Ramon Klein Geltink
Assistant Professor
Research Classification
Research Interests
Metabolism
Immunotherapy
Cell Signaling and Infectious and Immune Diseases
Auto-Immune Diseases
Cell Therapy of Cancer
Adoptive cellular therapy
Immunometabolism
T cell function
Relevant Thesis-Based Degree Programs
Research Methodology
Stable isotope tracing
Seahorse extracellular flux analysis
Targeted and untargeted metabolomics
Recruitment
Master's students
Doctoral students
Any time / year round
My research program at UBC/BCCHRI aims to better understand how the immune system can be used to treat childhood diseases. In children with cancer, the immune system is no longer able to rid the body of cancerous cells. In children with autoimmune diseases the immune system gets rid of healthy cells of the body. We are particularly interested in the metabolism of immune cells.
Cellular metabolism consists of a complex network of biochemical pathways crucial for energy homeostasis and the generation of biomass to facilitate cell proliferation. In rapidly dividing T cells this is especially demanding, and often associated with ‘Warburg metabolism” or aerobic glycolysis. Regulation of CD8+ T cell fate and function is strongly linked to differences in metabolic reprogramming. The flexibility of T cell metabolism is crucial for activation, differentiation, survival and function in vivo.
We aim to better characterize nutrient-sensing pathways in T cells. We use biochemical and metabolomic techniques to understand what fuel is needed for immune cell function, and how immune cells sense the fuel that is available in their environment.
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Graduate Student Supervision
Master's Student Supervision
Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
Pathology and Laboratory Medicine (2023)
No abstract available.
Purine catabolism as a modulator of macrophage activation (2023)
The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.
View record
Publications
- CD8+ T cells pass the acid test (2023)
Nature Metabolism, 5 (2), 201-202 - Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice (2023)
Diabetes, - Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function (2023)
Nature Immunology, 24 (3), 516-530 - A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms (2022)
Development (Cambridge, England), 149 (6) - Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells (2022)
Cytotherapy, 24 (11), 1121-1135 - Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice (2022)
- Executive CoAching unleashes Tc22 anti-tumor capacity (2022)
Science immunology, 7 (67), eabn9190 - PTEN is required for human Treg suppression of costimulation (2022)
bioRxiv, - PTEN is required for human Treg suppression of costimulation in vitro (2022)
European Journal of Immunology, 52 (9), 1482-1497 - Transsulfuration, minor player or crucial for cysteine homeostasis in cancer (2022)
Trends in Cell Biology, - Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation (2022)
Frontiers in Cardiovascular Medicine, 9 - Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. (2021)
Proceedings of the National Academy of Sciences of the United States of America, - Metabolomic Identification of Alpha-Ketoglutaric Acid Elevation in Pediatric Chronic Graft-versus-Host Disease. (2021)
Blood, - Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. (2021)
Cancer discovery, - Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. (2020)
Cell metabolism, - EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. (2020)
Genes & development, - IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. (2020)
PLoS pathogens, - Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. (2020)
Nature metabolism, - Triacylglycerol synthesis enhances macrophage inflammatory function (2020)
- Triacylglycerol synthesis enhances macrophage inflammatory function. (2020)
Nature communications, - Acetate Promotes T Cell Effector Function during Glucose Restriction. (2019)
Cell reports, - Establishment of a transgenic mouse to model ETV7 expressing human tumors (2019)
Transgenic Research, - Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. (2019)
Cell metabolism, - The importance of methionine metabolism (2019)
eLife, 8 - The metabolic tug of war between HIV and T cells (2019)
Nature Metabolism, 1 (7), 653--655 - A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways (2018)
Nature Communications, 9 (1) - ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer (2018)
Science Advances, 4 (9) - Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2 (2018)
Immunity, 49 (6), 1021-1033.e6 - Unraveling the Complex Interplay between T Cell Metabolism and Function (2018)
Annual Review of Immunology, 36, 461-488 - Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming (2017)
Immunity, 46 (4), 525-527 - Mitochondrial Priming by CD28 (2017)
Cell, 171 (2), 385-397.e11 - Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming (2016)
Cell, 166 (1), 63-76 - High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells (2015)
Leukemia Research, 39 (8), 906-912 - Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathway (2014)
DMM Disease Models and Mechanisms, 7 (2), 265-270 - PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis (2013)
Neoplasia (United States), 15 (7), 738-748 - MN1 overexpression is an important step in the development of inv(16) AML (2007)
Leukemia, 21 (8), 1679-1690 - Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes (2005)
Blood, 106 (8), 2663-2670
Membership Status
Member of G+PS
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Location
BC Children's Hospital
Program Affiliations
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