Michael Hughes
Research Classification
Research Interests
Cell Trafficking
Metastasis
Immunotherapy
Nephrotic Syndrome
Vascular Permeability
Hematopoietic Stem Cell Transplant
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in working with undergraduate students on research projects.
Research Methodology
animal models of disease (mice)
transplantation
Flow cytometry
Immunoassay
Publications
- Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease (2019)
Scientific Reports, 9 (1) - The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection (2019)
The Journal of Immunology, , ji1900781 - CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy (2016)
PLOS ONE, 11 (6), e0157902 - G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program (2016)
Journal of Experimental Medicine, 213 (7), 1153--1162 - Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation (2014)
J. Clin. Invest., 124 (5), 1945--1955 - The CD34 family as facilitators of hematopoietic progenitor cell migration and chemotaxis (2014)
Experimental Hematology, 42 (8), S49 - Declined presentation (2013)
Experimental Hematology, 41 (8), S37 - SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens (2013)
PLoS Pathog, 9 (8), e1003539 - Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection (2012)
Mucosal Immunol, 5 (5), 535--543 - Podocalyxin is a key regulator of breast cancer progression and metastasis. (2012)
Cancer Research, 72 (24 Su), P1--05--05--P1--05--05 - A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis (2011)
Experimental Hematology, 39 (3), 305--320.e2 - MyD88-Dependent SHIP1 Regulates Proinflammatory Signaling Pathways in Dendritic Cells after Monophosphoryl Lipid A Stimulation of TLR4 (2011)
The Journal of Immunology, 186 (7), 3858--3865 - Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration (2011)
PLoS ONE, 6 (4), e18160 - SHIP Represses Th2 Skewing by Inhibiting IL-4 Production from Basophils (2011)
The Journal of Immunology, 186 (1), 323--332 - Analysis of Tie2 function in mast cells (2010)
Allergy, Asthma & Clinical Immunology, 6 (Suppl), P16 - CD34 Is Required for Infiltration of Eosinophils into the Colon and Pathology Associated with DSS-Induced Ulcerative Colitis (2010)
The American Journal of Pathology, 177 (3), 1244--1254 - CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis (2010)
Allergy, Asthma & Clinical Immunology, 6 (Suppl), P23 - Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery (2009)
Experimental Hematology, 37 (1), 10--18 - Prion Protein Expression and Release by Mast Cells After Activation (2009)
J INFECT DIS, 200 (5), 827--831 - SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo (2009)
The Journal of Immunology, 183 (1), 228--236 - The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta (2009)
Developmental Cell, 17 (4), 505--515 - SHIP Represses the Generation of Alternatively Activated Macrophages (2005)
Immunity, 23 (4), 361--374 - The role of SHIP1 in macrophage programming and activation. (2004)
Biochem. Soc. Trans, 32 (5), 785 - The role of SHIP in cytokine-induced signaling (2003)
Reviews of Physiology, Biochemistry and Pharmacology, , 87--103 - Protein Kinase C- Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation (2002)
Molecular and Cellular Biology, 22 (12), 3970--3980 - SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF- B Activity (2002)
The Journal of Immunology, 168 (9), 4737--4746 - Role of Src homology 2-containing-inositol 5′-phosphatase (SHIP) in mast cells and macrophages (2001)
Biochem. Soc. Trans, 31 (1), 286 - SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation. (2001)
- Regulation of Mast Cell Degranulation by SHIP (2000)
Mast Cells and Basophils, , 169--182 - Thapsigargin-Induced Degranulation of Mast Cells Is Dependent on Transient Activation of Phosphatidylinositol-3 Kinase (2000)
The Journal of Immunology, 165 (1), 124--133 - The tyrosine phosphorylation of ship is regulated by src kinases (2000)
Experimental Hematology, 28 (7), 84 - Ships ahoy (1999)
The International Journal of Biochemistry & Cell Biology, 31 (10), 1007--1010 - SHIP, a new player in cytokine-induced signalling (1997)
Leukemia, 11 (2), 181--184 - The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. (1997)
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