Seth Parker
Assistant Professor
Research Classification
Research Interests
Metabolomics
mass spectrometry
Childhood disease
Cancer
Solute carriers
Metabolism
Mitochondria
Stable-isotope tracing
Functional assay development
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Mass Spectrometry
Stable-isotope tracing
Metabolomics
Recruitment
Doctoral students
Postdoctoral Fellows
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Publications
- Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11. (2021)
Proceedings of the National Academy of Sciences of the United States of America, - Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in Ewing sarcoma. (2021)
Cancer discovery, - Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters. (2021)
Nature communications, - Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism. (2021)
Metabolites, - Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. (2020)
Nature, - Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. (2020)
Methods in molecular biology (Clifton, N.J.), - Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling. (2020)
Cancer & metabolism, - Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. (2020)
Cell reports, - Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer. (2020)
Cancer discovery, - KRAS4A directly regulates hexokinase 1. (2019)
Nature, - Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease. (2018)
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, - Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. (2017)
Cancer research, - Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics. (2016)
Molecular cell, - Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. (2016)
Cell reports, - Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016)
Nature medicine, - LKB1 promotes metabolic flexibility in response to energy stress. (2016)
Metabolic engineering, - Reductive carboxylation supports redox homeostasis during anchorage-independent growth. (2016)
Nature, - Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. (2015)
Nature communications, - Metabolic consequences of oncogenic IDH mutations. (2015)
Pharmacology & therapeutics, - IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. (2014)
Cancer research, - Regulation of substrate utilization by the mitochondrial pyruvate carrier. (2014)
Molecular cell, - Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. (2014)
Molecular cell, - Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. (2013)
Nature, - Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. (2012)
Journal of biomolecular screening, - Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). (2012)
PloS one,
Membership Status
Member of G+PS
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Location
BC Children's Hospital
Program Affiliations
Department(s)
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