Myeong Jin Ju
Assistant Professor
Research Classification
Research Interests
algorithms for quantitatively imaging biological dynamics in human retina
cellular resolution functional retinal imaging systems
Medical Imaging
optical imaging systems
signal processing algorithms
Relevant Thesis-Based Degree Programs
Graduate Student Supervision
Master's Student Supervision
Theses completed in 2010 or later are listed below. Please note that there is a 6-12 month delay to add the latest theses.
Functional 3D retinal imaging using OCT technology and a novel, system-agnostic registration algorithm (2023)
Optical coherence tomography (OCT) is a non-invasive optical imaging technique to capture in-vivo, three-dimensional (3D) image data with micrometer resolution. OCT has become a valuable tool for ophthalmologists in detecting and monitoring eye diseases like age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) by providing valuable information for diagnosis and determining the best course of treatment. OCT angiography (OCTA) is a functional extension of OCT which allows for non-invasive visualization of blood flow in the retina and choroid. OCTA provides detailed information about microvasculature, which is not possible with traditional angiography techniques. However, OCT and OCTA images are susceptible to degradation from motion artifacts induced by the involuntary human subjects’ head and eye movement. Multi-volume acquisition and averaging is a software-based approach to correct the motion artifacts by registering several motion-corrupted images to a single reference image or multiple reference images in a post-processing step. Nonetheless, most software-based algorithms have been more specifically designed for a specific system with a limited field-of-view (FOV) range. In this study, we implemented a robust 3D algorithm for the precise registration of multiple volumes to the coordinates of one volume chosen as the reference volume. Tests were carried out on various datasets obtained from different types of custom-built and commercially available systems to determine the reliability of the proposed algorithm. A two-dimensional (2D) version of this method is then applied to investigate retinal perfusion heterogeneity, which may enhance our understanding of retinal diseases such as glaucoma.
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Publications
- Deep learning vessel segmentation and quantification of the foveal avascular zone using commercial and prototype OCT-A platforms (2019)
arXiv preprint arXiv:1909.11289, - Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium (2019)
Journal of biomedical optics, 24 (6), 066011 - High-resolution pigment and flow imaging with multi-scale sensorless adaptive optics OCT (2019)
Investigative Ophthalmology & Visual Science, 60 (9), 3083--3083 - Jones matrix OCT system and program for carrying out image processing on measured data obtained by said OCT (2019)
- Machine Learning Based End-to-End Pipeline for Optical Coherence Tomography Angiography of Diabetic Retinopathy (2019)
Investigative Ophthalmology & Visual Science, 60 (9), 2204--2204 - Multi-acquisition averaging OCT-A for diabetic retinopathy (Conference Presentation) (2019)
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 10867, 108671C - Multi-acquisition averaging optical coherence tomography angiography for diabetic retinopathy (2019)
Investigative Ophthalmology & Visual Science, 60 (11), PB064--PB064 - Multi-scale and-contrast sensorless adaptive optics optical coherence tomography (2019)
Quantitative Imaging in Medicine and Surgery, 9 (5), 757--768 - Multi-scale and-mode sensorless adaptive optics OCT for in vivo human retinal imaging (Conference Presentation) (2019)
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 10867, 1086721 - Non-invasive cellular-resolution retinal imaging with two-photon excited fluorescence (2019)
Biomedical optics express, 10 (9), 4859--4873 - Real-time retinal layer segmentation for high-resolution OCT angiography (2019)
Investigative Ophthalmology & Visual Science, 60 (9), 156--156 - Sensorless Adaptive Optics for Two Photon Excited Fluorescence Imaging of the Mouse Retina (2019)
Investigative Ophthalmology & Visual Science, 60 (9), 4598--4598 - Sensorless adaptive optics multimodal en-face small animal retinal imaging (2019)
Biomedical optics express, 10 (1), 252--267 - Sensorless adaptive optics optical coherence tomography for two photon excited fluorescence mouse retinal imaging (2019)
Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 11078, 110781L - Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image (2019)
Journal of biomedical optics, 24 (3), 036006 - Visible-light sensorless adaptive optics optical coherence tomography of retinal response to laser exposure (2019)
Investigative Ophthalmology & Visual Science, 60 (11), PB028--PB028 - Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning (2018)
Biomedical optics express, 9 (11), 5353--5367 - Clinical retinal imaging with Sensorless Adaptive Optics OCT and Angiography (2018)
Investigative Ophthalmology & Visual Science, 59 (9), 1972--1972 - Deep Neural Network Based Quantification of Retinal Optical Coherence Tomography Images (2018)
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), - Effective bidirectional scanning pattern for optical coherence tomography angiography (2018)
Biomedical optics express, 9 (5), 2336--2350 - Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography (2018)
Ophthalmic Technologies XXVIII, 10474, 104742B - Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye (2018)
Experimental eye research, 170, 13--19 - Systems and Methods for Angiography and Motion Corrected Averaging (2018)
- Visible light sensorless adaptive optics for retinal structure and fluorescence imaging (2018)
Optics letters, 43 (20), 5162--5165 - Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage (2017)
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 10053, 1005319 - Data-based online nonlinear extremum-seeker for wavefront sensorless adaptive optics OCT (Conference Presentation) (2017)
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 10053, 1005327 - GPU accelerated optical coherence tomography angiography using strip-based registration (Conference Presentation) (2017)
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 10053, 1005306 - Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging (2017)
Journal of biomedical optics, 22 (12), 121703 - Progress on wavefront sensorless adaptive optics (2017)
2017 IEEE Photonics Conference (IPC), , 593--594 - Real time optimization algorithm for wavefront sensorless adaptive optics OCT (Conference Presentation) (2017)
Adaptive Optics and Wavefront Control for Biological Systems III, 10073, 100731B - Strip-based registration of serially acquired optical coherence tomography angiography (2017)
Journal of biomedical optics, 22 (3), 036007 - Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging (2017)
Biomedical optics express, 8 (4), 2261--2275 - Wide-field human photoreceptor morphological analysis using phase-resolved sensorless adaptive optics swept-source OCT (Conference Presentation) (2017)
Ophthalmic Technologies XXVII, 10045, 1004513 - Lens-based wavefront sensorless adaptive optics swept source OCT (2016)
Scientific reports, 6, 27620 - Retinal optical coherence tomography at 1 $μ$m with dynamic focus control and axial motion tracking (2016)
Journal of biomedical optics, 21 (2), 026007 - Jones Matrix based polarization sensitive optical coherence tomography (2015)
Optical Coherence Tomography: Technology and Applications, , 1137--1162 - Usage of polarization-sensitive optical coherence tomography for investigation of collagen cross-linking (2015)
Journal of biomedical optics, 20 (4), 046001 - Simultaneous investigation of vascular and retinal pigment epithelial pathologies of exudative macular diseases by multifunctional optical coherence tomography (2014)
Investigative ophthalmology & visual science, 55 (8), 5016--5031 - Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography (2014)
Journal of biomedical optics, 19 (3), 030503 - Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging (2013)
Optics express, 21 (16), 19412--19436 - In vivo three-dimensional investigation of tissue birefringence by Jones matrix tomography (2013)
2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR), - Noninvasive investigation of deep vascular pathologies of exudative macular diseases by high-penetration optical coherence angiography (2013)
Investigative ophthalmology & visual science, 54 (5), 3621--3631 - Simultaneous 3D Doppler and Polarization Imaging of Macular Pathologies by Polarization-Sensitive Optical Coherence Angiography (2013)
Investigative Ophthalmology & Visual Science, 54 (15), 3165--3165 - Simultaneous birefringence and flow imaging with Multifunctional Jones matrix optical coherence tomography (2013)
Investigative Ophthalmology & Visual Science, 54 (15), 394--394 - Three-dimensional polarization and Doppler imaging of living tissue by multi-contrast optical coherence tomography (2013)
CLEO: Science and Innovations, , CTu2M--3 - Visualization and Automatic Diameter Evaluation of In Vivo Choroidal Vessels by High-Penetration Optical Coherence Tomography (2013)
Investigative Ophthalmology & Visual Science, 54 (15), 2641--2641 - High-penetration swept source Doppler optical coherence angiography by fully numerical phase stabilization (2012)
Optics express, 20 (3), 2740--2760 - Multimodal optical imaging with multiphoton microscopy and optical coherence tomography (2012)
Journal of biophotonics, 5 (5-6), 396--403 - Multimodal Optical Tissue Imaging (2012)
2012 Symposium on Photonics and Optoelectronics, , 1--3 - Non-invasive vascular imaging of exudative macular disease by high penetration Doppler optical coherence angiography (2012)
Investigative Ophthalmology & Visual Science, 53 (14), 1152--1152 - 2$\times$ 2 photonic crystal fiber splitter for 800 nm spectral domain optical coherence tomography (2011)
Physics and Simulation of Optoelectronic Devices XIX, 7933, 79332C - Choroidal Blood Flow Imaging with High Penetration Doppler Optical Coherence Tomography (2011)
Investigative Ophthalmology & Visual Science, 52 (14), 1245--1245 - Integrating optical system designed for multimodal analysis of pearls and its mother oyster to distinguish and appraise cultured pearls (2011)
Multimodal Biomedical Imaging VI, 7892, 78920T - Multimodal analysis of pearls and pearl treatments by using optical coherence tomography and fluorescence spectroscopy (2011)
Optics express, 19 (7), 6420--6432 - Non-invasive three-dimensional angiography of human eye by Doppler optical coherence tomography (2011)
Conference on Lasers and Electro-Optics/Pacific Rim, , C1073 - Combined swept-source optical coherence tomography and fluorescence spectroscopy system (2010)
Multimodal Biomedical Imaging V, 7557, 75570W - Common-path optical frequency domain imaging system designed for identifying and grading pearls (2010)
Design and Quality for Biomedical Technologies III, 7556, 755613 - Evaluating and identifying pearls and their nuclei by using optical coherence tomography (2010)
Optics express, 18 (13), 13468--13477 - Specialty fiber coupler: fabrications and applications (2010)
Journal of the Optical Society of Korea, 14 (4), 326--332 - The development of double clad fiber and double clad fiber coupler for fiber based biomedical imaging systems (2009)
Journal of the Optical Society of Korea, 13 (3), 310--315
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