Ka-Yee Grace Choi
Postdoctoral Fellow
Using novel peptides as an adjunctive treatment against multi-drug antibiotic resistant organisms.
Supervisor
Research Classification
Cell Signaling and Infectious and Immune Diseases
Immune Mediators: Cytokines and Chemokines
Diseases of the Immune System
Antibiotics and Resistance
Research Interests
Host defence peptides
Multi-drug resistant organisms
Antibiotic resistance
Immune modulation
Chronic respiratory infectious diseases
Cystic fibrosis
Air liquid interface (ALI) model
Research Methodology
Human induced pluripotent stem cells
Chronic mouse lung and sinus infection model
Lung air liquid interface (ALI) model
Research Centres, Clusters, Institutes
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
Publications
- Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides. (2020)
Frontiers in cellular and infection microbiology, - Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13–31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index (2019)
Biomolecules, - Polymorphisms in the P2X7 receptor, and differential expression of Toll-like receptor-mediated cytokines and defensins, in a Canadian Indigenous group. (2019)
Scientific reports, - Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase (2018)
Frontiers in Immunology, 9 - The biochemical signatures of stress: A preliminary analysis of osteocalcin concentrations and macroscopic skeletal changes associated with stress in the 13th - 17th centuries black friars population (2015)
American Journal of Physical Anthropology, 159 (4), 596--606 - Antibacterial Host Defense Peptides (2014)
Encyclopedia of Inflammatory Diseases, , 1--9 - Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation (2014)
Immunology, 143 (1), 68--80 - Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis (2014)
Molecular Immunology, 57 (2), 86--92 - Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation (2012)
Journal of Innate Immunity, - Defining TNF-α and IL-1β induced nascent proteins: Combining bio‐orthogonal non‐canonical amino acid tagging and proteomics (2012)
Journal of Immunological Methods, 382 (1-2), 189--195 - Multiple Immune-Modulatory Functions Of Cathelicidin Host Defense Peptides (2012)
Frontiers in Immunology, 3 - Inflammatory Cytokines IL-32 and IL-17 Have Common Signaling Intermediates despite Differential Dependence on TNF-Receptor 1 (2011)
The Journal of Immunology, 186 (12), 7127--7135 - Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts (2011)
Arthritis Research & Therapy, 13 (4), R129
If this is your researcher profile you can log in to the Faculty & Staff portal to update your details.