Kelly Turner
Master of Science in Medical Genetics (MSc)
Research Topic
Targeting the Hedgehog Pathway in Chronic Myeloid Leukemia Stem Cells with a Novel Combination Therapy
Xiaoyan Jiang
Professor
Research Classification
Cancer Genetics
Cell Signaling and Cancer
Leukemia
Cancer Diagnosis and Detection
Research Interests
Basic and translational leukemia research
Leukemic stem cell biology
Gene regulation
Drug resistance
Proteomics
Relevant Degree Programs
Recruitment
Master's students
Doctoral students
Postdoctoral Fellows
Outstanding candidates can expect a full funding package offer
Any time / year round
The overall goal of my research program is to understand the molecular mechanisms and cellular functions of specific oncogenes, tumor suppressor genes, miRNAs and their target genes in the regulation of the properties of cancer/leukemic stem cells, signal transduction events, initiation and progression of human leukemia and drug resistance. The ultimate objective is to identify molecules and pathways that will lead to new, rationally designed, more effective, and less toxic, personalized molecularly targeted therapies. In particular, we are extremely interested in developing mechanism-based combination therapeutic strategies that can directly target drug-insensitive leukemic stem cells.
Graduate Student Supervision
Doctoral Student Supervision (since 2008)
- Functional and structural study of the AHI-1 SH3 domain, characterization of the BCR-ABL-AHI-1-Dynamin-2 protein complex and investigation of oncogenic roles of dynamin-2 in chronic myeloid leukemia (2017)
- Characterization of novel therapeutic targets in chronic myeloid leukemia (2016)
- Clinical application and functional characterization of TOX in cutaneous T-cell lymphoma (2016)
- Identification and characterization of novel therapeutic targets and biomarkers in chronic myeloid leukemia (2016)
- The role of BIN1 in the regulation of cell proliferation, apoptosis and tumor formation in cutaneous T-cell lymphoma (2014)
Master's Student Supervision (2012-2016)
- Targeting Tyrosine Kinase Inhibitor-Insensitive Stem/Progenitor Cells by Effective Inhibition of a Novel PP2A-AHI-1-BCR-ABL-JAK2 Complex (2015)
- An investigation into the role of C-terminal tensin-like protein (Cten) in melanomagenesis (2013)
Current Students & Alumni
This is a small sample of students and/or alumni that have been supervised by this researcher. It is not meant as a comprehensive list.
Membership Status
Full member in G+PS
Program Affiliations
Department(s)
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