Elizabeth Castle
Doctor of Philosophy in Biomedical Engineering (PhD)
Research Topic
Controlling endothelial cell dynamics to direct blood cell emergence
Peter Zandstra
Professor
Research Classification
Research Interests
Stem cell bioengineering
Bioengineering
Synthetic biology
Biomedical Engineering
Immuno-engineering
Biotechnology
Computational Biology
Computational modeling
Gene/Cell Therapy Systems
genomics
Immunology
personalized medicine
Regenerative medicine
Synthetic biology
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Biotechnology
Bioengineering
Computational Biology
Recruitment
Doctoral students
Postdoctoral Fellows
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ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
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Supervision Enquiry
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Graduate Student Supervision
Master's Student Supervision
Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
Engineering human developmental organoids to model robust symmetry breaking during gastrulation (2022)
The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.
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Publications
- Sex biased human thymic architecture guides T cell development through spatially defined niches (2023)
- Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency (2022)
Proceedings of the National Academy of Sciences, - IQCELL: A platform for predicting the effect of gene perturbations on developmental trajectories using single-cell RNA-seq data (2022)
PLOS Computational Biology, 18 (2), e1009907 - Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development (2022)
npj Regenerative Medicine, - Symmetry-breaking in adherent pluripotent stem cell-derived developmental patterns (2022)
- Discrete-to-analog signal conversion in human pluripotent stem cells (2021)
- Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner (2021)
- Gene regulatory network (GRN) embedded agents connect cellular decision making to human pluripotent stem cell derived germ layer-like pattern formation (2020)
- Nicotinamide promotes differentiation of pancreatic endocrine progenitors from human pluripotent stem cells through poly (ADP-ribose) polymerase inhibition (2020)
- Chemically controlled aggregation of pluripotent stem cells (2018)
Biotechnology and Bioengineering, 115 (8), 2061--2066 - Modeling signaling‐dependent pluripotency with Boolean logic to predict cell fate transitions (2018)
Molecular Systems Biology, 14 (1) - A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning (2017)
Development, 144 (23), 4298--4312
Current Students & Alumni
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