Ramon Klein Geltink
Relevant Thesis-Based Degree Programs
My research program at UBC/BCCHRI aims to better understand how the immune system can be used to treat childhood diseases. In children with cancer, the immune system is no longer able to rid the body of cancerous cells. In children with autoimmune diseases the immune system gets rid of healthy cells of the body. We are particularly interested in the metabolism of immune cells.
Cellular metabolism consists of a complex network of biochemical pathways crucial for energy homeostasis and the generation of biomass to facilitate cell proliferation. In rapidly dividing T cells this is especially demanding, and often associated with ‘Warburg metabolism” or aerobic glycolysis. Regulation of CD8+ T cell fate and function is strongly linked to differences in metabolic reprogramming. The flexibility of T cell metabolism is crucial for activation, differentiation, survival and function in vivo.
We aim to better characterize nutrient-sensing pathways in T cells. We use biochemical and metabolomic techniques to understand what fuel is needed for immune cell function, and how immune cells sense the fuel that is available in their environment.
Complete these steps before you reach out to a faculty member!
- Familiarize yourself with program requirements. You want to learn as much as possible from the information available to you before you reach out to a faculty member. Be sure to visit the graduate degree program listing and program-specific websites.
- Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. This is either indicated in the program profile under "Admission Information & Requirements" - "Prepare Application" - "Supervision" or on the program website.
- Identify specific faculty members who are conducting research in your specific area of interest.
- Establish that your research interests align with the faculty member’s research interests.
- Read up on the faculty members in the program and the research being conducted in the department.
- Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Be certain that their research is indeed what you are hoping to study.
- Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles.
- Do not send non-specific, mass emails to everyone in the department hoping for a match.
- Address the faculty members by name. Your contact should be genuine rather than generic.
- Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. The supervision enquiry form guides you with targeted questions. Ensure to craft compelling answers to these questions.
- Highlight your achievements and why you are a top student. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest.
- Demonstrate that you are familiar with their research:
- Convey the specific ways you are a good fit for the program.
- Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting.
- Be enthusiastic, but don’t overdo it.
G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application.
ADVICE AND INSIGHTS FROM UBC FACULTY ON REACHING OUT TO SUPERVISORS
These videos contain some general advice from faculty across UBC on finding and reaching out to a potential thesis supervisor.
- CD8+ T cells pass the acid test (2023)
Nature Metabolism, 5 (2), 201-202
- Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice (2023)
- Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function (2023)
Nature Immunology, 24 (3), 516-530
- A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms (2022)
Development (Cambridge, England), 149 (6)
- Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells (2022)
Cytotherapy, 24 (11), 1121-1135
- Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice (2022)
- Executive CoAching unleashes Tc22 anti-tumor capacity (2022)
Science immunology, 7 (67), eabn9190
- PTEN is required for human Treg suppression of costimulation (2022)
- PTEN is required for human Treg suppression of costimulation in vitro (2022)
European Journal of Immunology, 52 (9), 1482-1497
- Transsulfuration, minor player or crucial for cysteine homeostasis in cancer (2022)
Trends in Cell Biology,
- Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation (2022)
Frontiers in Cardiovascular Medicine, 9
- Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. (2021)
Proceedings of the National Academy of Sciences of the United States of America,
- Metabolomic Identification of Alpha-Ketoglutaric Acid Elevation in Pediatric Chronic Graft-versus-Host Disease. (2021)
- Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. (2021)
- Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. (2020)
- EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. (2020)
Genes & development,
- IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. (2020)
- Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. (2020)
- Triacylglycerol synthesis enhances macrophage inflammatory function (2020)
- Triacylglycerol synthesis enhances macrophage inflammatory function. (2020)
- Acetate Promotes T Cell Effector Function during Glucose Restriction. (2019)
- Establishment of a transgenic mouse to model ETV7 expressing human tumors (2019)
- Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. (2019)
- The importance of methionine metabolism (2019)
- The metabolic tug of war between HIV and T cells (2019)
Nature Metabolism, 1 (7), 653--655
- A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways (2018)
Nature Communications, 9 (1)
- ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer (2018)
Science Advances, 4 (9)
- Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2 (2018)
Immunity, 49 (6), 1021-1033.e6
- Unraveling the Complex Interplay between T Cell Metabolism and Function (2018)
Annual Review of Immunology, 36, 461-488
- Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming (2017)
Immunity, 46 (4), 525-527
- Mitochondrial Priming by CD28 (2017)
Cell, 171 (2), 385-397.e11
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming (2016)
Cell, 166 (1), 63-76
- High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells (2015)
Leukemia Research, 39 (8), 906-912
- Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathway (2014)
DMM Disease Models and Mechanisms, 7 (2), 265-270
- PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis (2013)
Neoplasia (United States), 15 (7), 738-748
- MN1 overexpression is an important step in the development of inv(16) AML (2007)
Leukemia, 21 (8), 1679-1690
- Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes (2005)
Blood, 106 (8), 2663-2670