Karolin Heinze
Postdoctoral Fellow
I study the regulatory landscape in different histological types of ovarian cancer, determine gene expression in different tumor compartments and the interactions within the surrounding microenvironment, mainly facilitated through RNA and WholeGenome Methylation sequencing. Furthermore, I am interested in biomarker discovery for early detection and disease progression monitoring in specifically endometriosis-associated ovarian cancer and endometriosis.
Supervisor
Research Classification
Research Interests
Cancer biology
Biomarker Discovery
Immunology
Epigentics
Research Methodology
NGS (RNAseq, WGseq)
Exosomes
molecular biology
Histology
laser capture microdissection
multicolor immunohistochemistry
bioinformatics
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
Publications
- Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8 + TIL infiltration, and provides no independent prognostic value in endometriosis‐associated ovarian carcinomas (2022)
The Journal of Pathology, - RUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis (2021)
Cancers, - CAMK2N1/RUNX3 methylation is an independent prognostic biomarker for progression-free and overall survival of platinum-sensitive epithelial ovarian cancer patients (2021)
Clinical Epigenetics, 13 (1) - Prognostic and Immunological Significance of ARID1A Status in Endometriosis-Associated Ovarian Carcinoma (2021)
- Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants (2018)
International Journal of Molecular Sciences, 19 (1), 253
If this is your researcher profile you can log in to the Faculty & Staff portal to update your details.