Relevant Degree Programs
Francis Lynn completed his PhD in Ray Pederson's laboratory at UBC where he became interested in beta cells, diabetes and gene regulation. Postdoctoral studies with Michael German in San Francisco piqued his interest in beta cell development and small RNA biology.
His group is interested in understanding the mechanisms that regulate the formation of islet β-cells from pancreatic stem or progenitor cells during solid organ formation. They focus on the gene regulatory networks at play in the progenitor cells and how these networks change during differentiation to mature endocrine cells and in the long-term maintenance of the β-cell. They believe that a greater understanding of these genetic mechanisms and pathways will refine cell-based approaches for preventing and reversing the β-cell deterioration and loss that occur with diabetes.
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Research in the Lynn lab is targeted at understanding the insulin-producing pancreatic β-cell, how it fails during diabetes mellitus and how we can make surrogate cells to cure diabetes. We use a variety of models to study the regulatory pathways important for embryonic β-cell genesis and function.
The current focus of research in the lab is understanding how DNA-binding transcription factors regulate β-cell formation and function, how they are reguated post-translationally and how they prevent β-cell dysfunction and diabetes.
We currently have positions available for graduate students and postdoctoral scholars interested in studying the regulation of pancreatic β-cell development and function. Please contact me personally by e-mail with a cover letter outlining your interests, why you would like to join my lab, and please include your vita. Experience in cell and developmental biology, molecular biology or stem cell biology is preferred. More important are curiosity and passion about stem and developmental biology, and a talent for independent research, supported by a strong publication record.
Graduate Student Supervision
Doctoral Student Supervision (2008-2017)
- The cell cycle regulates mouse and human pancreas development (2018)
- The roles of SOX4 and MED15 in the development and maintenance of pancreatic β-cells (2017)
- The role of NPAS4 in glucose homeostasis (2016)
- Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells. (2018)
Sabatini PV and Speckmann T and Nian C and Glavas MM and Wong CK and Yoon JS and Kin T and Shapiro AMJ and Gibson WT and Verchere CB and Lynn FC
- SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a (2017)
Eric E. Xu and Shugo Sasaki and Thilo Speckmann and Cuilan Nian and Francis C. Lynn
Diabetes 66 (8) 2213--2219
- Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors (2017)
Nicole A.J. Krentz and Dennis van Hoof and Zhongmei Li and Akie Watanabe and Mei Tang and Cuilan Nian and Michael S. German and Francis C. Lynn
Developmental Cell 41 (2) 129--142.e6
- The p300 and CBP Transcriptional Coactivators are Required for Beta Cell and Alpha Cell Proliferation (2017)
Chi Kin Wong and Adam K Wade-Vallance and Dan S Luciani and Paul K Brindle and Francis C Lynn and William T Gibson
- Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8) (2016)
Miriam Ejarque and Joan Mir-Coll and Ramon Gomis and Michael S. German and Francis C. Lynn and Rosa Gasa
PLOS ONE 11 (1) e0146273
- Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. (2016)
Speckmann T and Sabatini PV and Nian C and Smith RG and Lynn FC
The Journal of biological chemistry
- Reawakening the Duct Cell Progenitor? (2016)
C. Bruce Verchere and Francis C. Lynn
Endocrinology 157 (1) 52--53
- Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. (2016)
Szabat M and Page MM and Panzhinskiy E and Skovsø S and Mojibian M and Fernandez-Tajes J and Bruin JE and Bround MJ and Lee JT and Xu EE and Taghizadeh F and O'Dwyer S and Johnson JD
- Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellitus (2016)
Nicole A. J. Krentz and Francis C. Lynn
Genome Editing 127--147
- All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes (2015)
Paul V. Sabatini and Francis C. Lynn
Trends in Endocrinology & Metabolism 26 (1) 49--57
- SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. (2015)
Xu EE and Krentz NA and Tan S and Chow SZ and Tang M and Nian C and Lynn FC
- Use-dependent activation of neuronal Kv1.2 channel complexes. (2015)
Baronas VA and McGuinness BR and Brigidi GS and Gomm Kolisko RN and Vilin YY and Kim RY and Lynn FC and Bamji SX and Yang R and Kurata HT
The Journal of neuroscience : the official journal of the Society for Neuroscience
- Glycoprotein 130 Receptor Signaling Mediates alpha-Cell Dysfunction in a Rodent Model of Type 2 Diabetes (2014)
S. Z. Chow and M. Speck and P. Yoganathan and D. Nackiewicz and A. M. Hansen and M. Ladefoged and B. Rabe and S. Rose-John and P. J. Voshol and F. C. Lynn and P. L. Herrera and W. Muller and H. Ellingsgaard and J. A. Ehses
Diabetes 63 (9) 2984--2995
- Quetiapine treatment in youth is associated with decreased insulin secretion. (2014)
Ngai YF and Sabatini P and Nguyen D and Davidson J and Chanoine JP and Devlin AM and Lynn FC and Panagiotopoulos C
Journal of clinical psychopharmacology
- TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. (2014)
Krentz NA and Nian C and Lynn FC
- Identification and analysis of murine pancreatic islet enhancers. (2013)
Tennant BR and Robertson AG and Kramer M and Li L and Zhang X and Beach M and Thiessen N and Chiu R and Mungall K and Whiting CJ and Sabatini PV and Kim A and Gottardo R and Marra MA and Hoffman BG
- Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells (2013)
Paul V. Sabatini and Nicole A.J. Krentz and Bader Zarrouki and Clara Y. Westwell-Roper and Cuilan Nian and Ryan A. Uy and A.M. James Shapiro and Vincent Poitout and Francis C. Lynn
Diabetes 62 (8) 2808--2820
- The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. (2013)
Rawnsley DR and Xiao J and Lee JS and Liu X and Mericko-Ishizuka P and Kumar V and He J and Basu A and Lu M and Lynn FC and Pack M and Gasa R and Kahn ML
The Journal of biological chemistry
- Maintenance of beta-Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology (2012)
M. Szabat and F. C. Lynn and B. G. Hoffman and T. J. Kieffer and D. W. Allan and J. D. Johnson
Diabetes 61 (6) 1365--1371
- Noncoding RNAs (2012)
Anandwardhan A. Hardikar and Michael D. Walker and Francis Lynn
Experimental Diabetes Research 2012 1--2
- Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization (2012)
Gina M. Whitaker and Francis C. Lynn and Christopher H. S. McIntosh and Eric A. Accili
PLoS ONE 7 (3) e32675
- A mouse model for monitoring islet cell genesis and developing therapies for diabetes. (2011)
Shimajiri Y and Kosaka Y and Scheel DW and Lynn FC and Kishimoto N and Wang J and Zhao S and German MS
Disease models & mechanisms
- Sequence and epigenetic determinants in the regulation of the Math6 gene by Neurogenin3. (2011)
Pujadas G and Felipe F and Ejarque M and Sanchez L and Cervantes S and Lynn FC and Gomis R and Gasa R
Differentiation; research in biological diversity
- Rfx6 directs islet formation and insulin production in mice and humans. (2010)
Smith SB and Qu HQ and Taleb N and Kishimoto NY and Scheel DW and Lu Y and Patch AM and Grabs R and Wang J and Lynn FC and Miyatsuka T and Mitchell J and Seerke R and Désir J and German MS
- Serotonin regulates pancreatic beta cell mass during pregnancy (2010)
Hail Kim and Yukiko Toyofuku and Francis C Lynn and Eric Chak and Toyoyoshi Uchida and Hiroki Mizukami and Yoshio Fujitani and Ryuzo Kawamori and Takeshi Miyatsuka and Yasuhiro Kosaka and Katherine Yang and Gerard Honig and Marieke van der Hart and Nina Kishimoto and Juehu Wang and Soroku Yagihashi and Laurence H Tecott and Hirotaka Watada and Michael S German
Nature Medicine 16 (7) 804--808
- Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. (2009)
Wang YC and Gallego-Arteche E and Iezza G and Yuan X and Matli MR and Choo SP and Zuraek MB and Gogia R and Lynn FC and German MS and Bergsland EK and Donner DB and Warren RS and Nakakura EK
- Meta-regulation: microRNA regulation of glucose and lipid metabolism (2009)
Francis C. Lynn
Trends in Endocrinology & Metabolism 20 (9) 452--459
- Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. (2008)
Lynn FC and Sanchez L and Gomis R and German MS and Gasa R
- Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade. (2008)
Gasa R and Mrejen C and Lynn FC and Skewes-Cox P and Sanchez L and Yang KY and Lin CH and Gomis R and German MS
Differentiation; research in biological diversity
- Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. (2008)
Reid JG and Nagaraja AK and Lynn FC and Drabek RB and Muzny DM and Shaw CA and Weiss MK and Naghavi AO and Khan M and Zhu H and Tennakoon J and Gunaratne GH and Corry DB and Miller J and Gunaratne PH
- Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. (2008)
Kodra JT and Jørgensen AS and Andersen B and Behrens C and Brand CL and Christensen IT and Guldbrandt M and Jeppesen CB and Knudsen LB and Madsen P and Nishimura E and Sams C and Lau J
Journal of medicinal chemistry
- MicroRNA expression is required for pancreatic islet cell genesis in the mouse. (2007)
Lynn FC and Skewes-Cox P and Kosaka Y and McManus MT and Harfe BD and German MS
- Post-translational regulation of the beta-cell specific factor Nkx6.1 (2007)
Anastasia Mavropoulos and Francis C. Lynn and Skewes-Cox Peter and Michael T. MacManus and Michael S. German
Developmental Biology 306 (1) 365
- Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat. (2007)
Piteau S and Olver A and Kim SJ and Winter K and Pospisilik JA and Lynn F and Manhart S and Demuth HU and Speck M and Pederson RA and McIntosh CH
Biochemical and biophysical research communications
- Sox9 coordinates a transcriptional network in pancreatic progenitor cells. (2007)
Lynn FC and Smith SB and Wilson ME and Yang KY and Nekrep N and German MS
Proceedings of the National Academy of Sciences of the United States of America
- The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. (2005)
Wilson ME and Yang KY and Kalousova A and Lau J and Kosaka Y and Lynn FC and Wang J and Mrejen C and Episkopou V and Clevers HC and German MS
- A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. (2003)
Lynn FC and Thompson SA and Pospisilik JA and Ehses JA and Hinke SA and Pamir N and McIntosh CH and Pederson RA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates beta-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats (2003)
J. A. Pospisilik and J. Martin and T. Doty and J. A. Ehses and N. Pamir and F. C. Lynn and S. Piteau and H.-U. Demuth and C. H.S. McIntosh and R. A. Pederson
Diabetes 52 (3) 741--750
- Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential. (2003)
Hinke SA and Lynn F and Ehses J and Pamir N and Manhart S and Kühn-Wache K and Rosche F and Demuth HU and Pederson RA and McIntosh CH
Advances in experimental medicine and biology
- Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. (2003)
Pamir N and Lynn FC and Buchan AM and Ehses J and Hinke SA and Pospisilik JA and Miyawaki K and Yamada Y and Seino Y and McIntosh CH and Pederson RA
American journal of physiology. Endocrinology and metabolism
- Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP). (2003)
Hinke SA and Gelling R and Manhart S and Lynn F and Pederson RA and Kühn-Wache K and Rosche F and Demuth HU and Coy D and McIntosh CH
- Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. (2001)
Lynn FC and Pamir N and Ng EH and McIntosh CH and Kieffer TJ and Pederson RA
- Characterization of the Carboxyl-terminal Domain of the Rat Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor (1999)
Michael B. Wheeler and Richard W. Gelling and Simon A. Hinke and Ba Tu and Raymond A. Pederson and Francis Lynn and Jan Ehses and Christopher H. S. McIntosh
Journal of Biological Chemistry 274 (35) 24593--24601
- Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. (1999)
McIntosh CH and Bremsak I and Lynn FC and Gill R and Hinke SA and Gelling R and Nian C and McKnight G and Jaspers S and Pederson RA
- Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide (1999)
Robert P. Pauly and Hans-Ulrich Demuth and Fred Rosche and JÃ¶rn Schmidt and Heather A. White and Francis Lynn and Christopher H.S. McIntosh and Raymond A. Pederson
Metabolism 48 (3) 385--389
- HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. (1997)
Kalchman MA and Koide HB and McCutcheon K and Graham RK and Nichol K and Nishiyama K and Kazemi-Esfarjani P and Lynn FC and Wellington C and Metzler M and Goldberg YP and Kanazawa I and Hayden MR