Manish Sadarangani
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Biography
Dr. Sadarangani is head of the Vaccine Evaluation Center (VEC) at BC Children’s Hospital. Founded in 1988, the VEC is an academic centre of excellence focusing on vaccine and immunization research in BC and across Canada. He is also a pediatric infectious disease specialist and an investigator at BC Children’s, and assistant professor with the UBC Department of Pediatrics.
The aim of his research at the Vaccine Evaluation Center (VEC) is to lower the burden of childhood infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. Hisresearch program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.
Research Methodology
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My research covers several independent, but related, areas of infectious diseases and vaccine research, including:
- Understanding vaccine-induced immunity, particular for bacterial vaccines including vaccines against Neisseria meningitidis, Streptococcus pneumoniae and Bordetella pertussis.
- Development of novel vaccines for pathogens of major public health importance.
- Infectious diseases epidemiology and evaluation of vaccine impact, with a particular interest in brain infections.
- Immunization in pregnancy.
I am Director of the Vaccine Evaluation Center (VEC) at BC Children’s Hospital Reserarch Institute. Founded in 1988, the VEC is an academic centre of excellence focusing on vaccine and immunization research in BC and across Canada. I am also a pediatric infectious disease specialist based at BC Children’s Hospital.
The aim of my research at the VEC is to lower the burden of infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. My research program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.
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Supervision Enquiry
Recent Tri-Agency Grants
The following is a selection of grants for which the faculty member was principal investigator or co-investigator. Currently, the list only covers Canadian Tri-Agency grants from years 2013/14-2016/17 and excludes grants from any other agencies.
- Determination of Burden of Invasive Haemophilus Influenzae Type A (Hia) Disease in Indigenous Communities and Study of their Knowledge, Attitudes, Beliefs, and Behaviours about Hia Disease, Vaccine, and Clinical Trials via a Community Engag - Canadian Institutes of Health Research (CIHR) - Randomized Controlled Trial Involving Influenza (2016/2017)
Publications
- The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation (2021)
mSphere, - Association between human papillomavirus vaccine status and sexually transmitted infection outcomes among females aged 18-35 with a history of sexual activity in the United States: A population survey-based cross-sectional analysis (2020)
Vaccine, 38 (52), 8396--8404 - Canadian surveillance of COVID-19 in pregnancy: Epidemiology and maternal and infant outcomes (2020)
American journal of obstetrics and gynecology, - Cervical Intraepithelial Neoplasia Rates in British Columbia Women: A Population-Level Data Linkage Evaluation of the School-Based HPV Immunization Program. (2020)
The Journal of infectious diseases, - Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic. (2020)
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, - Environmental scan of provincial and territorial planning for COVID-19 vaccination programs (2020)
- Epidemiology of Burkholderia Infections in People with Cystic Fibrosis in Canada between 2000 and 2017. (2020)
Annals of the American Thoracic Society, - Estimated susceptibility of Canadian meningococcal B isolates to a meningococcal serogroup B vaccine (MenB-FHbp) (2020)
Vaccine, 38 (8), 2026--2033 - Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine. (2020)
Molecular systems biology, - Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial. (2020)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, - Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome? (2020)
Trends in immunology, - Incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate pneumococcal vaccine in British Columbia: A retrospective cohort study (2020)
PLOS ONE, 15 (9), e0239848 - Maternal Immunological Adaptation During Normal Pregnancy (2020)
Frontiers in Immunology, 11 - Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory (2020)
Journal of Medical Microbiology, - Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort. (2020)
Frontiers in immunology, - Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study. (2020)
PloS one, - Pertussis vaccination in pregnancy in Canada: a cost-utility analysis. (2020)
CMAJ open, - Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution – Insights into a novel experimental and analytical approach (2020)
Vaccine, 38 (34), 5389--5392 - Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success. (2020)
BMC pediatrics, - Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults. (2020)
Frontiers in immunology, - Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant. (2020)
JAMA pediatrics, - What is the role of SARS-CoV-2 PCR testing in discontinuation of transmission-based precautions for COVID-19 patients? (2020)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, - 41 Lessons learned during the practice of a no-conflict of-interest panel-of-three adjudication process in the RSV program. (2019)
Paediatrics & Child Health, - 42 A risk factor approach is highly effective at selecting 29-34w gestation infants at risk for first season RSV-related admissions – a population study. (2019)
Paediatrics & Child Health, - A Population-based Observational Study of Childhood Encephalitis in Children Admitted to Pediatric Intensive Care Units in England and Wales. (2019)
The Pediatric infectious disease journal, - Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component. (2019)
Scientific reports, - Dilemmas With Rotavirus Vaccine: The Neonate and Immunocompromised. (2019)
The Pediatric infectious disease journal, - Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns. (2019)
Archives of disease in childhood. Education and practice edition, - From mother to baby: antenatal exposure to monoclonal antibody biologics. (2019)
Expert review of clinical immunology, - Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females? - A systematic review. (2019)
Vaccine, - Meningitis vaccines in children: what have we achieved and where next? (2019)
Current opinion in infectious diseases, - Outcomes beyond hospital discharge in infants and children with viral meningitis: A systematic review. (2019)
Reviews in medical virology, - Recurrent immune thrombocytopenia following different vaccines. (2019)
BMJ case reports, - Separating myths from reality for vaccines causing adverse events following immunization: An interview with Manish Sadarangani (2019)
Future Microbiology, 14 (11), 925-926 - Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection (2019)
- The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies. (2019)
Frontiers in immunology, - The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana. (2019)
BMC pediatrics, - To LP or not to LP? Identifying the Etiology of Pediatric Meningitis. (2019)
The Pediatric infectious disease journal, - Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study. (2019)
PloS one, - 153. The Effect of Timing of Tetanus–Diphtheria and Pertussis Vaccine Administration in Pregnancy on The Avidity of Pertussis Antibodies. (2018)
Open forum infectious diseases, - 2466. Evaluation of Immunization on the Neonatal Intensive Care Unit at British Columbia Women’s Hospital. (2018)
Open forum infectious diseases, - Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015. (2018)
Journal of the Pediatric Infectious Diseases Society, - Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias. (2018)
PloS one, - Effect of human papillomavirus vaccination on sexual behaviour among young females. (2018)
Canadian family physician Medecin de famille canadien, 64 (7), 509-513 - Immunization in Pregnancy: The Future for Neonatal Protection. (2018)
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, - L'immunisation pendant la grossesse : l'avenir de la protection néonatale. (2018)
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, - Management of suspected paediatric meningitis: a multicentre prospective cohort study. (2018)
Archives of disease in childhood, - Meningococcal vaccination in pregnancy. (2018)
Human vaccines & immunotherapeutics, - Protection Against Invasive Infections in Children Caused by Encapsulated Bacteria. (2018)
Frontiers in immunology, - Strategies to improve detection and management of human parechovirus infection in young infants. (2018)
The Lancet. Infectious diseases, - 30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study (2017)
The Lancet Infectious Diseases, 17 (4), 422--430 - 30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study. (2017)
The Lancet. Infectious diseases, - A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology. (2017)
PloS one, - Age-specific trends in antibiotic resistance in Escherichia coli infections in Oxford, United Kingdom 2013–2014 (2017)
Journal of Infection, 74 (2), 195--198 - Care beyond the hospital ward: understanding the socio-medical trajectory of herpes simplex virus encephalitis. (2017)
BMC health services research, - Four Component Meningococcal Capsular Group B Vaccine in Preterm Infants (2017)
Journal of the Pediatric Infectious Diseases Society, 6 (3), 309--310 - Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis (2017)
The Lancet Infectious Diseases, 17 (7), e223--e234 - Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis. (2017)
The Lancet. Infectious diseases, - Immunizing Patients with Adverse Events Following Immunization in the Canadian Special Immunization Clinic Network (2015–2017) (2017)
Open Forum Infectious Diseases, 4 (Array), S515--S516 - Maternal immunisation: collaborating with mother nature (2017)
The Lancet Infectious Diseases, 17 (7), e197--e208 - Maternal immunisation: collaborating with mother nature. (2017)
The Lancet. Infectious diseases, - Meningococcal Vaccines (2017)
Pediatric Vaccines and Vaccinations, , 215--224 - Persistence of immunity after vaccination with a capsular group B meningococcal vaccine in 3 different toddler schedules (2017)
Canadian Medical Association Journal, 189 (41), E1276--E1285 - Pneumocystis jirovecii Pneumonia in Pediatric Inflammatory Bowel Disease: A Case Report and Literature Review (2017)
Frontiers in Pediatrics, - Prevalence and decay of maternal pneumococcal and meningococcal antibodies: A meta-analysis of type-specific decay rates (2017)
Vaccine, 35 (43), 5850--5857 - The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses (2017)
JAMA Pediatrics, 171 (7), 637 - Whither vaccines? (2017)
The Journal of infection, - Whither vaccines? (2017)
Journal of Infection, 74, S2--S9 - A humanized microbiota mouse model of ovalbumin-induced lung inflammation (2016)
Gut Microbes, 7 (4), 342--352 - Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection (2016)
The Pediatric Infectious Disease Journal, 35 (3), 347--349 - Can we control all-cause meningococcal disease in Europe? (2016)
Clinical Microbiology and Infection, 22, S103--S112 - Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells (2016)
PLOS ONE, 11 (4), e0154153 - Clinical aspects of meningococcal disease (2016)
Handbook of Meningococcal Disease Management, , 57--73 - Gene expression profiles are different in venous and capillary blood: Implications for vaccine studies (2016)
Vaccine, 34 (44), 5306--5313 - Handbook of Meningococcal Disease Management (2016)
Springer International Publishing , - Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study (2016)
The Lancet Infectious Diseases, 16 (11), 1279--1287 - Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study. (2016)
The Lancet. Infectious diseases, - ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial (2016)
BMJ Open, 6 (11) - Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles (2016)
PLOS ONE, 11 (2), e0148840 - Meningitis (2016)
Manual of Childhood Infections (4th edition) , - Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation (2016)
Journal of Biosciences, 41 (1), 13--19 - Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI): an extension of the STROBE statement for neonatal infection research (2016)
The Lancet Infectious Diseases, 16 (10), e202--e213 - Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI): an extension of the STROBE statement for neonatal infection research. (2016)
The Lancet. Infectious Diseases, - Symptomatic stroke complicating central skull base osteomyelitis following otitis media in a 2-year old boy: Case report and review of the literature (2016)
International Journal of Pediatric Otorhinolaryngology, 89, 140--144 - The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials (2016)
Vaccine, 34 (34), 3986--3992 - Unusual case of lymphangitis in a 2-year-old boy (2016)
BMJ Case Reports, , bcr2016215058 - Use of rotavirus vaccines in preterm babies on the neonatal unit (2016)
Expert Review of Vaccines, 15 (12), 1463--1465 - A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial (2015)
Journal of Infection, 71 (3), 326--337 - Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia (2015)
Journal of Pediatric Hematology/Oncology, 37 (6), e384--e386 - Meningococcus (2015)
Nelson Textbook of Pediatrics (20th edition) , - Outcomes of Invasive Meningococcal Disease in Adults and Children in Canada Between 2002 and 2011: A Prospective Cohort Study (2015)
Clinical Infectious Diseases, 60 (8), e27--e35 - Response to Hepatitis B virus vaccine in young adults with perinatally acquired HIV infection (2015)
Journal of Infection, 71 (4), 495--497 - Subacute Osteomyelitis of the Femur Due to Fusobacterium nucleatum in a 7-year-old Boy (2015)
The Pediatric Infectious Disease Journal, 34 (3), 324--326 - Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice (2014)
PLoS ONE, 9 (12), e115713 - Association between population prevalence of smoking and incidence of meningococcal disease in Norway, Sweden, Denmark and the Netherlands between 1975 and 2009: a population-based time series analysis (2014)
BMJ Open, 4 (2), e003312 - Childhood meningitis in the conjugate vaccine era: a prospective cohort study (2014)
Archives of Disease in Childhood, 100 (3), 292--294 - Erratum: The role of the immune system in governing host-microbe interactions in the intestine (Nature Immunology (2013) 14 (660-667)) (2014)
Nature Immunology, 15 (2), 205 - Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study (2014)
The Lancet Infectious Diseases, 14 (5), 397--405 - Long-Term Survival and Outcome in Children Admitted to Kilifi District Hospital with Convulsive Status Epilepticus (2014)
Epilepsy Research and Treatment, 2014, 1--7 - The capsular group B meningococcal vaccine, 4CMenB: clinical experience and potential efficacy (2014)
Expert Opinion on Biological Therapy, 15 (1), 131--142 - The Impact of the Meningococcal Serogroup C Conjugate Vaccine in Canada Between 2002 and 2012 (2014)
Clinical Infectious Diseases, 59 (9), 1208-1215 - Adolescents need a booster of serogroup C meningococcal vaccine to protect them and maintain population control of the disease (2013)
Archives of Disease in Childhood, 98 (4), 248--251 - Correction: Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine. (2013)
PloS one, - How best to describe the risk of meningococcal B infection? (2013)
Paediatrics & Child Health, 18 (10), 543--544 - Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens (2013)
Clinical and Vaccine Immunology, 21 (2), 234--242 - Neonatal Sepsis due to Coagulase-Negative Staphylococci (2013)
Clinical and Developmental Immunology, 2013, 1--10 - The role of the immune system in governing host-microbe interactions in the intestine (2013)
Nature Immunology, 14 (7), 660--667 - Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine (2012)
PLoS ONE, 7 (12), e51045 - Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast (2011)
Brain, 134 (5), 1519--1528 - Bacterial Meningitis in Childhood (2011)
Hot Topics in Infection and Immunity in Children VIII, , 185--199 - Opa proteins and CEACAMs: pathways of immune engagement for pathogenicNeisseria (2011)
FEMS Microbiology Reviews, 35 (3), 498--514 - Potential of Recombinant Opa Proteins as Vaccine Candidates against Hyperinvasive Meningococci (2011)
Infection and Immunity, 79 (7), 2810--2818 - Serogroup B meningococcal vaccines—an unfinished story (2010)
The Lancet Infectious Diseases, 10 (2), 112--124 - An observational study of children with sickle cell disease in Kilifi, Kenya (2009)
British Journal of Haematology, 146 (6), 675--682 - Challenges and progress in the development of a serogroup B meningococcal vaccine (2009)
Expert Review of Vaccines, 8 (6), 729--745 - Malaria as a Cause of Morbidity and Mortality in Children with Homozygous Sickle Cell Disease on the Coast of Kenya (2009)
Clinical Infectious Diseases, 49 (2), 216--222 - Role of Acquired Immunity in Neisseria Infections (2009)
Neisseria: Molecular Mechanisms of Pathogenesis, - Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study (2008)
The Lancet Neurology, 7 (2), 145--150 - An analysis of herpes simplex virus gene expression during latency establishment and reactivation. (1999)
Journal of General Virology, 80 (5), 1271--1282
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