Sarah Hedtrich
Associate Professor
Research Classification
Research Interests
Nanotechnology
Bioengineering Human (Disease) Models
Gene Therapy
Human Epithelia
Next-Generation Therapies for Inflammatory and Genetic Diseases of Human Epithelia
Topical drug delivery and Nanomedicine
Relevant Thesis-Based Degree Programs
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
Research Methodology
Bioengineering
Topical Drug Delivery
Complex, human-based Organ Models of Human Tissue
Preclinical Drug Development
gene editing
Recruitment
Doctoral students
Postdoctoral Fellows
Any time / year round
1. Development and characterization of complex, human-based tissue models incl. organ-on-chip cultures
2. Development of gene therapies for genetic diseases of the skin and lungs
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Publications
- A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions. (2022)
Advanced Healthcare Materials, - A similarity scaling approach for organ-on-chip devices (2022)
Lab on a Chip, - Influence of Nanogel Amphiphilicity on Dermal Delivery: Balancing Surface Hydrophobicity and Network Rigidity (2022)
Biomacromolecules, - Introducing the Molecular Pharmaceutics Special Issue on “Tiny Things, Big Impact: Nanomedicine in Canada” (2022)
Molecular Pharmaceutics, - Preclinical Testing of Dendritic Core–Multishell Nanoparticles in Inflammatory Skin Equivalents (2022)
Molecular Pharmaceutics, - Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models. (2022)
Microbiology Spectrum, - Beyond Ca2+ signalling: the role of TRPV3 in the transport of NH4+ (2021)
Pflügers Archiv - European Journal of Physiology, 473 (12), 1859--1884 - Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa. (2021)
Clinical Oral Investigations, - COVID-19 highlights the model dilemma in biomedical research (2021)
Nature Reviews Materials, - Design and Testing of Efficient Mucus‐Penetrating Nanogels—Pitfalls of Preclinical Testing and Lessons Learned (2021)
Small, , 2007963 - Gene Delivery to the Skin – How Far Have We Come? (2021)
Trends in Biotechnology, - Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications (2021)
ACS Applied Polymer Materials, - Sulfoxide-functionalized nanogels inspired by the skin penetration properties of DMSO (2021)
Biomaterials Science, - The Delivery Challenge of Genome Editing in Human Epithelia (2021)
Advanced Healthcare Materials, , 2100847 - TSLP as druggable target - a silver-lining for atopic diseases? (2021)
Pharmacology & Therapeutics, - Fibroblasts from atopic dermatitis patients trigger inflammatory processes and hyperproliferation in human skin equivalents (2020)
Journal of the European Academy of Dermatology and Venereology, 34 (6) - Impact of intercellular crosstalk between epidermal keratinocytes and dermal fibroblasts on skin homeostasis. (2020)
Biochimica et Biophysica Acta - Molecular Cell Research, - Investigation of TEMPO partitioning in different skin models as measured by EPR spectroscopy - Insight into the stratum corneum. (2020)
Journal of Magnetic Resonance, - Non-ionic PEG-oligoglycerol dendron conjugated nano-carriers for dermal drug delivery (2020)
International Journal of Pharmaceutics, 580, 119212 - Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis (2020)
Journal of Controlled Release, 318, 210--222 - Protein corona formation and its influence on biomimetic magnetite nanoparticles (2020)
Journal of Materials Chemistry B, - Critical parameters for the controlled synthesis of nanogels suitable for temperature-triggered protein delivery (2019)
Materials Science and Engineering C, 100, 141-151 - Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin (2019)
Anatomia, Histologia, Embryologia, - Insight into the redox status of inflammatory skin equivalents as determined by EPR spectroscopy (2019)
Chemico-Biological Interactions, 310 - Lyophilization of synthetic gene carriers (2019)
Methods in Molecular Biology, 1943, 211-225 - One-Pot Synthesis of Poly(glycerol-co-succinic acid) Nanogels for Dermal Delivery (2019)
Biomacromolecules, 20 (5), 1867--1875 - Quantification and characterization of radical production in human, animal and 3D skin models during sun irradiation measured by EPR spectroscopy (2019)
Free Radical Biology and Medicine, 131, 299--308 - Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming (2019)
Journal of Molecular Medicine, 97 (6), 761--775 - Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes (2019)
Planta Medica, 85 (7), 578-582 - Supramolecular nanogels fabricated via host–guest molecular recognition as penetration enhancer for dermal drug delivery (2019)
Journal of Controlled Release, 300, 64--72 - Transglutaminase 1 Replacement Therapy Successfully Mitigates the Autosomal Recessive Congenital Ichthyosis Phenotype in Full-Thickness Skin Disease Equivalents (2019)
Journal of Investigative Dermatology, 139 (5), 1191-1195 - 3D Organ Models - Revolution in Pharmacological Research? (2018)
Pharmacological Research, - Alternatives to animal testing in basic and preclinical research of atopic dermatitis (2018)
Experimental Dermatology, - Breaking the barrier - Potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels (2018)
Theranostics, 8 (2), 450-463 - Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa (2018)
Journal of Periodontal Research, 53 (1), 57-65 - Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin (2018)
Biomaterials, 162, 60-70 - Effect of Delivery Platforms Structure on the Epidermal Antigen Transport for Topical Vaccination (2018)
Biomacromolecules, 19 (12), 4607--4616 - Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels (2018)
Nanoscale, 10 (1), 469-479 - Generation of full‐thickness skin equivalents using hair follicle‐derived primary human keratinocytes and fibroblasts (2018)
Journal of Tissue Engineering and Regenerative Medicine, 12 (4), e2134--e2146 - How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis? (2018)
Journal of Investigative Dermatology, 138 (2), 455-458 - Human Pulmonary 3D Models For Translational Research (2018)
Biotechnology Journal, 13 (1) - Synthesis of poly(lactide-: Co -glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery (2018)
Nanoscale, 10 (35), 16848-16856 - Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings (2017)
Journal of Biomedical Materials Research - Part A, 105 (12), 3360-3368 - Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes (2017)
Nanotoxicology, 11 (2), 267-277 - Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles (2017)
Proceedings of the National Academy of Sciences of the United States of America, 114 (14), 3631-3636 - Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models (2017)
Skin Pharmacology and Physiology, 30 (4), 180--189 - Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium (2017)
European Journal of Pharmaceutics and Biopharmaceutics, 115, 122-130 - Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy (2017)
European Journal of Pharmaceutics and Biopharmaceutics, 118, 30-37 - NHE1 expression at wound margins increases time-dependently during physiological healing (2017)
Experimental Dermatology, 26 (2), 124-126 - One-pot and gram-scale synthesis of biodegradable polyglycerols under ambient conditions: Nanocarriers for intradermal drug delivery (2017)
Polymer Chemistry, 8 (47), 7375-7383 - pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds (2017)
Macromolecular Bioscience, 17 (5) - Protein Corona Formation on Colloidal Polymeric Nanoparticles and Polymeric Nanogels: Impact on Cellular Uptake, Toxicity, Immunogenicity, and Drug Release Properties (2017)
Biomacromolecules, 18 (6), 1762-1771 - Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery (2017)
European Journal of Pharmaceutics and Biopharmaceutics, 116, 31-37 - Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin (2017)
European Journal of Pharmaceutics and Biopharmaceutics, 116, 155-163 - Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis (2017)
Nanomedicine: Nanotechnology, Biology, and Medicine, 13 (1), 317-327 - TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents (2017)
Scientific Reports, - Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy (2016)
Journal of Controlled Release, 242, 64-70 - Development of biodegradable hyperbranched core-multishell nanocarriers for efficient topical drug delivery (2016)
Journal of Controlled Release, - Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers (2016)
Journal of Controlled Release, 242, 25-34 - Hyperbranched glycerol-based core-amphiphilic branched shell nanotransporters for dermal drug delivery (2016)
Polymer (United Kingdom), 96, 156-166 - Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and β-Defensins in Filaggrin-Deficient Skin Equivalents (2016)
Journal of Investigative Dermatology, 136 (3), 631-639 - Intradermal drug delivery by nanogel-peptide conjugates; specific and efficient transport of temoporfin (2016)
Journal of Controlled Release, 242, 35-41 - Nanogel-mediated protein replacement therapy for autosomal recessive congenital ichthyosis (ARCI) (2016)
World Congress on Recent Advances in Nanotechnology, - Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing (2016)
Journal of Controlled Release, 242, 50-63 - Feasibility study for intraepidermal delivery of proteins using a solid microneedle array (2015)
International Journal of Pharmaceutics, 486 (1-2), 52-58 - Hyaluronic acid for percutaneous drug delivery (2015)
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum, , 1-10 - Interactions of hyaluronic acid with the skin and implications for the dermal delivery of biomacromolecules (2015)
Molecular Pharmaceutics, 12 (5), 1391-1401 - Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers (2015)
Biotechnology Advances, 33 (6), 1355-1369 - Selective probing of the penetration of dexamethasone into human skin by soft X-ray spectromicroscopy (2015)
Analytical Chemistry, 87 (12), 6173-6179 - Stimulation of PPARα normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin (2015)
Journal of Dermatological Science, 80 (2), 102-110 - Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers (2015)
RSC Advances, 5 (20), 14958-14966 - The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs - A morphological study (2015)
Clinical Hemorheology and Microcirculation, 61 (2), 157-174 - Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules (2015)
Nanomedicine: Nanotechnology, Biology, and Medicine, 11 (5), 1179-1187 - Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct (2014)
Journal of Investigative Dermatology, 134 (3), 746-753 - Impact of structural differences in hyperbranched polyglycerol-polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility (2014)
European Journal of Pharmaceutics and Biopharmaceutics, 88 (3), 625-634 - Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate (2014)
Skin Pharmacology and Physiology, 27 (4), 173-180 - Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders (2014)
Experimental Dermatology, 23 (4), 286-288 - Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair (2014)
Theranostics, 4 (7), 721-735 - Penetration of normal, damaged and diseased skin - An in vitro study on dendritic core-multishell nanotransporters (2014)
Journal of Controlled Release, 185 (1), 45-50 - A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds (2013)
International Journal of Pharmaceutics, 444 (1-2), 96-102 - Comparison of four different particle sizing methods for siRNA polyplex characterization (2013)
European Journal of Pharmaceutics and Biopharmaceutics, 84 (2), 255-264 - Cytoprotective effects of opioids on irradiated oral epithelial cells (2013)
Wound Repair and Regeneration, 21 (6), 883-889 - Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes (2013)
European Journal of Pharmaceutics and Biopharmaceutics, 85 (2), 294-305 - Polyglycerol coatings of glass vials for protein resistance (2013)
European Journal of Pharmaceutics and Biopharmaceutics, 85 (3 PAR), 756-764 - Reconstructed skin models as emerging tools for drug absorption studies (2013)
Expert Opinion on Drug Metabolism and Toxicology, 9 (10), 1255-1263 - Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules (2013)
Journal of Controlled Release, 169 (3), 289-295 - Targeting inflammation and wound healing by opioids (2013)
Trends in Pharmacological Sciences, 34 (6), 303-312 - Magnetic drug targeting as new therapeutic option for the treatment of biomaterial infections (2012)
Journal of Biomaterials Science, 23 (18), 2321-2336 - Morphine metabolism in human skin microsomes (2012)
Skin Pharmacology and Physiology, 25 (6), 319-322 - Morphine stimulates cell migration of oral epithelial cells by delta-opioid receptor activation (2012)
PLoS ONE, 7 (8) - Non-analgesic effects of opioids: Peripheral opioid effects on inflammation and wound healing (2012)
Current Pharmaceutical Design, 18 (37), 6053-6069 - Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down (2011)
ATLA Alternatives to Laboratory Animals, 39 (5), 471-480 - 3D-Wound healing model: Influence of morphine and solid lipid nanoparticles (2010)
Journal of Biotechnology, 148 (1), 24-30 - SLN for topical application in skin diseases-Characterization of drug-carrier and carrier-target interactions (2010)
International Journal of Pharmaceutics, 390 (2), 225-233 - Influence of nanocarrier type and size on skin delivery of hydrophilic agents (2009)
International Journal of Pharmaceutics, 377 (1-2), 169-172 - Influences of opioids and nanoparticles on in vitro wound healing models (2009)
European Journal of Pharmaceutics and Biopharmaceutics, 73 (1), 34-42 - Nanoparticles for skin penetration enhancement - A comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles (2009)
European Journal of Pharmaceutics and Biopharmaceutics, 71 (2), 243-250
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