Najib Ayas

Associate Professor

Relevant Degree Programs


Graduate Student Supervision

Doctoral Student Supervision (Jan 2008 - Nov 2019)
Endothelial dysfunction in mice subjected to intermittent hypoxia and fed a high fat diet (2019)

No abstract available.

Renal injury in a mouse model of sleep apnea is prevented by alpha-lipoic acid through reduced oxidative stress and inflammation (2019)

The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.

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The impact of obstructive sleep apnea on occupational injuries (2019)

Background: Obstructive Sleep Apnea (OSA) is a common but under diagnosed respiratory disorder characterized by recurrent upper airway obstruction during sleep. OSA results in sleep fragmentation and hypoxemia and is associated with neurocognitive impairments. OSA negatively affects vigilance and work performance, yet there is limited evidence on the relationship between OSA and the risk of occupational injuries (OI). It is hypothesized that individuals with OSA would have an increased risk of OI, and that OSA treatment may reduce this risk. Dissertation Objectives:1. Summarize the existing evidence on the relationship between OSA and OI (Chapter 1).2. Evaluate the association between the presence and severity of OSA and the risk of OI, both before and after diagnosis (Chapters 2-4). 3. Evaluate the impact of Continuous Positive Airway Pressure (CPAP) treatment on the risk of OI (Chapter 5).Methods: Patients referred to the UBC Sleep Disorders Clinic (SDC) for suspected OSA (2003-2011) were recruited to participate and diagnosed with OSA using polysomnography (PSG). Rates and risk of OI in the five years pre and post-PSG were calculated and compared by OSA status by linking to workers claims data. In addition, a matched sample of residents linked to claims data was drawn from the provincial health registry and compared to the OSA group. CPAP adherence data was collected from all OSA patients whose charts were available, and the impact of CPAP on the risk of OI was assessed using a pre/post treatment design.

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Membership Status

Member of G+PS
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