Michael Hughes
Research Classification
Cancer progression and metastasis
Research Interests
Cell Trafficking
Metastasis
Immunotherapy
Nephrotic Syndrome
Vascular Permeability
Hematopoietic Stem Cell Transplant
Research Methodology
animal models of disease (mice)
transplantation
Flow cytometry
Immunoassay
Publications
- CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy (2016)
PLOS ONE, 11 (6), e0157902 - G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program (2016)
Journal of Experimental Medicine, 213 (7), 1153--1162 - Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation (2014)
J. Clin. Invest., 124 (5), 1945--1955 - The CD34 family as facilitators of hematopoietic progenitor cell migration and chemotaxis (2014)
Experimental Hematology, 42 (8), S49 - Declined presentation (2013)
Experimental Hematology, 41 (8), S37 - SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens (2013)
PLoS Pathog, 9 (8), e1003539 - Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection (2012)
Mucosal Immunol, 5 (5), 535--543 - Podocalyxin is a key regulator of breast cancer progression and metastasis. (2012)
Cancer Research, 72 (24 Su), P1--05--05--P1--05--05 - A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis (2011)
Experimental Hematology, 39 (3), 305--320.e2 - MyD88-Dependent SHIP1 Regulates Proinflammatory Signaling Pathways in Dendritic Cells after Monophosphoryl Lipid A Stimulation of TLR4 (2011)
The Journal of Immunology, 186 (7), 3858--3865 - Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration (2011)
PLoS ONE, 6 (4), e18160 - SHIP Represses Th2 Skewing by Inhibiting IL-4 Production from Basophils (2011)
The Journal of Immunology, 186 (1), 323--332 - Analysis of Tie2 function in mast cells (2010)
Allergy, Asthma & Clinical Immunology, 6 (Suppl), P16 - CD34 Is Required for Infiltration of Eosinophils into the Colon and Pathology Associated with DSS-Induced Ulcerative Colitis (2010)
The American Journal of Pathology, 177 (3), 1244--1254 - CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis (2010)
Allergy, Asthma & Clinical Immunology, 6 (Suppl), P23 - Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery (2009)
Experimental Hematology, 37 (1), 10--18 - Prion Protein Expression and Release by Mast Cells After Activation (2009)
J INFECT DIS, 200 (5), 827--831 - SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo (2009)
The Journal of Immunology, 183 (1), 228--236 - The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta (2009)
Developmental Cell, 17 (4), 505--515 - SHIP Represses the Generation of Alternatively Activated Macrophages (2005)
Immunity, 23 (4), 361--374 - The role of SHIP1 in macrophage programming and activation. (2004)
Biochem. Soc. Trans, 32 (5), 785 - The role of SHIP in cytokine-induced signaling (2003)
Reviews of Physiology, Biochemistry and Pharmacology, , 87--103 - Protein Kinase C- Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation (2002)
Molecular and Cellular Biology, 22 (12), 3970--3980 - SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF- B Activity (2002)
The Journal of Immunology, 168 (9), 4737--4746 - Role of Src homology 2-containing-inositol 5′-phosphatase (SHIP) in mast cells and macrophages (2001)
Biochem. Soc. Trans, 31 (1), 286 - SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation. (2001)
- Regulation of Mast Cell Degranulation by SHIP (2000)
Mast Cells and Basophils, , 169--182 - Thapsigargin-Induced Degranulation of Mast Cells Is Dependent on Transient Activation of Phosphatidylinositol-3 Kinase (2000)
The Journal of Immunology, 165 (1), 124--133 - The tyrosine phosphorylation of ship is regulated by src kinases (2000)
Experimental Hematology, 28 (7), 84 - Ships ahoy (1999)
The International Journal of Biochemistry & Cell Biology, 31 (10), 1007--1010 - SHIP, a new player in cytokine-induced signalling (1997)
Leukemia, 11 (2), 181--184 - The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. (1997)
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