Elizabeth Castle
Doctor of Philosophy in Biomedical Engineering (PhD)
Research Topic
Controlling endothelial cell dynamics to direct blood cell emergence
Peter Zandstra
Professor
Research Classification
Research Interests
Stem cell bioengineering
Bioengineering
Synthetic biology
Biomedical Engineering
Immuno-engineering
Biotechnology
Computational Biology
Computational modeling
Gene/Cell Therapy Systems
genomics
Immunology
personalized medicine
Regenerative medicine
Synthetic biology
Relevant Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Research Methodology
Biotechnology
Bioengineering
Computational Biology
Recruitment
Doctoral students
Postdoctoral Fellows
2021
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Publications
- IQCELL: A platform for predicting the effect of gene perturbations on developmental trajectories using single-cell RNA-seq data (2022)
PLOS Computational Biology, 18 (2), e1009907 - Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development (2022)
npj Regenerative Medicine, - Discrete-to-analog signal conversion in human pluripotent stem cells (2021)
- Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner (2021)
- Gene regulatory network (GRN) embedded agents connect cellular decision making to human pluripotent stem cell derived germ layer-like pattern formation (2020)
- Nicotinamide promotes differentiation of pancreatic endocrine progenitors from human pluripotent stem cells through poly (ADP-ribose) polymerase inhibition (2020)
- Chemically controlled aggregation of pluripotent stem cells (2018)
Biotechnology and Bioengineering, 115 (8), 2061--2066 - Modeling signaling‐dependent pluripotency with Boolean logic to predict cell fate transitions (2018)
Molecular Systems Biology, 14 (1) - A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning (2017)
Development, 144 (23), 4298--4312
Current Students & Alumni
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