+PS
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Location
BC Children's Hospital
Program Affiliations
Department(s)
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