Bruce Carleton

Professor

Research Interests

Pharmacogenomics
Adverse drug reactions (ADRs)
Drug safety and effectiveness
Clinical pharmacology
Pharmacovigilance

Relevant Degree Programs

 

Research Methodology

genotyping, sequencing, genomic analysis, statistical genetics

Recruitment

Master's students
Doctoral students
Postdoctoral Fellows
Some financial support is available
Any time / year round

There are numerous opportunities for pursuing doctoral and post-doctoral research using state of the art genotyping and sequencing platforms to identify the genetic determinants of severe adverse drug reactions (ADRs) in paediatric and adult populations. In close collaboration with the CPNDS active surveillance network, genetic association and validation studies are being performed to define ADR causal genes and to develop diagnostic tests to offer personalized therapeutic recommendations for commonly used drugs. Current pharmacogenomics and surveillance focuses are: cisplatin, anthracyclines, vincristine, warfarin, codeine, inhaled corticosteroids, 5-HT3 antagonists (antiemetics), and drugs used in the treatment of Hepatitis C. Other projects include the development of clinical practice guidelines for six drugs, and knowledge translation to implement pharmacogenomic testing in clinical practice.

I am open to hosting Visiting International Research Students (non-degree, up to 12 months).

Graduate Student Supervision

Doctoral Student Supervision (since 2008)

Membership Status

Member of G+PS

Department(s)

 

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