My research interests are currently focused around drug metabolism and pharmacokinetics. Our work is primarily focused on the phase II (conjugation) enzymes (particularly UDP-glucuronosyltransferase) with a strong focus on pregnancy and pediatrics. We use a number of lab-based biochemical techniques as well as in silico models to improve our understanding of developmental pharmacology, improve drug/chemical safety, and investigate environmental toxicology and endoctrinology.
I am also interested in the use of in silico modeling techniques to develop protein-level strucutural homology models of the UDP-glucuronosyltransferase 1A6 enzyme to allow us to better understand the residues and features of the protein important in co-substrate and substrate binding, in the absence of a crystal structure. This is an outgrowth of work I did in my previous postdoc position with Dr. Tara Klassen (formerly at the Faculty of Pharmaceutical Sciences at UBC), that used these techniques to model the sodium channel SCN1A, a neuronal channel, that when mutated is known to cause severe epilepsy.
- SCN1A variants from bench to bedside—improved clinical prediction from functional characterization (2020)
- Umbilical cord as an analytical matrix – A technical note (2020)
- Detection of opioids in umbilical cord lysates: an antibody-based rapid screening approach (2018)
Toxicology Mechanisms and Methods, , 1--26
- The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes (2017)
Xenobiotica, 48 (9), 882--890
- Vancomycin 50 mg/mL Suspension in Oral Syrup: Stability in Plastic Bottles and Syringes at 2 Temperatures (2017)
The Canadian Journal of Hospital Pharmacy, 70 (3)
- Molecular characterization of two vitellogenin genes from the tick, Amblyomma hebraeum (Acari: Ixodidae). (2014)
- Molecular characterization of the vitellogenin receptor from the tick, Amblyomma hebraeum (Acari: Ixodidae). (2013)
- The impact of RNA interference of the subolesin and voraxin genes in male Amblyomma hebraeum (Acari: Ixodidae) on female engorgement and oviposition (2009)