Yanqi Liu

 
Brian MacVicar
Toronto
Canada
 

Research Topic

The role of SLC26A11 chloride channel in neuronal swelling associated with spreading depolarizaiton

Research Description

Cortical spreading depression (CSD) is a transient wave of neuronal depolarization propagating across the neocortex followed by periods of electrical silence. CSD is implicated in neurological diseases such as stroke, traumatic brain injury, and migraine aura. During CSD, morphological changes of neurons include swelling of the soma and dendritic beading (“bead on a string” appearance). A previous study in the lab identified a chloride channel, SLC26A11, as an essential component mediating neuronal swelling during cytotoxic edema (Rungta et al (2015) Cell). In addition, this channel was observed to be activated at depolarizing potentials. Given that CSD also involves neuronal depolarization and neuronal swelling, the aim of this study is to investigate the role of the SLC26A11 channel in neuronal swelling during CSD and its contribution to other features of CSD.

Why did you decide to study at UBC?

UBC houses many labs of expertise in a particular field of neuroscience. It has a beautiful campus and possesses great facilities. In addition, Vancouver is a perfect out-door orientated city.

 

Why did you decide to pursue a graduate degree?

Throughout my undergraduate career in the life science program, I had came across many exposures to the research field. I am amazed by the flow of logic during experiment design and the meticulousness required to be a good scientist. I am also curious about the biology of the brain on how it is capable of mediating many very complex processes. Graduate school is the best choice for me in order to develop such logical mind set and full fill my curiosity.