Desmond Nunez

Associate Professor

Research Classification

Neurodegenerative Diseases
Inflammatory Respiratory Diseases

Research Interests

Age Related Hearing Loss
Sudden Sensorineural Hearing Loss
Recurrent Acute Otitis Media
 
 

Research Methodology

porcine cell culture
Immunocytochemistry
Audiometry

Recruitment

Master's students
Doctoral students
Any time / year round
I support public scholarship, e.g. through the Public Scholars Initiative, and am available to supervise students and Postdocs interested in collaborating with external partners as part of their research.

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Graduate Student Supervision

Master's Student Supervision (2010 - 2020)
Sudden sensorineural hearing loss (2020)

ObjectiveThe purpose of this study is to evaluate the effectiveness of oral, intratympanic steroid (IT) and Hyperbaric Oxygen therapy (HBOT) based treatments on hearing outcomes in patients with Sudden sensorineural hearing loss (SSNHL). Methods A systematic review of primary studies published in the English language between January 2000 to June 2018 identified by searching Medline, PubMed, Web of Science, and Embase databases was performed. Inclusion criteria were Primary articles on the treatment with (oral, IT steroid and HBOT) of patients diagnosed as having SSNHL. Patients with all other types of hearing loss were excluded. A retrospective chart review of patients presenting with SSNHL at Vancouver general hospital from 2015 to 2017 was also performed. The outcomes studied include; Averaged PTA threshold change between pre/posttreatment.Results 223 articles were identified of which 24 articles meet the study inclusion criteria. The quality of evidence was good in 20 articles, and poor in the remaining 4 articles. Overall, 90% of 687 patients in the 8 studies who received oral and IT steroids (combination therapy) and 86% 0f 494 patients in the 5 studies who received triple therapy with HBOT demonstrated hearing recovery compared to a 75% recovery rate in 548 patients who received oral steroids alone. Combination therapy had statistically significant hearing improvement compared with oral steroids alone (Chi squared, p 15db) noticed in patient groups of prednisone alone and prednisone + IT and IT alone (p
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Publications

 
 

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