Marek Budzynski

Postdoctoral Fellow


Cells that are the building blocks of the organism come in different forms and functions. Stem cells are a unique type of cells, because of their ability to change (differentiate) or maintain their state. Because of this ability to differentiate into any type of cell, stem cells are on the frontiers of regenerative medicine, which is aimed to restore damaged cells, tissues or organs. The cell division (mitosis) poses a challenge for cell identity. During mitosis, the DNA is condensed into characteristic mitotic chromosomes, the nuclear membrane, separating DNA from rest of the cell, is fragmented, and the gene expression ceases. How then cells memorized which genes were expressed, to continue their expression after mitosis? The mitotic memory has been proposed as a mechanism for the maintenance of cell identity after mitosis. One arm of this mechanism, called bookmarking, is the binding of transcription factors (proteins regulating gene expression), to mitotic DNA. My research aims to establish the molecular mechanisms of mitotic bookmarking in mouse embryonic stem cells. Using methods, such as gene editing, genomics, and imaging, I am solving how stem cells maintain their identity after countless number of cell division.



Research Interests

Stem Cells
transcription factors
Cell division
Stress responses

Research Methodology

Tissue Culture
ChIP and ChIP-seq
CUT&Tag and CUT&Run
hight-throughput sequencing
cell line engineering
live cell imaging
stem cells

Research Centres, Clusters, Institutes

Research Options

I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.

If this is your researcher profile you can log in to the Faculty & Staff portal to update your details.