POST-DOCTORAL POSITION: Preclinical studies of SARS-CoV-2/COVID-19 candidate therapeutics using 2D- and 3D- cell culture and organoids


Dr. Jean is currently leading five major international research initiatives to discover novel antivirals for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Dr. Jean’s COVID-19 interdisciplinary team is one of Canada’s best-positioned consortia to rapidly identify lead drug candidates using state-of-the art molecular virology tools and organoid-based screening platforms. The main objective of Dr. Jean’s new cross-disciplinary team-based research is to contribute to the global response to the COVID-19 pandemic by identifying drug candidates for SARS-CoV-2 infection either tested alone or in combination using human organoid-based screening platforms with the goal of identifying synergistic drug combinations.


The successful applicant will perform preclinical studies of novel SARS-CoV-2/COVID-19 candidate therapeutics using 2D- and 3D- cell culture and human organoids. Research findings obtained by the postdoctoral fellow will be critical for clinical and public health responses and development of a therapeutic armamentarium for COVID-19 and other emerging pathogenic coronaviruses. The successful applicant will join a cross-disciplinary research environment at The UBC Life Sciences Institute with state-of-the-art CFI funded infrastructure, including one of the largest university-based containment level 3 (CL3) facilities in the world and founded by Dr. Jean. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources and state-of-the-art equipment at the UBC Life Sciences Institute, the candidate will be able to build on the existing COVID-19 funded research of Jean lab to quickly start up the preclinical studies on newly discovered SARS-CoV-2/COVID-19 candidate therapeutics by Dr. Jean’s team. The position will provide a unique opportunity for mentoring trainees, supervising technicians and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful biomedical research career in academia or industry. This full-time grant funded position with the University of British Columbia, Life Sciences Institute, allows the candidate to flourish under the guidance of an experienced mentor.


The Postdoctoral Fellow will play a leadership role in the Jean lab, and will be reporting directly to Dr. François Jean who is the primary investigator of the laboratory.


  • Planning, designing, and performing experiments using virally infected 2D- and 3D- cell culture and organoids
  • Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages
  • Updating Dr. Jean and the group on the status of projects during lab meetings, in email correspondence and virtual meetings
  • Managing projects with key academic and industry partners


PhD in a related applied biomedical discipline (e.g., cell biology, virology, molecular biology)

Demonstrated experience conducting research in the following areas:

  • Minimum of five years related laboratory experience
  • Demonstrated solid expertise with cell culture including 2D- and 3D- cell culture and organoids
  • Experience with virological assays including viral infection of cultured cells will be considered an asset
  • Demonstrated expertise with fluorescence-based imaging including confocal microscopy will be considered an asset
  • Strong problem-solving skills
  • Statistical data analysis and database management skills
  • Excellent written/verbal communication skills and organizational skills
  • Demonstrated ability to work in a team environment
  • Demonstrated research productivity (peer-reviewed publications and conference presentations)
  • Ability to work autonomously and take a lead role on projects under the supervision of the principal investigator


  • Experience with 2D and 3D- culture and organoids
  • Advanced bio-imaging and statistical methods and ability to work with a variety of analytic software
  • Experience with human pathogenic viruses and cell-based system of viral infection
  • Experience with student mentoring and supervision
  • Openness to learn new methods and techniques with Risk Group 3 viruses in an CL3 laboratory


  • Works independently under direction of Principal Investigator, Dr. François Jean
  • Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally


  • Assists and oversees research assistants and students as required
  • Assists and provides guidelines to other research members, as required


  • The start date is immediate but flexible; funding has already been received
  • The position is full time for one year and is renewable. The funding package consists of a stipend (consistent with CIHR funding levels) plus conference / training funding


Exceptional candidates should submit the following:

  • A complete curriculum vitae, including summary of GPA’s, a full publication list (including hyperlinks where possible) and email contact details for three referees
  • A letter of motivation and statement of research accomplishments and future research goals
  • 2-3 research publications that best demonstrate your fit for the position
Reference Number

Please mention reference number GPS-54417 in all your correspondence about this Postdoctoral Fellow position.

This position will be supervised by
The position is affilated with / related to
Classified under
Medical virology
Health sciences
Medical biotechnology

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