POST-DOCTORAL POSITION: Preclinical studies of SARS-CoV-2/COVID-19 candidate therapeutics using 2D- and 3D- cell culture and organoids

PROJECT SUMMARY

Dr. Jean is currently leading five major international research initiatives to discover novel antivirals for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Dr. Jean’s COVID-19 interdisciplinary team is one of Canada’s best-positioned consortia to rapidly identify lead drug candidates using state-of-the art molecular virology tools and organoid-based screening platforms. The main objective of Dr. Jean’s new cross-disciplinary team-based research is to contribute to the global response to the COVID-19 pandemic by identifying drug candidates for SARS-CoV-2 infection either tested alone or in combination using human organoid-based screening platforms with the goal of identifying synergistic drug combinations.

POSITION SUMMARY

The successful applicant will perform preclinical studies of novel SARS-CoV-2/COVID-19 candidate therapeutics using 2D- and 3D- cell culture and human organoids. Research findings obtained by the postdoctoral fellow will be critical for clinical and public health responses and development of a therapeutic armamentarium for COVID-19 and other emerging pathogenic coronaviruses. The successful applicant will join a cross-disciplinary research environment at The UBC Life Sciences Institute with state-of-the-art CFI funded infrastructure, including one of the largest university-based containment level 3 (CL3) facilities in the world and founded by Dr. Jean. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources and state-of-the-art equipment at the UBC Life Sciences Institute, the candidate will be able to build on the existing COVID-19 funded research of Jean lab to quickly start up the preclinical studies on newly discovered SARS-CoV-2/COVID-19 candidate therapeutics by Dr. Jean’s team. The position will provide a unique opportunity for mentoring trainees, supervising technicians and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful biomedical research career in academia or industry. This full-time grant funded position with the University of British Columbia, Life Sciences Institute, allows the candidate to flourish under the guidance of an experienced mentor.

ORGANIZATIONAL STATUS

The Postdoctoral Fellow will play a leadership role in the Jean lab, and will be reporting directly to Dr. François Jean who is the primary investigator of the laboratory.

WORK PERFORMED

  • Planning, designing, and performing experiments using virally infected 2D- and 3D- cell culture and organoids
  • Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages
  • Updating Dr. Jean and the group on the status of projects during lab meetings, in email correspondence and virtual meetings
  • Managing projects with key academic and industry partners

REQUIRED QUALIFICATIONS

PhD in a related applied biomedical discipline (e.g., cell biology, virology, molecular biology)

Demonstrated experience conducting research in the following areas:

  • Minimum of five years related laboratory experience
  • Demonstrated solid expertise with cell culture including 2D- and 3D- cell culture and organoids
  • Experience with virological assays including viral infection of cultured cells will be considered an asset
  • Demonstrated expertise with fluorescence-based imaging including confocal microscopy will be considered an asset
  • Strong problem-solving skills
  • Statistical data analysis and database management skills
  • Excellent written/verbal communication skills and organizational skills
  • Demonstrated ability to work in a team environment
  • Demonstrated research productivity (peer-reviewed publications and conference presentations)
  • Ability to work autonomously and take a lead role on projects under the supervision of the principal investigator

PREFERENCE WILL BE GIVEN TO CANDIDATES WITH:

  • Experience with 2D and 3D- culture and organoids
  • Advanced bio-imaging and statistical methods and ability to work with a variety of analytic software
  • Experience with human pathogenic viruses and cell-based system of viral infection
  • Experience with student mentoring and supervision
  • Openness to learn new methods and techniques with Risk Group 3 viruses in an CL3 laboratory

SUPERVISION RECEIVED

  • Works independently under direction of Principal Investigator, Dr. François Jean
  • Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

SUPERVISION GIVEN

  • Assists and oversees research assistants and students as required
  • Assists and provides guidelines to other research members, as required

START DATE, DURATION, STIPEND, AND LOCATION

  • The start date is immediate but flexible; funding has already been received
  • The position is full time for one year and is renewable. The funding package consists of a stipend (consistent with CIHR funding levels) plus conference / training funding

HOW TO APPLY?

Exceptional candidates should submit the following:

  • A complete curriculum vitae, including summary of GPA’s, a full publication list (including hyperlinks where possible) and email contact details for three referees
  • A letter of motivation and statement of research accomplishments and future research goals
  • 2-3 research publications that best demonstrate your fit for the position
 
Reference Number

Please mention reference number GPS-54417 in all your correspondence about this Postdoctoral Fellow position.

This position will be supervised by
The position is affilated with / related to
Classified under
Medical virology
Health sciences
Medical biotechnology
 
 
 

Learn about our faculties, research, and more than 300 programs in our 2021 Graduate Viewbook!