Professor
Research Classification
Research Interests
depression
Biomarkers
light therapy
cognition
digital technologies
bipolar disorder
antidepressants
global mental health
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
Biography
I am a clinical psychiatrist specializing in the research and care of people with mood disorders including depression and bipolar disorder. My research examines clinical and neurobiological factors in seasonal, treatment-resistant and workplace depression, biological and therapeutic effects of light, clinical trials, biomarkers, clinical guidelines, digital health technology, and global mental health.
My clinical trials involve the spectrum of depression treatments from pharmacologic (antidepressant medications, mood stabilizers) to non-pharmacologic (light therapy, telephone-administered cognitive behaviour therapy) to neuromodulatory (repetitive transcranial magnetic stimulation, deep brain stimulation for treatment refractory depression), and are funded by agencies including the Canadian Institutes of Health Research and by industry sponsors.
I am also actively involved in evidence-based medicine as an editorial advisor for the Cochrane Collaboration and in knowledge translation through development and dissemination of clinical practice guidelines, including the internationally-used and widely-cited CANMAT guidelines for depression and bipolar disorder.
I have authored or co-authored over 570 scientific articles, including more than 450 papers in peer-reviewed journals and 11 books on depression. I am on the editorial boards of 4 international journals and serve as Associate Editor for the Canadian Journal of Psychiatry.
My clinical trials involve the spectrum of depression treatments from pharmacologic (antidepressant medications, mood stabilizers) to non-pharmacologic (light therapy, telephone-administered cognitive behaviour therapy) to neuromodulatory (repetitive transcranial magnetic stimulation, deep brain stimulation for treatment refractory depression), and are funded by agencies including the Canadian Institutes of Health Research and by industry sponsors.
I am also actively involved in evidence-based medicine as an editorial advisor for the Cochrane Collaboration and in knowledge translation through development and dissemination of clinical practice guidelines, including the internationally-used and widely-cited CANMAT guidelines for depression and bipolar disorder.
I have authored or co-authored over 570 scientific articles, including more than 450 papers in peer-reviewed journals and 11 books on depression. I am on the editorial boards of 4 international journals and serve as Associate Editor for the Canadian Journal of Psychiatry.
Research Methodology
light therapy devices
smartphone apps
Systematic Reviews
Publications
- “One Degree of Separation”: A Mixed-Methods Evaluation of Canadian Mental Health Care User and Provider Experiences With Remote Care During COVID-19 (2022)
The Canadian Journal of Psychiatry, , 070674372110706 - Advancing Implementation Science Measurement for Global Mental Health Research (2022)
The Canadian Journal of Psychiatry, - Biophysical compartment models for single-shell diffusion MRI in the human brain: a model fitting comparison (2022)
Physics in Medicine & Biology, 67 (5), 055009 - Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2022)
The Canadian Journal of Psychiatry, - Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A Canadian Biomarker Integration Network for Depression Study (2022)
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, - Rhythmicity of sleep and clinical outcomes in major depressive disorder: A CAN-BIND-1 report (2022)
Journal of Affective Disorders Reports, - Subcutaneous and Intramuscular Parental Ketamine for Treatment of Depression: Clinical Treatment Protocol (2022)
- The Effectiveness of Internet-guided Self-help Interventions to Promote Physical Activity Among Individuals with Depression: Systematic Review (Preprint) (2022)
- Using Machine Learning to Predict Remission in Patients With Major Depressive Disorder Treated With Desvenlafaxine (2022)
The Canadian Journal of Psychiatry, 67 (1), 39--47 - Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report (2021)
Translational Psychiatry, - Cognition and Its Association with Psychosocial and Occupational Functioning during Treatment with Escitalopram in Patients with Major Depressive Disorder: A CAN-BIND-1 Report: La Cognition Et Son Association Avec Le Fonctionnement Psychosocial Et Profess (2021)
The Canadian Journal of Psychiatry, , 070674372097482 - EMBED Phase 2 Study Protocol v.1.4: A Cluster Randomized Controlled Trial of Enhanced versus Standard Measurement-Based Care Implementation for Depression (2021)
- Exploring the Effects of Temperament on Gray Matter Volume of Frontal Cortex in Patients with Mood Disorders (2021)
Neuropsychiatric Disease and Treatment, - Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians (2021)
Neuropsychiatric Disease and Treatment, - Mental Health Service Challenges during the Early Stage of the COVID-19 Pandemic: Experience and Best Practices from China (2021)
The Canadian Journal of Psychiatry, , 070674372097225 - Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report (2021)
Communications Biology, - Our Digital Moment: Innovations and Opportunities in Digital Mental Health Care (2021)
The Canadian Journal of Psychiatry, , 070674372093783 - Patient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression: An Online Survey Study (2021)
- Probing the clinical and brain structural boundaries of bipolar and major depressive disorder (2021)
Translational Psychiatry, - Quality of Life Impacts of Bright Light Treatment, Fluoxetine, and the Combination in Patients with Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial (2021)
The Canadian Journal of Psychiatry, , 070674372093647 - The Quality of Life in Bipolar Disorder (QoL.BD) questionnaire a decade on – A systematic review of the measurement of condition-specific aspects of quality of life in bipolar-disorder (2021)
Journal of Affective Disorders, 278, 33--45 - Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response (2021)
Translational Psychiatry, - Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: a longitudinal magnetic resonance spectroscopy study (2021)
Psychological Medicine, The APEC Digital Hub-WONCA Collaborative Framework on Integration of Mental Health into Primary Care in the Asia Pacific
(2020)
Journal of Multidisciplinary Healthcare,- A Randomized Sham-controlled Trial of 1-Hz and 10-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) of the Right Dorsolateral Prefrontal Cortex in Civilian Post-traumatic Stress Disorder: Un essai randomisé contrôlé simulé de stimulation magnétique t (2020)
The Canadian Journal of Psychiatry, , 070674372092306 - Association of Serum Vitamin D Levels with Depression in Adults: A Nationwide Population-based Study in Korea (2020)
- Cannabidiol as a Treatment for Mood Disorders: A Systematic Review: Le cannabidiol comme traitement des troubles de l’humeur: une revue systématique (2020)
The Canadian Journal of Psychiatry, 65 (4), 213--227 - Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials (2020)
The Canadian Journal of Psychiatry, 65 (5), 290--300 - Discrepancy between objective and subjective cognition in major depressive disorder. (2019)
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, - Men’s Work-Related Stress and Mental Health: Illustrating the Workings of Masculine Role Norms (2019)
American Journal of Men's Health, 13 (2), 155798831983841 - Risperidone adjunctive therapy duration in the maintenance treatment of bipolar I disorder: A post hoc analysis (2019)
Journal of Affective Disorders, 246, 861--866 - Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study. (2019)
Bipolar disorders, - A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR (2018)
Int J Neuropsychopharmacol, 21 (2), 108-113 - Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder (2018)
Bipolar Disorders, - Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report. (2018)
Psychological medicine, - Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial (2018)
The Lancet, - Efficacy and tolerability of lisdexamfetamine as an antidepressant augmentation strategy: A meta-analysis of randomized controlled trials (2018)
Journal of Affective Disorders, - Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression (2018)
American Journal of Psychiatry, - Implications of Cannabis Legalization on Youth and Young Adults (2018)
Can J Psychiatry, 63 (1), 65-71 - Implications of Cannabis Legalization on Youth and Young AdultsY (2018)
Canadian Journal of Psychiatry, - Psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D) instrument in US and UK respondents with major depressive disorder (2018)
Neuropsychiatric Disease and Treatment, - Revising Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for the bipolar disorders: Phase I of the AREDOC project. (2018)
The Australian and New Zealand journal of psychiatry, - Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers (2018)
International Journal of Methods in Psychiatric Research, - The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study (2018)
J Affect Disord, 227, 542-549 - Use of Placebo in Clinical Trials of Psychotropic Medication (2018)
Canadian Journal of Psychiatry, - A Longitudinal Study of the Relationships Between Mood Symptoms, Body Mass Index, and Serum Adipokines in Bipolar Disorder (2017)
J Clin Psychiatry, 78 (4), 441-448 - A multicomponent intervention for the management of chronic pain in older adults: study protocol for a randomized controlled trial (2017)
Trials, - A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder (2017)
J Neurosci Methods, 290, 57-68 - Adjunctive ketamine in electroconvulsive therapy: updated systematic review and meta-analysis (2017)
Br J Psychiatry, 210 (6), 403-407 - APEC digital hub for mental health (2017)
The Lancet Psychiatry, - Chronic Schizophrenia and Idiopathic Parkinson's Disease (2017)
Canadian Journal of Psychiatry, - Cognitive impairment as measured by the THINC-integrated tool (THINC-it): Association with psychosocial function in major depressive disorder (2017)
Journal of Affective Disorders, - Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management (2017)
J Clin Psychiatry, 78 (9), 1383-1394 - Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder (2017)
Transl Psychiatry, 7 (3), e1071 - Effect of desvenlafaxine 50 mg and 100 mg on energy and lassitude in patients with major depressive disorder: A pooled analysis (2017)
J Psychopharmacol, 31 (9), 1204-1214 - Efficacy of Vortioxetine on Cognitive Functioning in Working Patients With Major Depressive Disorder (2017)
J Clin Psychiatry, 78 (1), 115-121 - Impact of Cognitive Impairment on Functioning in Patients With Depression (2017)
J Clin Psychiatry, 78 (9), e1430 - L-Tryptophan Augmentation of Light Therapy in Patients with Seasonal Affective Disorder (2017)
Canadian Journal of Psychiatry, - Lower cognitive functioning as a predictor of weight gain in bipolar disorder: a 12-month study (2017)
Acta Psychiatr Scand, 135 (3), 239-249 - Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study (2017)
Lancet Psychiatry, 4 (3), 208-217 - MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes (2017)
Nat Commun, 8, 15497 - Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement (2017)
World J Biol Psychiatry, , 1-19 - Obtaining a Family Psychiatric History: Is it Worth the Effort? (2017)
Canadian Journal of Psychiatry, - Quality of life in bipolar disorder: towards a dynamic understanding (2017)
Psychol Med, , 1-10 - Rating Short-Term Psychodynamic Therapy for the Canadian Network for Mood and Anxiety Treatments Depression Guidelines (2017)
Can J Psychiatry, 62 (1), 77-78 - Response to Letter Regarding CANMAT Recommendations for the Pharmacological Treatment of Late-life Depression (2017)
Can J Psychiatry, 62 (5), 353-354 - Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression (2017)
Sci Rep, 7 (1), 7473 - Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial (2017)
Lancet Psychiatry, 4 (11), 839-849 - Subcortical structural volumes in recently remitted first episode mania (2017)
J Affect Disord, 222, 23-27 - The effect of remission status on work functioning in employed patients treated for major depressive disorder (2017)
Annals of Clinical Psychiatry, - The Efficacy of Psychostimulants in Major Depressive Episodes: A Systematic Review and Meta-Analysis (2017)
J Clin Psychopharmacol, 37 (4), 412-418 - The impact of fatigue and energy on work functioning and impairment in patients with major depressive disorder treated with desvenlafaxine (2017)
Int Clin Psychopharmacol, 32 (6), 343-349 - The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder (2017)
J Clin Psychiatry, 78 (7), 873-881 - Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2017)
J Affect Disord, 208, 291-297 - Treatment of Seasonal Affective Disorder: A Review (2017)
Canadian Journal of Psychiatry, - A Community-Based Clinic Survey of Antidepressant Use in Persons with Schizophrenia (2016)
Canadian Journal of Psychiatry, - Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder (2016)
Psychoneuroendocrinology, 65, 76-83 - Breaking the myths: New treatment approaches for chronic depression (2016)
Canadian Journal of Psychiatry, - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Introduction and Methods (2016)
Can J Psychiatry, 61 (9), 506-9 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 2. Psychological Treatments (2016)
Can J Psychiatry, 61 (9), 524-39 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments (2016)
Can J Psychiatry, 61 (9), 540-60 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments (2016)
Can J Psychiatry, 61 (9), 561-75 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 5. Complementary and Alternative Medicine Treatments (2016)
Can J Psychiatry, 61 (9), 576-87 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly (2016)
Can J Psychiatry, 61 (9), 588-603 - Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section I. Disease Burden and Principles of Care (2016)
Canadian Journal of Psychiatry, - Clinical Predictors of Short-Term Outcome in Electroconvulsive Therapy (2016)
Canadian Journal of Psychiatry, - Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort (2016)
BMC Psychiatry, 16, 105 - Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder a randomized clinical trial (2016)
JAMA Psychiatry, 73 (1), 56-63 - Hard Times and Good Friends: Negative Life Events and Social Support in Patients With Seasonal and Nonseasonal Depression (2016)
Canadian Journal of Psychiatry, - Heparin-Based Polyelectrolyte Complex Enhances the Therapeutic Efficacy of Bone Morphogenetic Protein-2 for Posterolateral Fusion in a Large Animal Model (2016)
Spine (Phila Pa 1976), 41 (15), 1199-207 - Ketamine: stimulating antidepressant treatment? (2016)
BJPsych Open, 2 (3), e5-e9 - Midodrine for TCA-induced orthostatic hypotension (2016)
Drug and Therapeutics Bulletin, - Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first-episode mania and association with clinical outcome (2016)
Bipolar Disord, 18 (6), 511-519 - Oxcarbazepine in the Treatment of Bipolar Disorder: A Review (2016)
Canadian Journal of Psychiatry, - Perceived quality of life in patients with bipolar disorder. Does group psychoeducation have an impact? (2016)
Canadian Journal of Psychiatry, - Preferred Features of E-Mental Health Programs for Prevention of Major Depression in Male Workers: Results From a Canadian National Survey (2016)
Journal of Medical Internet Research, 18 (6), e132 - Quality of Life in Patients with Seasonal Affective Disorder: Summer vs Winter Scores (2016)
Canadian Journal of Psychiatry, - Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder (2016)
British Journal of Psychiatry, 208 (2), 146-152 - S-adenosyl methionine (SAMe) for depression in adults (2016)
Cochrane Database Syst Rev, 10, CD011286 - Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials (2016)
Lancet Psychiatry, 3 (12), 1138-1146 - Selection of cognitive tests for trials of therapeutic agents (2016)
Lancet Psychiatry, 3 (6), 499 - Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS) (2016)
Brain Stimul, 9 (1), 156-8 - Structural brain changes in first episode mania with and without psychosis: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2016)
World J Biol Psychiatry, , 1-11 - The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder (2016)
Innov Clin Neurosci, 13 (9-10), 20-31 - The Effects of an E-Mental Health Program and Job Coaching on the Risk of Major Depression and Productivity in Canadian Male Workers: Protocol for a Randomized Controlled Trial (2016)
JMIR Research Protocols, - The effects of desvenlafaxine on neurocognitive and work functioning in employed outpatients with major depressive disorder (2016)
Journal of Affective Disorders, - The Effects of Newer Antidepressants on Occupational Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2016)
CNS Drugs, - Using Metaanalysis to Evaluate Evidence: Practical Tips and Traps (2016)
Canadian Journal of Psychiatry, - A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability (2015)
Journal of Psychiatric Research, 62, 23-30 - A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes (2015)
Psychological Medicine, 45 (4), 693-704 - Canadian Network for Mood and Anxiety Treatments (CANMAT) consensus recommendations for functional outcomes in major depressive disorder (2015)
Annals of Clinical Psychiatry, 27 (2), 142-149 - Corrigendum to "A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability" [J Psychiatr Res (2015) 62: 23-30] (2015)
Journal of Psychiatric Research, 68, 74-75 - Course and outcome following a first episode of mania: Four-year prospective data from the Systematic Treatment Optimization Program (STOP-EM) (2015)
Journal of Affective Disorders, 175, 411-417 - Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy (2015)
Journal of Affective Disorders, 185, 90-96 - Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial (2015)
Molecular Psychiatry, - Recovery and recurrence following a first episode of mania: A systematic review and meta-analysis of prospectively characterized cohorts (2015)
Journal of Clinical Psychiatry, 76 (9), 1241-1248 - STAR*D and Measurement-Based Care for Depression: Don't Toss Out the Baby! (2015)
Canadian Journal of Psychiatry, - STAR∗D and measurement-based care for depression: Don't toss out the baby! (2015)
Canadian Journal of Psychiatry, 60 (1), 6-8 - The relationship between burnout and depressive symptoms in patients with depressive disorders (2015)
Journal of Affective Disorders, 172, 361-366 - Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology (2015)
World Journal of Biological Psychiatry, 16 (4), 249-260 - 12-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder (2014)
Bipolar Disorders, 16 (2), 159-171 - Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014)
BMC Psychiatry, 14 (SUPPL) - Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2014)
Journal of Psychiatric Research, 48 (1), 65-72 - Cognitive change in the year after a first manic episode: Association between clinical outcome and cognitive performance early in the course of bipolar I disorder (2014)
Journal of Clinical Psychiatry, 75 (6) - Cognitive dysfunction in major depressive disorder: Effects on psychosocial functioning and implications for treatment (2014)
Canadian Journal of Psychiatry, 59 (12), 649-654 - Core discrete event simulation model for the evaluation of health care technologies in major depressive disorder (2014)
Value in Health, 17 (2), 183-195 - Early switching strategies in antidepressant non-responders: Current evidence and future research directions (2014)
CNS Drugs, 28 (7), 601-609 - Improvements in quality of life with desvenlafaxine 50 mg/d vs placebo in employed adults with major depressive disorder (2014)
Journal of Affective Disorders, 166, 307-314 - Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression (2014)
Journal of Neuropsychiatry and Clinical Neurosciences, 26 (2), 126-133 - Neurocognitive Functioning in Overweight and Obese Patients With Bipolar Disorder: Data From the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2014)
Canadian Journal of Psychiatry, - Predictors of functional improvement in employed adults with major depressive disorder treated with desvenlafaxine (2014)
International Clinical Psychopharmacology, 29 (5), 239-251 - Research-Track Programs for Residents in Psychiatry: A Review of Literature and a Report of 3 Canadian Experiences (2014)
Canadian Journal of Psychiatry, - The relationship between neurocognitive and psychosocial functioning in major depressive disorder: A systematic review (2014)
Journal of Clinical Psychiatry, 75 (12), 1359-1370 - A double-blind, placebo-controlled study of adjunctive calcitonin nasal spray in acute refractory mania (2013)
Bipolar Disorders, 15 (4), 359-364 - Antidepressants and QTc prolongation (2013)
Journal of Psychiatry and Neuroscience, 38 (2) - Author response (2013)
Journal of psychiatry & neuroscience : JPN, 38 (4), E11-E12 - Body Mass Index-Related Regional Gray and White Matter Volume Reductions in First-Episode Mania Patients (2013)
Biological Psychiatry, - Conceptualising the neurobiology of fatigue (2013)
Australian and New Zealand Journal of Psychiatry, 47 (4), 312-316 - Do the symptoms of bipolar disorder really show seasonal variation? (2013)
Bipolar Disorders, 15 (7), 808-810 - Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder (2013)
British Journal of Psychiatry, 203 (5), 358-365 - Efficacy of second generation antipsychotics in treating acute mixed episodes in bipolar disorder: A meta-analysis of placebo-controlled trials (2013)
Journal of Affective Disorders, 150 (2), 408-414 - Fatigue and occupational functioning in major depressive disorder (2013)
Australian and New Zealand Journal of Psychiatry, 47 (11), 989-991 - Preclinical evaluation of strontium-containing bioactive bone cement (2013)
Materials Science and Engineering: C, - Rapid screening for perceived cognitive impairment in major depressive disorder (2013)
Annals of Clinical Psychiatry, 25 (2), 135-140 - RE: Escitalopram and QTc prolongation (2013)
Journal of Psychiatry and Neuroscience, 38 (4) - Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2013)
Bipolar Disorders, 15 (6), 657-668 - Response to commentaries on the Canadian Network for Mood and Anxiety Treatments/International Society for Bipolar Disorders 2013 updated Bipolar Disorder Guidelines (2013)
Bipolar Disorders, 15 (3), 338-339 - Sleep architecture variation: A mediator of metabolic disturbance in individuals with major depressive disorder (2013)
Sleep Medicine, 14 (10), 943-949 - Systematic review of neurocognition and occupational functioning in major depressive disorder (2013)
Neuropsychiatry, 3 (1), 97-105 - The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM). (2013)
Journal of Affective Disorders, 148 (2-3), 424-430 - The relationship between clinical outcomes and quality of life in first-episode mania: A longitudinal analysis (2013)
Bipolar Disorders, 15 (2), 188-198 - A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression: Clinical article (2012)
Journal of Neurosurgery, 116 (2), 315-322 - Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: A meta-analysis (2012)
Bipolar Disorders, 14 (5), 478-487 - Comparison of neuropsychological effects of adjunctive risperidone or quetiapine in euthymic patients with bipolar i disorder (2012)
International Clinical Psychopharmacology, 27 (2), 91-99 - Deep brain stimulation interruption and suicidality (2012)
Journal of Neurosurgery, 116 (2), 467-468 - Direct health care costs of treating seasonal affective disorder: A comparison of light therapy and fluoxetine (2012)
Depression Research and Treatment, 2012 - Onset, time course and trajectories of improvement with antidepressants (2012)
European Neuropsychopharmacology, 22 (SUPPL) - Positron emission tomography study of the effects of tryptophan depletion on brain serotonin 2 receptors in subjects recently remitted from major depression (2012)
Archives of General Psychiatry, 69 (6), 601-609 - Seasonal Affective Disorders (2012)
Issues in Mental Health Nursing, - Selective-serotonin reuptake inhibitors (2012)
Antidepressants and Major Depressive Disorder, , 13-25 - The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction (2012)
Current Pharmaceutical Design, - The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention-deficit/hyperactivity disorder (2012)
Annals of Clinical Psychiatry, 24 (1), 23-37 - The prevalence and impact of depression in self-referred clients attending an employee assistance program (2012)
Journal of Occupational and Environmental Medicine, 54 (11), 1395-1399 - Which depressive symptoms and medication side effects are perceived by patients as interfering most with occupational functioning? (2012)
Depression Research and Treatment, 2012 - Why are there no treatment guidelines for mood disorders and comorbidities? (2012)
Annals of Clinical Psychiatry, 24 (1), 4-5 - Adjunctive Medication Strategies for Treatment -Resistant Depression (2011)
Canadian Journal of Psychiatry, - Clinical effectiveness: The importance of psychosocial functioning outcomes (2011)
Journal of Affective Disorders, 132 (SUPPL) - Comparative efficacy of escitalopram in the treatment of major depressive disorder (2011)
Neuropsychiatric Disease and Treatment, 7 (1), 39-49 - Do symptoms of bipolar disorder exhibit seasonal variation? A multisite prospective investigation (2011)
Bipolar Disorders, 13 (7-8), 687-695 - Evaluation of a disease-management intervention designed to reduce depression disability (2011)
Journal of Evaluation in Clinical Practice, 17 (2), 322-325 - Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar i disorder (2011)
Psychological Medicine, 41 (5), 971-982 - Telephone-administered cognitive-behavioral therapy for clients with depressive symptoms in an employee assistance program: A pilot study (2011)
Annals of Clinical Psychiatry, 23 (1), 11-16 - The association of elevated body mass index with reduced brain volumes in first-episode mania (2011)
Biological Psychiatry, 70 (4), 381-387 - A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosa (2010)
Neuropsychopharmacology, 35 (8), 1729-1733 - Brain serotonin-2 receptors in acute mania (2010)
British Journal of Psychiatry, 196 (1), 47-51 - Divalproex sodium versus placebo in the treatment of acute bipolar depression: A systematic review and meta-analysis (2010)
Journal of Affective Disorders, 124 (3), 228-234 - Effect of electroconvulsive therapy on brain 5-HT2 receptors in major depression (2010)
British Journal of Psychiatry, 196 (6), 474-479 - Efficacy and tolerability of extended release quetiapine fumarate monotherapy as maintenance treatment of major depressive disorder: A randomized, placebo-controlled trial (2010)
Depression and Anxiety, 27 (10), 964-976 - Escitalopram versus serotonin noradrenaline reuptake inhibitors as second step treatment for patients with major depressive disorder: A pooled analysis (2010)
International Clinical Psychopharmacology, 25 (4), 199-203 - Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode (2010)
Journal of Clinical Psychiatry, 71 (9), 1234-1242 - Relief of Chronic or Resistant Depression (Re-ChORD): A pragmatic, randomized, open-treatment trial of an integrative program intervention for chronic depression (2010)
Journal of Affective Disorders, 123 (1-3), 243-248 - The association of weight gain with mood symptoms and functional outcomes following a first manic episode: Prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2010)
Bipolar Disorders, 12 (6), 616-626 - The importance of early symptom relief in antidepressant treatment: focus on agomelatine (2010)
Journal of Psychopharmacology, - Weight gain, obesity, and metabolic indices following a first manic episode: Prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM) (2010)
Journal of Affective Disorders, 124 (1-2), 108-117 - A new clinical rating scale for work absence and productivity: Validation in patients with major depressive disorder (2009)
BMC Psychiatry, 9 - Accelerated age-related decrease in brain-derived neurotrophic factor levels in bipolar disorder (2009)
International Journal of Neuropsychopharmacology, 12 (1), 137-139 - Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder (2009)
International Journal of Neuropsychopharmacology, 12 (4), 447-458 - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults (2009)
Journal of Affective Disorders, 117 (SUPPL) - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical Guidelines for the Management of Major Depressive Disorder in Adults. I. Classification, Burden and Principles of Management (2009)
Journal of Affective Disorders, 117 (SUPPL) - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medication (2009)
Journal of Affective Disorders, 117 (SUPPL) - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy (2009)
Journal of Affective Disorders, 117 (SUPPL) - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies (2009)
Journal of Affective Disorders, 117 (SUPPL) - Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. V. Complementary and alternative medicine treatments (2009)
Journal of Affective Disorders, 117 (SUPPL) - Course and Outcome after the First Manic Episode in Patients with Bipolar Disorder: Prospective 12-Month Data from the Systematic Treatment Optimization Program for Early Mania Project (2009)
Canadian Journal of Psychiatry, - Evidence of a Biological Effect of Light Therapy on the Retina of Patients with Seasonal Affective Disorder (2009)
Biological Psychiatry, 66 (3), 253-258 - Functional outcomes in first-episode patients with bipolar disorder: a prospective study from the Systematic Treatment Optimization Program for Early Mania project (2009)
Comprehensive Psychiatry, 50 (1), 1-8 - Review: High frequency repetitive transcranial magnetic stimulation improves symptoms of treatment resistant major depression (2009)
Evidence-Based Mental Health, 12 (3) - Addressing circadian rhythm disturbances in depressed patients (2008)
Journal of Psychopharmacology, - Antidepressant-Associated Mood Elevations in Bipolar II Disorder Compared With Bipolar I Disorder and Major Depressive Disorder: A Systematic Review and Meta-Analysis (2008)
Journal of Clinical Psychiatry, - Burden of bipolar depression: Impact of disorder and medications on quality of life (2008)
CNS Drugs, 22 (5), 389-406 - Escitalopram and duloxetine in the treatment of major depressive disorder: A pooled analysis of two trials (2008)
International Clinical Psychopharmacology, 23 (4), 181-187 - Repetitive transcranial magnetic stimulation for treatment-resistant depression: A systematic review and metaanalysis (2008)
Canadian Journal of Psychiatry, 53 (9), 621-631 - A controlled trial of the litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) (2007)
BMC Psychiatry, 7 - A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania (2007)
Bipolar Disorders, 9 (7), 693-697 - A pilot study of adherence with light treatment for seasonal affective disorder (2007)
Psychiatry Research, 149 (1-3), 315-320 - Efficacy, effectiveness and efficiency of escitalopram in the treatment of major depressive and anxiety disorders (2007)
Expert Review of Pharmacoeconomics and Outcomes Research, 7 (6), 559-576 - High-quality remission: Potential benefits of the melatonergic approach for patients with major depressive disorder (2007)
International Clinical Psychopharmacology, 22 (SUPPL) - Long-Term and Preventative Treatment for Seasonal Affective Disorder (2007)
CNS Drugs, - Psychosocial outcomes following electroconvulsive therapy in a community setting: Retrospective chart review with 2-year follow-up (2007)
Canadian Journal of Psychiatry, 52 (9), 598-604 - Quality of life as an outcome indicator in patients with seasonal affective disorder: Results from the Can-SAD study (2007)
Psychological Medicine, 37 (5), 727-736 - Quality of life impairment in bipolar disorder (2007)
Quality of Life Impairment in Schizophrenia, Mood and Anxiety Disorders: New Perspectives on Research and Treatment, , 253-274 - Seasonal affective disorder: A clinical update (2007)
Annals of Clinical Psychiatry, 19 (4), 239-246 - The impact of bipolar disorder upon work functioning: A qualitative analysis (2007)
Bipolar Disorders, 9 (1-2), 129-143 - Which antidepressants have demonstrated superior efficacy? A review of the evidence (2007)
International Clinical Psychopharmacology, 22 (6), 323-329 - A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype Hypothesis (2006)
Neuropsychopharmacology, 31 (11), 2498-2503 - Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis? (2006)
Journal of Psychiatry and Neuroscience, 31 (2), 84-92 - Bipolar disorder and quality of life: A patient-centered perspective (2006)
Quality of Life Research, 15 (1), 25-37 - Challenges in the treatment of anxiety disorders: Beyond guidelines (2006)
International Journal of Psychiatry in Clinical Practice, 10 (SUPPL), 18-24 - Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: A meta-analysis (2006)
Journal of Psychiatry and Neuroscience, 31 (2), 122-131 - Erratum: A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis (Neuropsychopharmacology (2006) 31, (2498-2503) DOI: 10.1038/sj.npp.1301121 (2006)
Neuropsychopharmacology, 31 (11) - Erratum: Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: A meta-analysis (Journal of Psychiatry and Neuroscience (2006) 31, 2 (122-131)) (2006)
Journal of Psychiatry and Neuroscience, 31 (4) - Generalized anxiety disorder: How to treat, and for how long? (2006)
International Journal of Psychiatry in Clinical Practice, 10 (SUPPL), 10-15 - International Journal of Psychiatry in Clinical Practice: Editorial (2006)
International Journal of Psychiatry in Clinical Practice, 10 (SUPPL) - O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep (2006)
Journal of Affective Disorders, 90 (2-3), 227-231 - Personality and seasonal affective disorder: Results from the CAN-SAD study (2006)
Journal of Affective Disorders, 93 (1-3), 35-42 - Sleep disturbances and depression: A challenge for antidepressants (2006)
International Clinical Psychopharmacology, 21 (SUPPL) - The can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder (2006)
American Journal of Psychiatry, 163 (5), 805-812 - The influence of baseline severity on efficacy of escitalopram and citalopram in the treatment of major depressive disorder: An extended analysis (2006)
Pharmacopsychiatry, 39 (5), 180-184 - The relevance of an employee assistance program to the treatment of workplace depression (2006)
Journal of Workplace Behavioral Health, 21 (1), 67-77 - A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania (2005)
Bipolar Disorders, Supplement, 7 (5), 53-57 - Chronotherapeutics (light and wake therapy) in affective disorders (2005)
Psychological Medicine, 35 (7), 939-944 - Oxcarbazepine add-on in the treatment of refractory bipolar disorder (2005)
Bipolar Disorders, Supplement, 7 (5), 37-42 - Quality of life in bipolar disorder: A review of the literature (2005)
Health and Quality of Life Outcomes, 3 - Therapeutic mechanism in seasonal affective disorder: Do fluoxetine and light operate through advancing circadian phase? (2005)
Chronobiology International, 22 (5), 937-943 - Update on the biology of seasonal affective disorder (2005)
CNS Spectrums, 10 (8), 635-646 - A comparison of personality function among patients with seasonal depression, nonseasonal depression, and nonclinical participants (2004)
Journal of Personality Disorders, 18 (5), 448-458 - Brightening depression (2004)
Science, - Brightening Depression [1] (2004)
Science, 303 (5657), 467-469 - Childhood Inattention and Dysphoria and Adult Obesity Associated with the Dopamine D4 receptor Gene in Overeating Women with Seasonal Affective Disorder (2004)
Neuropsychopharmacology, 29 (1), 179-186 - Citalopram and bupropion-SR: Combining versus switching in patients with treatment-resistant depression (2004)
Journal of Clinical Psychiatry, 65 (3), 337-340 - Does neuroimmune dysfunction mediate seasonal mood changes in winter depression? (2004)
Medical Hypotheses, 63 (4), 567-573 - Electroretinography in patients with winter seasonal affective disorder (2004)
Psychiatry Research, 127 (1-2), 27-34 - Evidence-Based Strategies for Achieving and Sustaining Full Remission in Depression: Focus on Metaanalyses (2004)
Canadian Journal of Psychiatry, 49 (3 SUP) - Generic and health-related quality of life in patients with seasonal and nonseasonal depression (2004)
Psychiatry Research, 128 (3), 245-251 - Is remission of depressive symptoms in primary care a realistic goal? A meta-analysis (2004)
BMC Family Practice, 5 - Priorities in treating depression only (2004)
International Journal of Psychiatry in Clinical Practice, 8 (SUPPL), 25-29 - Proceedings from two satellite symposia presented at the 16th Congress of the European College of Neuropsychopharmacology, Prague, September 2003: Editorial (2004)
International Journal of Psychiatry in Clinical Practice, 8 (SUPPL) - The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: An evolutionary perspective (2004)
Biological Psychiatry, 56 (9), 665-669 - Treatment of seasonal affective disorder: Unipolar versus bipolar differences (2004)
Current Psychiatry Reports, 6 (6), 478-485 - Advances in treatment of mood and anxiety disorders: Focus on atypical antipsychotics (2003)
Bipolar Disorders, Supplement, 5 (2), 5-6 - Clinical guidelines for depressive disorders - Summary of recommendations relevant to family physicians (2003)
Canadian Family Physician, - Enhancing outcomes in the management of treatment resistant depression: A focus on atypical antipsychotics (2003)
Bipolar Disorders, Supplement, 5 (2), 36-47 - Letter to the editor (multiple letters) [1] (2003)
Psychological Medicine, 33 (6), 1133-1135 - Mirtazapine for treatment-resistant depression: A preliminary report (2003)
Journal of Psychiatry and Neuroscience, 28 (1), 55-59 - Recent developments in the psychobiology and pharmacotherapy of depression: Optimising existing treatments and novel approaches for the future (2003)
Expert Opinion on Investigational Drugs, 12 (1), 65-86 - Review: Antidepressants and psychotherapy may be equally effective for promoting remission in major depressive disorder: Commentary (2003)
Evidence-Based Mental Health, 6 (2) - The Interpersonal Expression of Perfection: Perfectionistic Self-presentation and Psychological Distress (2003)
Journal of Personality and Social Psychology, 84 (6), 1303-1325 - The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality (2003)
Psychological Medicine, 33 (5), 785-792 - Where is the primary care viewpoint? (multiple letters) [2] (2003)
Canadian Family Physician, 49 (AUG.), 960-962 - A comparison of open treatment of seasonal major and minor depression with light therapy (2002)
Journal of Affective Disorders, 71 (1-3), 243-248 - Bipolar spectrum disorders - New perspectives (2002)
Canadian Family Physician, - Combining antidepressants for treatment-resistant depression: A review (2002)
Journal of Clinical Psychiatry, 63 (8), 685-693 - Evidence supports validity of seasonal affective disorder (2002)
Canadian Journal of Psychiatry, - Evidence supports validity of seasonal affective disorder [2] (multiple letters) (2002)
Canadian Journal of Psychiatry, 47 (8), 786-787 - PET study of [18F]6-fluoro-L-dopa uptake in neuroleptic and mood-stabilizer-naive first-episode nonpsychotic mania: Effects of treatment with divalproex sodium (2002)
American Journal of Psychiatry, 159 (5), 768-774 - PET study of the effects of valproate on dopamine D2 receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania (2002)
American Journal of Psychiatry, 159 (10), 1718-1723 - Pharmacotherapy to sustain the fully remitted state (2002)
Journal of Psychiatry and Neuroscience, 27 (4), 269-280 - Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder (2002)
Journal of Affective Disorders, 71 (1-3), 229-233 - Reboxetine: A preliminary report on its use through the Special Access Program (2002)
Journal of Psychiatry and Neuroscience, 27 (6), 418-422 - Seasonal affective disorder: The latitude hypothesis revisited (2002)
Canadian Journal of Psychiatry, - Seasonal affective disorder: The latitude hypothesis revisited [3] (2002)
Canadian Journal of Psychiatry, 47 (8), 787-788 - Short-term dynamic psychotherapies in the treatment of major depression [1] (multiple letters) (2002)
Canadian Journal of Psychiatry, 47 (2), 193-194 - An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa (2001)
Journal of Clinical Psychiatry, 62 (3), 164-168 - Clinical guidelines for the treatment of depressive disorders I. Definitions, prevalence, and health burden (2001)
Canadian Journal of Psychiatry, - Clinical guidelines for the treatment of depressive disorders II. Principles of management (2001)
Canadian Journal of Psychiatry, - Clinical guidelines for the treatment of depressive disorders III. Psychotherapy (2001)
Canadian Journal of Psychiatry, - Clinical guidelines for the treatment of depressive disorders IV. Medications and other biological treatments (2001)
Canadian Journal of Psychiatry, - Clinical guidelines for the treatment of depressive disorders. I. Definitions, prevalence and health effects | Lignes directrices cliniques du traitement des troubles dépressifs. I. Définitions, prévalence et répercussions sanitaires (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. II. Management principles | Lignes directrices cliniques du traitement des troubles dépressifs. II. Principes de la prise en charge (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. III. Psychotherapy | Lignes directrices cliniques du traitement des troubles dépressifs. III. Psychothérapie (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. IV. Pharmacotheraphy and other biological treatments | Lignes directrices cliniques du traitement des troubles dépressifs. IV. Pharmacothérapie et autres traitements biologiques (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. V. Combination of psychotherapy and pharmacotherapy | Lignes directrices cliniques du traitement des troubles dépressifs. V. Combinaison de la psychothérapie et de la pharmacothérapie (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. VI. Specific populations | Lignes directrices cliniques du traitement des troubles dépressifs. VI. Populations particulières (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Clinical guidelines for the treatment of depressive disorders. VII. Comorbidity | Lignes directrices cliniques du traitement des troubles dépressifs. VII. Comorbidité (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Comorbidity (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania (2001)
Journal of Clinical Psychiatry, 62 (12), 975-980 - Definitions, prevalence, and health burden (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission (2001)
Neuropsychopharmacology, 25 (5 SUP) - Effects of rapid tryptophan depletion on brain 5-HT2 receptors: A PET study (2001)
British Journal of Psychiatry, 178 (MAY), 448-453 - Immune-inflammatory markers in patients with seasonal affective disorder: Effects of light therapy (2001)
Journal of Affective Disorders, 63 (1-3), 27-34 - Medications and other biological treatments (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Patients' preferences and counselling for depression in primary care (2001)
Lancet, 357 (9256), 575-576 - Principles of management (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Psychotherapy (2001)
Canadian Journal of Psychiatry, 46 (SUPPL) - Seasonal depression: The dual vulnerability hypothesis revisited (2001)
Journal of Affective Disorders, 63 (1-3), 123-132 - A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans (2000)
Psychopharmacology, 151 (4), 424-427 - Brain serotonin(2) receptors in major depression - A positron emission tomography study (2000)
Archives of General Psychiatry, - Brain serotonin2 receptors in major depression: A positron emission tomography study (2000)
Archives of General Psychiatry, 57 (9), 850-858 - Does the addition of pindolol accelerate the response to electroconvulsive therapy in patients with major depression? A double-blind, placebo-controlled pilot study (2000)
Journal of Clinical Psychopharmacology, 20 (3), 373-378 - Effects of light therapy on suicidal ideation in patients with winter depression (2000)
Journal of Clinical Psychiatry, 61 (1), 30-32 - Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission (2000)
Psychological Medicine, 30 (1), 79-87 - Erratum: Growth hormone to baclofen in patients with seasonal affective disorder: Effects of light therapy (Psychoneuroendocrinology (1999) 54:2 (143-153) PII: S0306453098000663) (2000)
Psychoneuroendocrinology, 25 (3) - Pathophysiology of seasonal affective disorder: A review (2000)
Journal of Psychiatry and Neuroscience, 25 (5), 469-480 - Review: Lithium augmentation increases treatment response in refractory depression: Commentary (2000)
Evidence-Based Mental Health, 3 (2) - A controlled study of light therapy in women with late luteal phase dysphoric disorder (1999)
Psychiatry Research, 86 (3), 185-192 - Adverse effects of pindolol augmentation in patients with bipolar depression [6] (1999)
Journal of Clinical Psychopharmacology, 19 (4), 383-384 - Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: A positron emission tomography study with fluorine-18-labeled setoperone (1999)
Archives of General Psychiatry, 56 (8), 705-711 - Growth hormone response to baclofen in patients with mania: A pilot study (1999)
Psychopharmacology, 147 (3), 280-284 - Growth hormone response to baclofen in patients with seasonal affective disorder: Effects of light therapy (1999)
Psychoneuroendocrinology, 24 (2), 143-153 - Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls (1999)
Journal of Affective Disorders, 54 (3), 295-301 - A Canadian multicenter study of three fixed doses of controlled-release ipsapirone in outpatients with moderate to severe major depression (1998)
Journal of Clinical Psychopharmacology, 18 (4), 268-273 - Cortisol, hypothermic, and behavioral responses to ipsapirone in patients with bipolar depression and normal controls (1998)
Neuropsychobiology, 38 (1), 6-12 - Divalproex sodium attenuates growth hormone response to baclofen in healthy human males (1998)
Neuropsychopharmacology, 18 (5), 370-376 - Effects of lamotrigine on the 5-HT(1A) receptor function in healthy human males (1998)
Journal of Affective Disorders, 49 (2), 157-162 - Manic reaction after induction of ovulation with gonadotropins [2] (1998)
American Journal of Psychiatry, 155 (3), 447-448 - Seasonal affective disorder: Diagnosis and management (1998)
Primary Care Psychiatry, 4 (2), 63-74 - Seasonal mood change and personality: An investigation of genetic co- morbidity (1998)
Psychiatry Research, 78 (1-2), 1-7 - Atypical depressive symptoms in seasonal and non-seasonal mood disorders (1997)
Journal of Affective Disorders, 44 (1), 39-44 - Effects of chronic lithium treatment on retinal electrophysiologic function (1997)
Biological Psychiatry, 41 (6), 737-742 - Effects of divalproex sodium on 5-HT(1A) receptor function in healthy human males: Hypothermic, hormonal, and behavioral responses to ipsapirone (1997)
Neuropsychopharmacology, 17 (6), 382-390 - Gender differences in the heritability of seasonal mood change (1997)
Psychiatry Research, 70 (3), 145-154 - Growth hormone response to sumatriptan (5-HT1D agonist) challenge in seasonal affective disorder: Effects of light therapy (1997)
Biological Psychiatry, 42 (1), 24-29 - Light therapy for depressive disorders: Indications and efficacy (1997)
Modern Problems of Pharmacopsychiatry, 25, 215-234 - Mania, Depression, and Mood Dependent Memory (1997)
Cognition and Emotion, 11 (5-6), 607-618 - Seasonality of symptoms in women with late luteal phase dysphoric disorder (1997)
American Journal of Psychiatry, 154 (10), 1436-1441 - Sumatriptan-induced growth hormone release in patients with major depression, mania, and normal controls (1997)
Neuropsychopharmacology, 17 (4), 258-263 - The relationship between seasonal mood change and personality: More apparent than real? (1997)
Acta Psychiatrica Scandinavica, 95 (6), 539-543 - Atypical depressive symptoms and clusters in unipolar and bipolar depression (1996)
Acta Psychiatrica Scandinavica, 94 (6), 421-427 - Effect of stimulus intensity on prolactin and cortisol release induced by unilateral electroconvulsive therapy (1996)
Neuropsychopharmacology, 15 (3), 263-270 - Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy (1996)
Archives of General Psychiatry, - Major Depression, Minor Depression, and Double Depression: Are They Distinct Clinical Entities? (1996)
American Journal of Medical Genetics - Seminars in Medical Genetics, 67 (4), 347-353 - Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: A study with ondansetron (1996)
Psychiatry Research, 60 (1), 33-39 - Seasonality of symptoms in anorexia and bulimia nervosa (1996)
International Journal of Eating Disorders, 19 (1), 35-44 - The validity of atypical depression in DSM-IV (1996)
Comprehensive Psychiatry, 37 (6), 375-383 - Treatment of SAD - Reply (1996)
Canadian Journal of Psychiatry, - MULTICENTER, PLACEBO-CONTROLLED STUDY OF FLUOXETINE IN SEASONAL AFFECTIVE-DISORDER (1995)
American Journal of Psychiatry, - Prolactin response to buspirone challenge in the presence of dopaminergic blockade (1995)
Biological Psychiatry, 38 (4), 235-239 - A CONTROLLED-STUDY OF LIGHT THERAPY FOR BULIMIA-NERVOSA (1994)
American Journal of Psychiatry, - MANIA PRECIPITATED BY LIGHT THERAPY FOR PATIENTS WITH SAD (1994)
Journal of Clinical Psychiatry, - Mania precipitated by light therapy for patients with SAD [1] (1994)
Journal of Clinical Psychiatry, 55 (10) - Mood disorder service genetic database: Morbidity risks for mood disorders in 3,942 first-degree relatives of 671 index cases with single depression, recurrent depression, bipolar I, or bipolar II (1994)
American Journal of Medical Genetics, 54 (2), 132-140 - Morning light therapy for winter depression: Predictors of response (1994)
Acta Psychiatrica Scandinavica, 89 (2), 97-101 - RESEARCH FUNDING OF PSYCHIATRIC-DISORDERS IN CANADA - A SNAPSHOT, 1990-1991 (1994)
Canadian Journal of Psychiatry, - Comparison of fluoxetine and desipramine in depressed outpatients (1993)
Current Therapeutic Research - Clinical and Experimental, 53 (5), 457-465 - Depressive symptoms and family history in seasonal and nonseasonal mood disorders (1993)
American Journal of Psychiatry, 150 (3), 443-448 - Eating attitudes in seasonal affective disorder and bulimia nervosa (1993)
Journal of Affective Disorders, 29 (4), 219-225 - EFFECT OF STIMULUS ENERGY ON ELECTROCONVULSIVE THERAPY-INDUCED PROLACTIN-RELEASE (1993)
Convulsive Therapy, - Increased plasma concentration of imipramine following augmentation with fluvoxamine [11] (1993)
American Journal of Psychiatry, 150 (10) - INCREASED PLASMA-CONCENTRATION OF IMIPRAMINE FOLLOWING AUGMENTATION WITH FLUVOXAMINE (1993)
American Journal of Psychiatry, - Light visor treatment for seasonal affective disorder: A multicenter study (1993)
Psychiatry Research, 46 (1), 29-39 - SIDE-EFFECTS OF LIGHT THERAPY IN SEASONAL AFFECTIVE-DISORDER (1993)
American Journal of Psychiatry, - Antidepressants: Which to use first? [3] (1992)
Canadian Journal of Psychiatry, 37 (8) - Electroretinography in seasonal affective disorder (1992)
Psychiatry Research, 43 (1), 55-63 - Hypersomnia and morning light therapy for winter depression (1992)
Biological Psychiatry, 31 (10), 1062-1064 - The effects of ultraviolet-A wavelengths in light therapy for seasonal depression (1992)
Journal of Affective Disorders, 24 (4), 237-243 - THE ROLE OF DOPAMINE IN SEIZURE-INDUCED PROLACTIN-RELEASE IN HUMANS (1992)
Convulsive Therapy, - Winter seasonal affective disorder [20] (1992)
American Journal of Psychiatry, 149 (6), 852-853 - ECT-induced prolactin release: Effect of sex, electrode placement and serotonin uptake inhibition (1991)
Human Psychopharmacology: Clinical and Experimental, - LOW ELECTROOCULOGRAPHIC RATIOS IN PATIENTS WITH SEASONAL AFFECTIVE-DISORDER (1991)
American Journal of Psychiatry, - Request for more information about study of rapid cycling in affective disorders [18] (1991)
American Journal of Psychiatry, 148 (8), 1098-1099 - SEASONAL AFFECTIVE-DISORDER PRESENTING AS CHRONIC FATIGUE SYNDROME (1991)
Canadian Journal of Psychiatry, - Seasonal mood symptoms in bulimia nervosa and seasonal affective disorder (1991)
Comprehensive Psychiatry, 32 (6), 552-558 - ULTRAVIOLET VERSUS NON-ULTRAVIOLET LIGHT THERAPY FOR SEASONAL AFFECTIVE-DISORDER (1991)
Journal of Clinical Psychiatry, - A PSYCHIATRIC FELLOWSHIP IN THE UNITED-STATES (1990)
Canadian Journal of Psychiatry, - Melatonin suppression in bipolar and unipolar mood disorders (1990)
Psychiatry Research, 33 (2), 129-134 - SEASONAL AFFECTIVE-DISORDER (1990)
Canadian Family Physician, - TREATMENT OF DEPRESSION IN PATIENTS WITH DEMENTIA (1990)
American Journal of Psychiatry, - Light therapy for seasonal bulimia (1989)
American Journal of Psychiatry, 146 (12), 1640-1641 - PHOTOTHERAPY FOR DEPRESSIVE-DISORDERS - A REVIEW (1989)
Canadian Journal of Psychiatry, - Seasonal affective disorder- a Canadian sample (1989)
Annals of Clinical Psychiatry, 1 (4), 241-245 - Antidepressant Drug Studies in the Elderly (1988)
The Psychiatric Clinics of North America, - ECT in the treatment of mixed depression and dementia (1988)
British Journal of Psychiatry, 152 (FEB.), 281-284 - PREVENTING NEUROLEPTIC-INDUCED TARDIVE DYSKINESIA IN ADULTS AND CHILDREN (1988)
L'Encephale, - PSYCHIATRIC MORBIDITY ASSOCIATED WITH EARLY CLINICAL-DIAGNOSIS OF HUNTINGTON DISEASE IN A PREDICTIVE TESTING PROGRAM (1988)
Journal of Clinical Psychiatry, - The Clinical Use of EEG in a General Psychiatric Setting (1988)
Hospital & Community Psychiatry, - THE LATERALIZATION OF ATYPICAL FACIAL-PAIN (1988)
Canadian Journal of Psychiatry, - ALPRAZOLAM-INDUCED MANIC SWITCH (1985)
Journal of Clinical Psychiatry, 46 (9), 406-407 - Pigmentary retinopathy associated with low-dose thioridazine treatment. (1985)
Canadian Medical Association journal, 132 (7)
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