An early change in cardiac metabolism is considered a major culprit for diabetic cardiomyopathy. The metabolic shift in the diabetic heart includes reduced glucose consumption, and a switch to utilize more fatty acids for energy, a destructive adaptation implicated in cell death. The Rodrigues Lab is interested in examining the mechanism of how fatty acids are provided to the heart and how an excess can lead to cardiac disease. Appreciating this mechanism should allow the identification of novel targets for therapeutic intervention to prevent heart failure during diabetes.
Our lab has a variety of exciting ongoing projects investigating cardiac metabolism and diabetes. Students will be responsible for the design and execution of research projects and will be expected to use animal modeling, cell culture (endothelial cells and cardiomyocyte isolation), and other molecular biology/biochemistry techniques. Applicants will be expected to apply for grants, write abstracts and manuscripts from the results obtained, and work well within a collaborative environment.
Applicants should have a M.Sc. in pharmacology, biochemistry, or a related field with relevant experience.
Please send a detailed CV, and a cover letter describing your research experience, research interests and future research goals to: