Ramon Klein Geltink
Relevant Degree Programs
My research program at UBC/BCCHRI aims to better understand how the immune system can be used to treat childhood diseases. In children with cancer, the immune system is no longer able to rid the body of cancerous cells. In children with autoimmune diseases the immune system gets rid of healthy cells of the body. We are particularly interested in the metabolism of immune cells.
Cellular metabolism consists of a complex network of biochemical pathways crucial for energy homeostasis and the generation of biomass to facilitate cell proliferation. In rapidly dividing T cells this is especially demanding, and often associated with ‘Warburg metabolism” or aerobic glycolysis. Regulation of CD8+ T cell fate and function is strongly linked to differences in metabolic reprogramming. The flexibility of T cell metabolism is crucial for activation, differentiation, survival and function in vivo.
We aim to better characterize nutrient-sensing pathways in T cells. We use biochemical and metabolomic techniques to understand what fuel is needed for immune cell function, and how immune cells sense the fuel that is available in their environment.
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- Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. (2021)
Proceedings of the National Academy of Sciences of the United States of America,
- Metabolomic Identification of Alpha-Ketoglutaric Acid Elevation in Pediatric Chronic Graft-versus-Host Disease. (2021)
- Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. (2021)
- Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. (2020)
- EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. (2020)
Genes & development,
- IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. (2020)
- Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. (2020)
- Triacylglycerol synthesis enhances macrophage inflammatory function (2020)
- Triacylglycerol synthesis enhances macrophage inflammatory function. (2020)
- Acetate Promotes T Cell Effector Function during Glucose Restriction. (2019)
- Establishment of a transgenic mouse to model ETV7 expressing human tumors (2019)
- Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. (2019)
- The importance of methionine metabolism (2019)
- The metabolic tug of war between HIV and T cells (2019)
Nature Metabolism, 1 (7), 653--655
- A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways (2018)
Nature Communications, 9 (1)
- ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer (2018)
Science Advances, 4 (9)
- Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2 (2018)
Immunity, 49 (6), 1021-1033.e6
- Unraveling the Complex Interplay between T Cell Metabolism and Function (2018)
Annual Review of Immunology, 36, 461-488
- Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming (2017)
Immunity, 46 (4), 525-527
- Mitochondrial Priming by CD28 (2017)
Cell, 171 (2), 385-397.e11
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming (2016)
Cell, 166 (1), 63-76
- High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells (2015)
Leukemia Research, 39 (8), 906-912
- Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathway (2014)
DMM Disease Models and Mechanisms, 7 (2), 265-270
- PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis (2013)
Neoplasia (United States), 15 (7), 738-748
- MN1 overexpression is an important step in the development of inv(16) AML (2007)
Leukemia, 21 (8), 1679-1690
- Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes (2005)
Blood, 106 (8), 2663-2670