Manish Sadarangani

Assistant Professor

Research Classification

Microbiology
Bacteria
Immune System
Epidemiology
Vaccine Development

Research Interests

Bacterial Vaccines
Vaccine immunity
Epidemiology
Childhood infections

Relevant Degree Programs

 
 

Biography

Dr. Sadarangani is head of the Vaccine Evaluation Center (VEC) at BC Children’s Hospital. Founded in 1988, the VEC is an academic centre of excellence focusing on vaccine and immunization research in BC and across Canada. He is also a pediatric infectious disease specialist and an investigator at BC Children’s, and assistant professor with the UBC Department of Pediatrics.

The aim of his research at the Vaccine Evaluation Center (VEC) is to lower the burden of childhood infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. Hisresearch program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.

Research Methodology

In vitro immune responses to vaccines
Population level evaluation of immunization programs
Animal models for immunization
Bacterial modification

Recruitment

Master's students
Doctoral students
Postdoctoral Fellows
Any time / year round

My research covers several independent, but related, areas of infectious diseases and vaccine research, including:

- Understanding vaccine-induced immunity, particular for bacterial vaccines including vaccines against Neisseria meningitidis, Streptococcus pneumoniae and Bordetella pertussis.

- Development of novel vaccines for pathogens of major public health importance.

- Infectious diseases epidemiology and evaluation of vaccine impact, with a particular interest in brain infections.

- Immunization in pregnancy.

I am Director of the Vaccine Evaluation Center (VEC) at BC Children’s Hospital Reserarch Institute. Founded in 1988, the VEC is an academic centre of excellence focusing on vaccine and immunization research in BC and across Canada. I am also a pediatric infectious disease specialist based at BC Children’s Hospital.

The aim of my research at the VEC is to lower the burden of infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. My research program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.

I support public scholarship, e.g. through the Public Scholars Initiative, and am available to supervise students and Postdocs interested in collaborating with external partners as part of their research.
I support experiential learning experiences, such as internships and work placements, for my graduate students and Postdocs.
I am open to hosting Visiting International Research Students (non-degree, up to 12 months).
I am interested in hiring Co-op students for research placements.

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Recent Tri-Agency Grants

The following is a selection of grants for which the faculty member was principal investigator or co-investigator. Currently, the list only covers Canadian Tri-Agency grants from years 2013/14-2016/17 and excludes grants from any other agencies.

  • Determination of Burden of Invasive Haemophilus Influenzae Type A (Hia) Disease in Indigenous Communities and Study of their Knowledge, Attitudes, Beliefs, and Behaviours about Hia Disease, Vaccine, and Clinical Trials via a Community Engag - Canadian Institutes of Health Research (CIHR) - Randomized Controlled Trial Involving Influenza (2016/2017)

Publications

 
 

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