Relevant Degree Programs
Graduate Student Supervision
Doctoral Student Supervision (Jan 2008 - Nov 2019)
Lung cancer is one of the most common and deadliest forms of cancer. Squamous cell lung carcinomas (SCC), a common lung cancer subtype, feature a series of identifiable premalignant and early malignant forms that progress sequentially into full-blown tumours. This thesis describes a sophisticated and statistically rigorous analysis of global gene expression profiles taken from samples of several key stages of progression. This dataset was generated using serial analysis of gene expression (SAGE), a powerful transcriptome profiling technique that captures small sequence tags from each transcript in an mRNA population. These tags can then be counted and mapped back to a matching transcript sequence to quantitatively determine the expression of a given gene. The analysis identified several genes which show changes in expression that are highly correlated with the progressive steps of SCC. In addition, gene expression changes were identified in samples of bronchial epithelium that correspond to an acute response to tobacco smoke exposure, a major contributor to SCC development. The use of multiple sample types, the presence of extensive cellular heterogeneity, and the rarity of biological material for the purpose of validation introduced an additional layer of complexity that are not well-suited to conventional methods of SAGE analysis. To address these challenges, this thesis describes the development of two methodological improvements to SAGE data analysis. The first describes a computational strategy to identify additional sequence information that effectively increases the length of SAGE tag sequences, greatly enhancing the fidelity of tag to gene mapping. The second describes a new statistical method that shows improved performance in modelling SAGE data. The Poisson mixture model used in this work provides better estimates of statistical significance, is highly effective when using multiple sample types, and is a flexible framework for more complex meta-analyses.
Prospective Student Info Sessions
Faculty of Medicine Information SessionDate: Tuesday, 08 December 2020
Time: 11:00 to 12:00
UBC’s Faculty of Medicine is a global leader in both the science and the practice of medicine, and is home to more than 1,700 graduate students across over 20 graduate programs. In this session hosted by Dr Michael Hunt, Associate Dean, Graduate and Postdoctoral Education, we’ll provide an overview of the diverse array of graduate programs available, including cutting-edge research experiences in the biosciences, globally recognized population health education, quality health professional training, as well as certificate and online training options. Dr Hunt will also be joined by program advisors from across the faculty to take an inside look at the application process and provide some application tips to help make your application as strong as possible.